High fructose-containing drinking water-induced steatohepatitis in rats is prevented by the nicotinamide-mediated modulation of redox homeostasis and NADPH-producing enzymes

Loza-Medrano, Sarahi; Baiza-Gutman, Luís Arturo; Manuel‐Apolinar, Leticia; García‐Macedo, Rebeca; Damasio-Santana, Leticia; Martínez-Mar, O. A.; Sánchez-Becerra, Martha Catalina; Cruz-López, Miguel; Hernández, Miguel; Díaz‐Flores, Margarita

doi:10.1007/s11033-019-05136-4

Cited by 27 publications

(23 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, our results revealed that a high fat-fructose diet increased food intake, with marked weight gain due to the caloric contribution provided by fat and carbohydrates in obese group. We also found metabolic alterations, such as increases in glucose, triglycerides, cholesterol and the HOMA-IR index, similar to other studies that have used hypercaloric diets [14,15]. Hence, our results showed that with obesity triggered dysmetabolism, hyperglycemia and hypertriglyceridemia, as well as an increase of the levels of in ammatory cytokines (TNF-a, IL-6), are present.…”

Section: Discussionsupporting

confidence: 91%

“…However, to facilitate other tissue and organ analyses, the feeding continued in both groups until the animals reached 12 months of age, at this time point, the rats were sacri ced via deep anesthesia and the single dose administration of pentobarbital (25 mg/kg, i.p.) [14] (NOM-062-ZOO-1999, revised 2001).…”

Section: Animals and Model Of Obesitymentioning

confidence: 99%

“…At this time point, the rats were sacri ced via deep anesthesia and the administration of pentobarbital (25 mg/kg, i.p.) [14] (NOM-062-ZOO-1999, revised 2001). Blood samples were collected by cardiac puncture, and these samples and other tissues were used for cytokines and other analysis.…”

Section: Declarations Ethics Approval and Consent To Participatementioning

confidence: 99%

See 2 more Smart Citations

Echography analysis of musculoskeletal, heart and liver alterations associated with endothelial dysfunction in obese rats

Coria

Estrada-Cruz

Ordoñez

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Background: Modern imaging plays a central role in the care of obese patients, and there is an integral focus on its use and accessibility in individuals who have alterations of various in various organs. The objective in this study was to perform an echographic analysis of musculoskeletal system disorders, endothelial dysfunction and the left ventricle (LV) in obese rats. Methods: Sprague Dawley rats (250±5g) were obtained and divided into two groups: the control (C) group was fed with a standard diet, and the obese (Ob) group was fed hyper caloric diet with a high fructose-fat content for 4 months. Body weight, cholesterol, triglycerides, glucose, inflammatory cytokines and adhesion molecules (ICAM-1, VCAM-1) were measured. Additionally, two-dimensional echocardiography, abdominal ultrasound and musculoskeletal system studies were performed in the lower extremities. Results: The body weight in the Ob group was increased compared to that in the control group, (p<0.001); in addition, increased glucose, cholesterol and triglyceride concentrations (p<0.05) as well as increased levels of the adhesion molecules ICAM-1 and, VCAM-1 (p<0.01) were found in the Ob group vs the C group. On ultrasound, 75% of the Ob group presented fatty liver and distal joint abnormalities. Conclusion: Obese rats exhibit endothelial dysfunction and musculoskeletal changes, also, fatty liver and articular cysts in the posterior region of the distal lower- extremity joints.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Animals and Model Of Obesitymentioning

confidence: 99%

See 1 more Smart Citation

Echography analysis of musculoskeletal, heart and liver alterations associated with endothelial dysfunction in obese rats

Coria

Estrada-Cruz

Ordoñez

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…For collection of blood samples by cardiac puncture, also analysis of cytokines in tissue, rats were sacrificed with deeply anesthetized and administered pentobarbital (25 mg/kg, i.p.) [10].…”

Section: Metabolic Parameters and Body Weightmentioning

confidence: 99%

Echographic analysis of the alterations musculoskeletal associated with endothelial dysfunction and obesity

