High frequency ultrasound to assess skin thickness in healthy adults

Mulder, T.J.S. Van; Koeijer, M. de; Theeten, Heidi; Willems, Dick L.; Damme, Pierre Van; Demolder, M.; Meyer, Guido R.Y. De; Beyers, Koen; Vankerckhoven, Vanessa

doi:10.1016/j.vaccine.2016.07.039

Cited by 68 publications

(78 citation statements)

References 18 publications

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“…1 Furthermore, the observed associations varied according to body site and were stronger for the limbs than for the trunk, which is compatible with the notion that the increased NMSC risk associated with HCTZ use is mediated through a photosensitizing effect. The difference in associations according to sex may be related to differences in skin thickness (ie, women have a thinner layer of both epidermis and dermis than men) 28 and sun habits (ie, women are more frequent tanners than men), 29 which may confer a difference in susceptibility to the effects of photosensitizing exposure.…”

Section: Discussionmentioning

confidence: 99%

Hydrochlorothiazide use and risk of nonmelanoma skin cancer: A nationwide case-control study from Denmark

Pedersen

Garcı́a-Dorado

Schmidt

et al. 2018

Journal of the American Academy of Dermatology

239

224

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Section: Discussionmentioning

confidence: 99%

Hydrochlorothiazide use and risk of nonmelanoma skin cancer: A nationwide case-control study from Denmark

Pedersen

Garcı́a-Dorado

Schmidt

et al. 2018

Journal of the American Academy of Dermatology

239

224

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“…The air‐pulse‐induced displacement is a broadband signal (∼0‐800 Hz) . With a wave speed of ∼2 m/s and a central frequency of ∼400 Hz, the corresponding wavelength was ∼5 mm, which is long enough to reach the subcutaneous fat in the hypodermis region . Hence, a thicker dermis resulted in a faster elastic wave, because of the absence of subcutaneous fat within the probing range of the elastic wave.…”

Section: Discussionmentioning

confidence: 99%

Translational optical coherence elastography for assessment of systemic sclerosis

Liu

Assassi

Theodore

et al. 2019

Journal of Biophotonics

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Systemic sclerosis (SSc‐scleroderma) is an autoimmune disorder with high mortality rate that results in excessive accumulation of collagen in the skin and internal organs. Currently, the modified Rodnan Skin Score (mRSS) is the gold standard for evaluating the dermal thickening due to SSc. However, mRSS has noticeable inter‐ and intra‐observer variabilities as quantified by the interclass correlation coefficient (ICC: 0.6‐0.75). In this work, optical coherence elastography (OCE) combined with structural optical coherence tomography (OCT) image analysis was used to assess skin thickness in 12 SSc patients and healthy volunteers. Inter‐ (ICC: 0.62‐0.99) and intra‐observer (ICC > 0.90) assessment of OCT/OCE showed excellent reliability. Clinical assessments, including histologically assessed dermal thickness (DT), mRSS, and site‐specific mRSS (SMRSS) were also performed for further validation. The OCE and OCT results from the forearm demonstrated the highest correlation (OCE: 0.78, OCT: 0.65) with SMRSS. Importantly, OCE and OCT had stronger correlations with the histological DT (OCT: r = .78 and OCE: r = .74) than SMRSS (r = .57), indicating the OCT/OCE could outperform semi‐quantitative clinical assessments such as SMRSS. Overall, these results demonstrate that OCT/OCE could be useful for rapid, noninvasive and objective assessments of SSc onset and monitoring skin disease progression and treatment response.

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“…Of all imaging tools, RCM is superior for noninvasive skin thickness measurements. Possible alternatives are high-frequency ultrasound, near-infrared spectroscopy, optical coherence tomography, or Raman spectroscopy; however, these devices have lower resolution and are also expensive [17,[37][38][39]. Moreover, they may not all be suitable for facial imaging due to their size (e.g., Raman spectroscopy).…”

Section: Discussionmentioning

confidence: 99%

Noninvasive Skin Barrier Assessment: Multiparametric Approach and Pilot Study

et al. 2019

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The epidermal barrier function is disrupted in various inflammatory skin diseases. Accurate methods to measure skin barrier function are needed to assess the effect of therapeutic agents. Therefore, we developed a noninvasive multiparametric approach to measure four different parameters regarding the skin barrier. In the current pilot study, we evaluate this method in 14 healthy volunteers. We assessed erythema, transepidermal water loss (TEWL), water content, and epidermal thickness at both cheeks before and 30 min after application of Lanette and Vaseline-Lanette cream. For this, we used spectrophotometry, the Aquaflux device, the Epsilon device, and reflection confocal microscopy, respectively. Stratum corneum (SC) thickness was significantly increased after application of both creams (p < 0.05), and this increase was larger after Lanette cream compared to after Vaseline-Lanette cream (p = 0.035). Erythema, TEWL, and water content did not significantly change after cream application. Our multiparametric approach is promising and offers a feasible and practical way to quickly obtain multifaceted information about skin barrier function. Further exploration of this approach after prolonged use of cream and in conditions of disrupted skin barrier are recommended areas for future research.

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High frequency ultrasound to assess skin thickness in healthy adults

Cited by 68 publications

References 18 publications

Hydrochlorothiazide use and risk of nonmelanoma skin cancer: A nationwide case-control study from Denmark

Hydrochlorothiazide use and risk of nonmelanoma skin cancer: A nationwide case-control study from Denmark

Translational optical coherence elastography for assessment of systemic sclerosis

Noninvasive Skin Barrier Assessment: Multiparametric Approach and Pilot Study

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