High glucose exposure drives intestinal barrier dysfunction by altering its morphological, structural and functional properties

Dubois, Nolwenn; Muñoz-Garcia, Javier; Heymann, Dominique; Renodon-Cornière, Axelle

doi:10.1016/j.bcp.2023.115765

Cited by 6 publications

(2 citation statements)

References 66 publications

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“…Some diseases can also act as a disruptor factor of the intestinal barrier. For example, several studies show that hyperglycemia, a key feature of diabetes, induces intestinal barrier dysfunction ( Thaiss et al, 2018 ; Dubois et al, 2023 ). Prolonged exposure to glucose at high levels increases migration capacity of human colonic cell line Caco-2, resulting in layers appearing less organized than under physiological conditions.…”

Section: Intestinal Permeabilitymentioning

confidence: 99%

“…Prolonged exposure to glucose at high levels increases migration capacity of human colonic cell line Caco-2, resulting in layers appearing less organized than under physiological conditions. In particular, this is associated with decreased expression of tight junction (TJ) proteins, which contributes to the disruption of the structural network associated with them and an increase in the permeability of the intestinal barrier ( Dubois et al, 2023 ). In turn, this contributes to the penetration of luminal bacteria, and the development of dysbacteriosis resulting in inflammation.…”

Section: Intestinal Permeabilitymentioning

confidence: 99%

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Intestinal barrier permeability: the influence of gut microbiota, nutrition, and exercise

Dmytriv,

Storey,

Lushchak

2024

Front. Physiol.

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The intestinal wall is a selectively permeable barrier between the content of the intestinal lumen and the internal environment of the body. Disturbances of intestinal wall permeability can potentially lead to unwanted activation of the enteric immune system due to excessive contact with gut microbiota and its components, and the development of endotoxemia, when the level of bacterial lipopolysaccharides increases in the blood, causing chronic low-intensity inflammation. In this review, the following aspects are covered: the structure of the intestinal wall barrier; the influence of the gut microbiota on the permeability of the intestinal wall via the regulation of functioning of tight junction proteins, synthesis/degradation of mucus and antioxidant effects; the molecular mechanisms of activation of the pro-inflammatory response caused by bacterial invasion through the TLR4-induced TIRAP/MyD88 and TRAM/TRIF signaling cascades; the influence of nutrition on intestinal permeability, and the influence of exercise with an emphasis on exercise-induced heat stress and hypoxia. Overall, this review provides some insight into how to prevent excessive intestinal barrier permeability and the associated inflammatory processes involved in many if not most pathologies. Some diets and physical exercise are supposed to be non-pharmacological approaches to maintain the integrity of intestinal barrier function and provide its efficient operation. However, at an early age, the increased intestinal permeability has a hormetic effect and contributes to the development of the immune system.

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Section: Intestinal Permeabilitymentioning

confidence: 99%

Section: Intestinal Permeabilitymentioning

confidence: 99%