High Fructose Intake and Adipogenesis

Hernández-Díazcouder, Adrián; Romero‐Nava, Rodrigo; Carbó, Roxana; Sánchez‐Lozada, Laura G.; Sánchez‐Muñoz, Fausto

doi:10.3390/ijms20112787

Cited by 54 publications

(50 citation statements)

References 143 publications

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“…These results are in line with those reported in the literature showing that the beneficial effects of carrot on adipose tissue can be attributed to their carotenoid and polyphenol content [29,30]. Moreover, among other components present in carrots, sugar may interfere with several adipocyte functions as both fructose and sucrose are recognized to induce adipogenesis [31,32]. Sugar content of the carrot might participate to the reduced fat accumulation observed in the present study.…”

Section: Discussionsupporting

confidence: 93%

Carrot Genotypes Contrasted by Root Color and Grown under Different Conditions Displayed Differential Pharmacological Profiles in Vascular and Metabolic Cells

et al. 2020

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Carrots’ genotype and growing conditions influence their potential properties to fight against cardiovascular and metabolic diseases. The present study evaluated the influence of carrot genotypes contrasted by root color (Bolero, Presto, Karotan, Deep Purple, Kintoki and Blanche des Vosges) growing under standard, water-restricted, biotic stress (Alternaria dauci inoculation), and combined stress conditions (water restriction and A. dauci inoculation). The effect of carrots’ polyphenol and carotenoid content was assessed on endothelial and smooth muscle cells, hepatocytes, adipocytes and macrophages functions (oxidative stress, apoptosis, proliferation, lipid accumulation and inflammation). Independently of varieties or growing conditions, all carrot extracts affected vascular cells’ oxidative stress and apoptosis, and metabolic cells’ oxidative stress and lipid accumulation. Three clusters were revealed and displayed beneficial properties mostly for adipocytes function, smooth muscle cells and hepatocytes, and endothelial cells and hepatocytes, respectively. Karotan and Presto varieties exhibited endothelial tropism while Blanche des Vosges targeted adipocytes. Carrots under biotic stress are more efficient in inducing beneficial effects, with the Bolero variety being the most effective. However, extracts from carrots which grew under combined stress conditions had limited beneficial effects. This report underscores the use of certain carrot extracts as potential effective nutraceutical supplements for metabolic diseases.

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Section: Discussionsupporting

confidence: 93%

Carrot Genotypes Contrasted by Root Color and Grown under Different Conditions Displayed Differential Pharmacological Profiles in Vascular and Metabolic Cells

et al. 2020

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“…34 In addition, fructose overload increases GLUT5 expression in WAT, 35 concurring for WAT hyperplasia as well as adipocyte hypertrophy. 36 Noteworthy, most HSD-induced metabolic disturbances are reversible by the withdrawal of excess dietary sucrose. 37 On the contrary, we cannot rule out the possible impact of the lower protein content in our HSD on body weight gain.…”

Section: Discussionmentioning

confidence: 99%

Post-weaning exposure to high-sucrose diet induces early non-alcoholic fatty liver disease onset and progression in male mice: role of dysfunctional white adipose tissue

França

Santos

Barroso

et al. 2020

J Dev Orig Health Dis

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Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome, ranging from simple steatosis to non-alcoholic steatohepatitis (NASH) particularly among chronic consumers of added sugar-rich diets. However, the impact of early consumption of such diets on NAFLD onset and progression is unclear. Thus, this study sought to characterise metabolic factors involved in NAFLD progression in young mice fed with a high-sucrose diet (HSD). Male Swiss mice were fed HSD or regular chow (CTR) from weaning for up to 60 or 90 days. Obesity development, glucose homeostasis and serum biochemical parameters were determined at each time-point. At day 90, mice were euthanised and white adipose tissue (WAT) collected for lipolytic function assessment and liver for histology, gene expression and cytokines quantification. At day 60, HSD mice presented increased body mass, hypertriglyceridemia, peripheral insulin resistance (IR) and simple steatosis. Upon 90 days on diet, WAT from HSD mice displayed impaired insulin sensitivity, which coincided with increased fasting levels of glucose and free fatty acids (FFA), as well as NAFLD progression to NASH. Transcriptional levels of lipogenic genes, particularly stearoyl-CoA desaturase-1, were consistently increased, leading to hepatic leukocyte infiltration and pro-inflammatory cytokines spillover. Therefore, our dataset supports IR triggering in the WAT as a major factor for dysfunctional release of FFA towards portal circulation and consequent upregulation of lipogenic genes and hepatic inflammatory onset, which decisively concurred for NAFLD-to-NASH progression in young HSD-fed mice. Notwithstanding, this study forewarns against the early introduction of dietary sugars in infant diet, particularly following breastfeeding cessation.

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“…Overexpressed miR-377 triggers activation of O2(-) / p38MAPK / TXNIP / NLR family pyrin domain containing 3 (NLRP3) inflammasome pathway inducing OxS and podocyte injury [301]. Interestingly, Hernández-Díazcouder and collaborators reviewed some of the miRNAs that can be associated with the induction of adipogenesis by high-fructose diet (miR-206, miR-122, miR-33, miR-378a, miR-21, and miR-223) [302]. It has been indicated that DICER and miRNAs can modulate the inflammatory response and lipid metabolism in macrophages to suppress atherosclerosis.…”

Section: Microrna In Mets-a Link With Chronic Inflammation Related Tomentioning

confidence: 99%

The Role of microRNAs in Metabolic Syndrome-Related Oxidative Stress

Włodarski

Strycharz

Wróblewski

et al. 2020

IJMS

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Oxidative stress (OxS) is the cause and the consequence of metabolic syndrome (MetS), the incidence and economic burden of which is increasing each year. OxS triggers the dysregulation of signaling pathways associated with metabolism and epigenetics, including microRNAs, which are biomarkers of metabolic disorders. In this review, we aimed to summarize the current knowledge regarding the interplay between microRNAs and OxS in MetS and its components. We searched PubMed and Google Scholar to summarize the most relevant studies. Collected data suggested that different sources of OxS (e.g., hyperglycemia, insulin resistance (IR), hyperlipidemia, obesity, proinflammatory cytokines) change the expression of numerous microRNAs in organs involved in the regulation of glucose and lipid metabolism and endothelium. Dysregulated microRNAs either directly or indirectly affect the expression and/or activity of molecules of antioxidative signaling pathways (SIRT1, FOXOs, Keap1/Nrf2) along with effector enzymes (e.g., GPx-1, SOD1/2, HO-1), ROS producers (e.g., NOX4/5), as well as genes of numerous signaling pathways connected with inflammation, insulin sensitivity, and lipid metabolism, thus promoting the progression of metabolic imbalance. MicroRNAs appear to be important epigenetic modifiers in managing the delicate redox balance, mediating either pro- or antioxidant biological impacts. Summarizing, microRNAs may be promising therapeutic targets in ameliorating the repercussions of OxS in MetS.

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High Fructose Intake and Adipogenesis

Cited by 54 publications

References 143 publications

Carrot Genotypes Contrasted by Root Color and Grown under Different Conditions Displayed Differential Pharmacological Profiles in Vascular and Metabolic Cells

Carrot Genotypes Contrasted by Root Color and Grown under Different Conditions Displayed Differential Pharmacological Profiles in Vascular and Metabolic Cells

Post-weaning exposure to high-sucrose diet induces early non-alcoholic fatty liver disease onset and progression in male mice: role of dysfunctional white adipose tissue

The Role of microRNAs in Metabolic Syndrome-Related Oxidative Stress

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