High-fructose in drinking water initiates activation of inflammatory cytokines and testicular degeneration in rat

Yıldırım, Onur; Sumlu, Esra; Aslan, Esra; Koca, Halit Buğra; Pektaş, Mehmet Bilgehan; Sadı, Gökhan; Akar, Fatma

doi:10.1080/15376516.2018.1543745

Cited by 29 publications

(26 citation statements)

References 35 publications

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“…Therefore, we evaluated the effects of the supplementation of two commonly used probiotic microorganisms, L. helveticus and L. plantarum, on metabolic, plasma and renal antioxidant/oxidant markers. The findings presented herein demonstrated hyperinsulinemia and hypertriglyceridemia with high-fructose intake, which is in accordance with our previous studies [3,4,6,9]. There were no significant alteration in the body weights and the ratio of renal weights to body weights in rats fed with high-fructose diet.…”

Section: Discussionsupporting

confidence: 93%

“…Excess sugar intake, especially of fructose, has been shown to induce metabolic syndrome and kidney diseases via several molecular mechanisms, including activation of inflammatory processes and generation of oxidative stress [1,2]. We previously described the upregulation of the inflammatory pathway and induction of the superoxide-producing system in various tissues with high dietary fructose intake [3][4][5][6][7][8][9]. Development of a proinflammatory condition, as manifested by nuclear factor-kappa B (NF-κB) activation, high expression of tumor necrosis factor-α (TNF-α), inducible nitric oxide synthase (iNOS) and interleukin-6 (IL-6), was demonstrated in the renal tissue of high-fructose-fed rats [10].…”

Section: Introductionmentioning

confidence: 99%

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Lactobacillus helveticus and Lactobacillus plantarum modulate renal antioxidant status in a rat model of fructose-induced metabolic syndrome

Korkmaz

Sadı

Kocabaş

et al. 2019

Arch biol sci (Beogr)

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High dietary fructose intake causes a metabolic disorder and augments the risk of chronic kidney disease most likely due to oxidative stress. Probiotics could have antioxidant, antiinflammatory and immunoregulatory properties. The present study examined the influence of Lactobacillus helveticus and Lactobacillus plantarum supplementation on dietary fructose-induced metabolic changes and renal antioxidant/oxidant status of rats. Male Wistar rats were divided into four groups as follows: control; fructose; fructose plus L. helveticus; fructose plus L. plantarum. Fructose was given to the rats as a 20% solution in drinking water for 15 weeks. The probiotic supplementation was applied by gastric gavage once a day for six weeks. Several metabolic parameters in the plasma, gene and protein expressions of the main antioxidant enzymes in renal tissues of rats were measured. Dietary fructose-induced elevations in plasma insulin, triglyceride, VLDL, creatinine as well as renal urea levels were alleviated after treatment with L. helveticus and L. plantarum. Moreover, L. helveticus and L. plantarum supplementation recovered the changes in renal protein expression level of SOD1, SOD2 and CAT. In conclusion, supplementation with L. helveticus and L. plantarum has an improving effect on specific metabolic parameters and renal antioxidative enzymes in a fructose-induced metabolic disorder.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Lactobacillus helveticus and Lactobacillus plantarum modulate renal antioxidant status in a rat model of fructose-induced metabolic syndrome

Korkmaz

Sadı

Kocabaş

et al. 2019

Arch biol sci (Beogr)

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“…When we investigated links with habitual diet, we found that high vegetable intake, particularly green leafy and cruciferous vegetables, correlated with lower levels of white blood cell counts. No such relationship was seen with fruit intake, which may be a consequence of the relatively high sugar content of fruit compared to vegetables [42] and that a high sugar diet has been shown to be pro-inflammatory [42,43]. On the other hand, it may be due to the presence of compounds common in vegetables but not in fruits.…”

Section: Discussionmentioning

confidence: 92%

High intake of vegetables is linked to lower white blood cell profile and the effect is mediated by the gut microbiome

