applications comprising optical communication, [1] environmental monitoring, [2] biological detection, [3] and image sensing. [4] In recent years, owing to their novel structures and properties, such as high carrier mobility, [5] strong light-matter interaction, [6] and dangling-bond free surface, [7] the rapid development of 2D materials has provided ideas for breaking through traditional photo detectors. In particular, 2D indium selenides (InSe and α-In 2 Se 3 ) are natural direct bandgap semiconductors in multilayer forms, [8] which allow an efficient generation of electron-hole pairs under photoexcitation. Therefore, 2D indium selenides could be the desirable candidates for photodetector applications. However, due to their atomically thin thickness, the inherent weak light absorption of single 2D indium selenides remains a major challenge for device development. In addition, most 2D photodetectors work in either photodiode or photogating mode, which inevitably requires a trade-off between responsivity and response speed. In the photodiode structure, devices exhibit a fast response speed with the aid of built-in fields, but suffer from a poor responsivity. [9] In photogating photodetectors, the trapped carriers could act as a local gate, which results in a high responsivity and photoconductive gain, accompanied by a slow response rate. [10] Ultrasensitive photodetectors with high responsivity, detectivity, and fast response rate have triggered urgent demand in extensive applications. In recent years, 2D indium chalcogenides have emerged as appealing photoactive materials due to their excellent electrical and optoelectronic properties. However, suffering from the weak optical absorption induced by atomically thin thickness as well as the short lifetime of photogenerated carriers, conventional 2D indium chalcogenides photodetectors commonly exhibit limited photodetection performance. Herein, a universal strategy integrating 2D indium chalcogenides and Si nanostripe array is demonstrated. The Si nanostripes afford Mie-type resonance, which facilitates light absorption. In addition, the introduction of photoconductive gain and strain engineering prolongs photogenerated carriers' lifetime and accelerates their transport. The coupling effect of these three mechanisms enables the device to exhibit high photodetection performance. The constructed α-In 2 Se 3 device manifests a high responsivity of 9.4 × 10 3 A W −1 , detectivity of 5.5 × 10 13 Jones while maintaining fast rise/decay time of 2.7/3.8 ms. In addition, this proposed strategy can also be employed to construct InSe device with comprehensively enhanced photodetection performance, which presents universality and wide applicability. These results demonstrate that advanced device design is an effective avenue to achieve future multifunctional optoelectronic devices with high sensitivity.