High‐glucose‐cultivated peripheral blood mononuclear cells impaired keratinocyte function via reduced <scp>IL</scp>‐22 expression: implications on impaired diabetic wound healing

Huang, Shu‐Mei; Wu, Ching‐Shuang; Chao, David; Wu, Chuan-Chun; Li, Ching-Chia; Chen, Gwo‐Shing; Lan, Cheng‐Che E.

doi:10.1111/exd.12733

Cited by 15 publications

(13 citation statements)

References 9 publications

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“…A study has shown that dysfunctional proinflammatory cellular function in hyperglycemic microenvironment hinders suboptimal interaction of reepithelialization process [24]. This shows that hyperglycemic metabolic impairment affects wound healing ability.…”

Section: Discussionmentioning

confidence: 99%

Effect of Thymoquinone on Wound Healing in Alloxan-Induced Diabetic Rats

Yusmin

Ahmad

2017

Asian J Pharm Clin Res

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Objective: Nigella sativa and its active constituent thymoquinone (TQ) have been extensively documented for its pharmacological values, but its application in wound healing in particular in a diabetic wound healing model is less documented. Methods:In our study, alloxan-induced diabetic rats were used as a chronic delayed wound model and topical administration of TQ 10% w/v were used to assess the role and function of TQ in wound healing through wound contraction and histological analysis.Results: Although statistically insignificant, we found out that TQ accelerated wound healing in post-wounding day 3 (inflammatory phase), whereas aggressively decelerating wound healing in post-wounding day 7 (proliferation phase). In addition, our histological analyses of wound granulation tissues at post-wounding day 14 substantiate our claim by showing that TQ treatment had delayed wound healing progression of the diabetic rats. Conclusions:Our study shows that TQ accelerates wound healing during the inflammatory phase; however, decelerate rapidly during the proliferation phase. We speculate the acceleration of wound healing during the inflammatory phase was due to its well-documented antioxidant, anti-inflammatory, and antimicrobial properties while its deceleration of wound healing during the proliferation phase was due to its well-documented antiangiogenic effect.

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Section: Discussionmentioning

confidence: 99%

Effect of Thymoquinone on Wound Healing in Alloxan-Induced Diabetic Rats

Yusmin

Ahmad

2017

Asian J Pharm Clin Res

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“…To further investigate the role of MMPs in keratinocyte migration, recent evidence has shown that cytokines produced by mononuclear cells such as IL-22 play an important role in the secretion of MMPs by keratinocytes [57]. However, they found that IL-22 expression is suppressed from blood mononuclear cells of diabetic rats, leading to decreased keratinocyte expression of MMP-3 and impaired keratinocyte migration [63].…”

Section: The Biology Of Impaired Wound Healing In Diabetesmentioning

confidence: 99%

The role of keratinocyte function on the defected diabetic wound healing

Mansoub

2022

Clinical Diabetology

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“…Introduction of mesenchymal stem cells to the wound bed can facilitate process of the skin defect healing [ 49 ]. Deregulation of the microenvironment during the wound healing results in delayed healing in venous ulcers or in diabetic foot syndrome [ 50 , 51 ]. Part of granulation tissue fibroblasts is transformed to the myofibroblasts due to activity of TGF-β1/3 and/or galectin-1 [ 52 , 53 ].…”

Section: Escs and Wound Healingmentioning

confidence: 99%

Cancer Microenvironment: What Can We Learn from the Stem Cell Niche

Lacina

Plzák

Kodet

et al. 2015

IJMS

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Epidermal stem cells (ESCs) are crucial for maintenance and self- renewal of skin epithelium and also for regular hair cycling. Their role in wound healing is also indispensable. ESCs reside in a defined outer root sheath portion of hair follicle—also known as the bulge region. ECS are also found between basal cells of the interfollicular epidermis or mucous membranes. The non-epithelial elements such as mesenchymal stem cell-like elements of dermis or surrounding adipose tissue can also contribute to this niche formation. Cancer stem cells (CSCs) participate in formation of common epithelial malignant diseases such as basal cell or squamous cell carcinoma. In this review article, we focus on the role of cancer microenvironment with emphasis on the effect of cancer-associated fibroblasts (CAFs). This model reflects various biological aspects of interaction between cancer cell and CAFs with multiple parallels to interaction of normal epidermal stem cells and their niche. The complexity of intercellular interactions within tumor stroma is depicted on example of malignant melanoma, where keratinocytes also contribute the microenvironmental landscape during early phase of tumor progression. Interactions seen in normal bulge region can therefore be an important source of information for proper understanding to melanoma. The therapeutic consequences of targeting of microenvironment in anticancer therapy and for improved wound healing are included to article.

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High‐glucose‐cultivated peripheral blood mononuclear cells impaired keratinocyte function via reduced IL‐22 expression: implications on impaired diabetic wound healing

Cited by 15 publications

References 9 publications

Effect of Thymoquinone on Wound Healing in Alloxan-Induced Diabetic Rats

Effect of Thymoquinone on Wound Healing in Alloxan-Induced Diabetic Rats

The role of keratinocyte function on the defected diabetic wound healing

Cancer Microenvironment: What Can We Learn from the Stem Cell Niche

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