Menni

Louca

Berry

et al. 2021

BMC Med

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Background Chronic inflammation, which can be modulated by diet, is linked to high white blood cell counts and correlates with higher cardiometabolic risk and risk of more severe infections, as in the case of COVID-19. Methods Here, we assessed the association between white blood cell profile (lymphocytes, basophils, eosinophils, neutrophils, monocytes and total white blood cells) as markers of chronic inflammation, habitual diet and gut microbiome composition (determined by sequencing of the 16S RNA) in 986 healthy individuals from the PREDICT-1 nutritional intervention study. We then investigated whether the gut microbiome mediates part of the benefits of vegetable intake on lymphocyte counts. Results Higher levels of white blood cells, lymphocytes and basophils were all significantly correlated with lower habitual intake of vegetables, with vegetable intake explaining between 3.59 and 6.58% of variation in white blood cells after adjusting for covariates and multiple testing using false discovery rate (q < 0.1). No such association was seen with fruit intake. A mediation analysis found that 20.00% of the effect of vegetable intake on lymphocyte counts was mediated by one bacterial genus, Collinsella, known to increase with the intake of processed foods and previously associated with fatty liver disease. We further correlated white blood cells to other inflammatory markers including IL6 and GlycA, fasting and post-prandial glucose levels and found a significant relationship between inflammation and diet. Conclusion A habitual diet high in vegetables, but not fruits, is linked to a lower inflammatory profile for white blood cells, and a fifth of the effect is mediated by the genus Collinsella. Trial registration The ClinicalTrials.gov registration identifier is NCT03479866.

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“…Insulin resistance, together with inflammatory status, might occur due to excess nutritional fructose and affect the intestinal microbiota [1,2]. In our previous studies, we showed that high-fructose intake changed the expression levels of insulin signaling effectors, such as insulin receptor (IR), insulin receptor substrates (IRS-1 and IRS-2), protein kinase B (AKT), or endothelial nitric oxide synthase (eNOS), as well as activated inflammatory markers in blood vessel, adipose tissue, liver, and testis of rats [3,4,5,6,7,8]. In studies with kidney tissue of high-fructose-fed rats, reduced expression or phosphorylation of IR, IRS-1, and AKT, as well as overproduction of cytokines, such as interleukin (IL)-1β, IL-6, and tumor necrosis factor α (TNF-α), indicated that there is a connection between inflammation and impaired insulin signaling [9,10].…”

Section: Introductionmentioning

confidence: 99%

Effects of Lactobacillus Plantarum and Lactobacillus Helveticus on Renal Insulin Signaling, Inflammatory Markers, and Glucose Transporters in High-Fructose-Fed Rats

et al. 2019

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Background and Objectives: The excess consumption of fructose in the diet may cause metabolic syndrome, which is associated with an increased risk of kidney disease. There is limited data on probiotic treatment in high-fructose-induced metabolic syndrome. The present study aims to investigate whether the supplementation of Lactobacillus plantarum (L. plantarum) and Lactobacillus helveticus (L. helveticus) could provide an improving effect on the renal insulin signaling effectors, inflammatory parameters, and glucose transporters in fructose-fed rats. Materials and Methods: The model of metabolic syndrome in male Wistar rats was produced by fructose, which was given as 20% solution in drinking water for 15 weeks. L. plantarum and L. helveticus supplementations were given by gastric gavage from 10 to 15 weeks of age. Results: High-fructose consumption in rats reduced renal protein expressions of insulin receptor substrate (IRS)-1, protein kinase B (AKT), and endothelial nitric oxide synthase (eNOS), which were improved by L. plantarum and partially by L. helveticus supplementations. Dietary fructose-induced elevations in renal tissue levels of tumor necrosis factor α (TNF-α), interleukin (IL)-1β, IL-6, and IL-10, as well as expression of IL-6 mRNA, were attenuated, especially in L. plantarum treated rats. The increased renal expression of sodium-glucose cotransporter-2 (SGLT2), but not that of glucose transporter type-5 (GLUT5), was suppressed by the treatment with L. plantarum. Conclusion: Suppression in insulin signaling pathway together with the induction of inflammatory markers and upregulation of SGLT2 in fructose-fed rats were improved by L. plantarum supplementation. These findings may offer a new approach to the management of renal dysregulation induced by dietary high-fructose.

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High-fructose in drinking water initiates activation of inflammatory cytokines and testicular degeneration in rat

Cited by 29 publications

References 35 publications

Lactobacillus helveticus and Lactobacillus plantarum modulate renal antioxidant status in a rat model of fructose-induced metabolic syndrome

Lactobacillus helveticus and Lactobacillus plantarum modulate renal antioxidant status in a rat model of fructose-induced metabolic syndrome

High intake of vegetables is linked to lower white blood cell profile and the effect is mediated by the gut microbiome

Effects of Lactobacillus Plantarum and Lactobacillus Helveticus on Renal Insulin Signaling, Inflammatory Markers, and Glucose Transporters in High-Fructose-Fed Rats

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