Coria

Estrada-Cruz

Ordoñez

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Background: Modern imaging plays a central role in the care of obese patients, with an integral focus on its use and accessibility in individuals with this condition with alterations of various organs.Objective. To perform an echographical analysis of musculoskeletal system disorders, endothelial dysfunction and the left ventricle in obese rats.Methods. Sprague Dawley rats (250±5 g) were used and divided into two groups: control group (C) fed a standard diet and the obese group (Ob), fed with a hyper caloric diet of high fructose-fat for 4 mounts. Body weight, cholesterol, triglycerides, glucose, inflammatory cytokines and adhesion molecules (ICAM-1, VCAM-1) were measured. Additionally, two-dimensional echocardiography and abdominal ultrasound and musculoskeletal system studies in the lower extremities were performed.Results . Body weight in the Ob group was increased compared to the control group, (p <0.001); in addition, increased glucose, cholesterol and triglycerides of were found in the Ob group vs the C group, (p <0.05), and as well as increased adhesion molecules ICAM-1 and, VCAM-1 (p <0.01). On ultrasound, 75% of the Ob group presented showed 75% fatty liver and distal joint abnormalities.Conclusion . Endothelial dysfunction and changes at the level of the musculoskeletal system with the presence of joint cysts in the posterior region of the distal joint of the lower extremities were observed in obese rodents.

show abstract

“…However, to facilitate other tissue and organ analyses, the feeding continued in both groups until the animals reached 12 months of age, at this time point, the rats were sacrificed via deep anesthesia and the single dose administration of pentobarbital (25 mg/ kg, i.p.) [13] (NOM-062-ZOO-1999, revised 2001).…”

Section: Animals and Model Of Obesitymentioning

confidence: 99%

Echography analysis of musculoskeletal, heart and liver alterations associated with endothelial dysfunction in obese rats

et al. 2020

Self Cite

View full text Add to dashboard Cite

Background: Modern imaging plays a central role in the care of obese patients, and there is an integral focus on its use and accessibility in individuals who have alterations of various in various organs. The objective in this study was to perform an echographic analysis of musculoskeletal system disorders, endothelial dysfunction and the left ventricle (LV) in obese rats. Methods: Sprague Dawley rats (250 ± 5 g) were obtained and divided into two groups: the control (C) group was fed with a standard diet, and the obese (Ob) group was fed hyper caloric diet with a high fructose-fat content for 4 months. Body weight, cholesterol, triglycerides, glucose, inflammatory cytokines and adhesion molecules (ICAM-1, VCAM-1) were measured. Additionally, two-dimensional echocardiography, abdominal ultrasound and musculoskeletal system studies were performed in the lower extremities. Results: The body weight in the Ob group was increased compared to that in the control group, (p < 0.001); in addition, increased glucose, cholesterol and triglyceride concentrations (p < 0.05) as well as increased levels of the adhesion molecules ICAM-1 and, VCAM-1 (p < 0.01) were found in the Ob group vs the C group. On ultrasound, 75% of the Ob group presented fatty liver and distal joint abnormalities. Conclusion: Obese rats exhibit endothelial dysfunction and musculoskeletal changes, also, fatty liver and articular cysts in the posterior region of the distal lower-extremity joints.

show abstract

High fructose-containing drinking water-induced steatohepatitis in rats is prevented by the nicotinamide-mediated modulation of redox homeostasis and NADPH-producing enzymes

Cited by 27 publications

References 66 publications

Echography analysis of musculoskeletal, heart and liver alterations associated with endothelial dysfunction in obese rats

Echography analysis of musculoskeletal, heart and liver alterations associated with endothelial dysfunction in obese rats

Echographic analysis of the alterations musculoskeletal associated with endothelial dysfunction and obesity

Echography analysis of musculoskeletal, heart and liver alterations associated with endothelial dysfunction in obese rats

Contact Info

Product

Resources

About