A high-efficiency DC-DC converter employing a modified architecture called the hybrid switched inductor–capacitor series (MHSLCS) is proposed in this paper. The primary goal is to achieve a notably ultra-high voltage gain for renewable energy systems (RESs). Furthermore, the use of only one input capacitor in the MHSLCS eliminates pulsations in the input current at both low and high duty ratios. The proposed converter integrates the MHSLCS with a modified switched capacitor (MSC) that interleaves with the main MOSFET, effectively doubling the voltage transfer gain. Additionally, a modified hybrid switched inductor–capacitor parallel (MHSLCP) is incorporated in parallel with an interleaved auxiliary MOSFET. Both MOSFETs, combined with the MSC, contribute to achieving an ultra-high voltage gain. In addition, the inductors of the MHSLCP operate in a discontinuous conduction mode (DCM), which results in significant stress reductions in the power diodes and switches at high output voltages. The advantages of the proposed converter are multifaceted, demonstrating a high efficiency while minimizing the voltage in power device diodes and MOSFETs. The use of low inductance and capacitance values at high switching frequencies further enhances the performance. Wide-bandgap (WBG) power devices are employed to achieve the desired high voltage gain and efficiency. The proposed converter was designed with a PCB and underwent experimental testing to validate laboratory results. The proposed converter boosted the input voltage from 30 V to a variable output voltage between 325 V and 500 V, with a power output of 325 watts and an efficiency of 95.5%.