High glucose impairs superoxide production from isolated blood neutrophils

Perner, Anders; Nielsen, Sara Elsøe; Rask-Madsen, J

doi:10.1007/s00134-002-1628-4

Cited by 167 publications

(99 citation statements)

References 12 publications

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“…Impaired neutrophil function resulting in decreased intracellular bactericidal activity, opsonic activity, and innate immunity has also been reported. 29 Such effects could theoretically modulate the intense inflammation associated with respiratory organ dysfunction and may explain the decrease in respiratory dysfunction, but what the effects contribute to the increased incidence of other organ dysfunctions, such as renal failure, is not known. Further studies on these differential effects are needed.…”

Section: Wwwajcconlineorgmentioning

confidence: 99%

Respiratory Dysfunction in Patients With Sepsis: Protective Effect of Diabetes Mellitus

Yang

Salam

Ong

et al. 2011

American Journal of Critical Care

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Background Sepsis is a common complication in patients with diabetes mellitus. In a Western population, risk of respiratory dysfunction was lower in diabetic patients with sepsis. Objective To compare organ dysfunction, particularly respiratory dysfunction, between sepsis patients with and without diabetes mellitus in an Asian population. Method Hospital discharge data were collected for the period 2004 through 2008. Patients with sepsis, diabetes mellitus, and organ dysfunction were identified by using the International Statistical Classification of Diseases and Related Health Problems, 9th Revision, Australian Modification codes. Results Of the 383 238 patients hospitalized during the 5 years, 2943 of the 9221 who had sepsis also had diabetes (31.9%).The most common organ dysfunctions in patients with sepsis were renal (31.5%), cardiovascular (19.2%), and respiratory (10.9%). Among patients with sepsis, respiratory dysfunction was less likely in patients with diabetes (9.4%) than in those without (11.6%; P = .002), but renal dysfunction was more likely in patients with diabetes (46.5%) than in those without (24.4%; P < .001). However, only 27.6% of patients with diabetes had a respiratory source of sepsis compared with 33.4% in patients without diabetes (P < .001). Among patients with sepsis, diabetes mellitus was a significant and independent predictor of respiratory dysfunction (odds ratio, 0.80; 95% confidence interval, 0.66–0.98) after adjustments for age, sex, ethnicity, admission to intensive care, number of comorbid conditions, and other infection sources. Conclusion Among an Asian population, respiratory dysfunction in patients with sepsis is less likely to develop in those with diabetes than in those without diabetes.

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Section: Wwwajcconlineorgmentioning

confidence: 99%

Respiratory Dysfunction in Patients With Sepsis: Protective Effect of Diabetes Mellitus

Yang

Salam

Ong

et al. 2011

American Journal of Critical Care

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“…The Leuven study of nondiabetic ICU patients showed that maintaining normoglycemia with insulin prevents severe nosocomial infections and lethal sepsis (10). Polymorphonuclear neutrophil dysfunction (50), decreased intracellular bactericidal (51,52) and opsonic activity (50,53) following exposure to high concentrations of glucose, as well as nonenzymatic glycosylation of immunoglobulins (54) may play a role in the increased incidence of infections in patients with hyperglycemia. In an animal model of prolonged critical illness induced by trauma (55), it was recently shown that maintaining normoglycemia with insulin indeed rapidly affected innate immunity by preserving phagocytosis and oxidative burst function of monocytes (56).…”

Section: Figurementioning

confidence: 99%

How does blood glucose control with insulin save lives in intensive care?

Berghe¹

2004

J. Clin. Invest.

470

247

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Patients requiring prolonged intensive care are at high risk for multiple organ failure and death. Insulin resistance and hyperglycemia accompany critical illness, and the severity of this "diabetes of stress" reflects the risk of death. Recently it was shown that preventing hyperglycemia with insulin substantially improves outcome of critical illness. This article examines some potential mechanisms underlying prevention of glucose toxicity as well as the effects of insulin independent of glucose control. Unraveling the molecular mechanisms will provide new insights into the pathogenesis of multiple organ failure and open avenues for novel therapeutic strategies.

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“…50% decreased ROS generation was detected at 25 mM glucose [13]. Lowering of blood glucose levels by insulin treatment of diabetic patients improved neutrophil functional activity [20].…”

Section: Discussionmentioning

confidence: 92%

“…There has already been evidence that glucose can alter blood ROS generation [12][13][14][15][16][17][18][19]: 11 mM glucose reduced the neutrophils' respiratory burst by 28% ± 5% and 56 mM glucose by 74% ± 7% [12]. 50% decreased ROS generation was detected at 25 mM glucose [13].…”

Section: Discussionmentioning

confidence: 99%

Glucose initially inhibits and later stimulates blood ROS generation

Stief¹

2013

JDM

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High glucose impairs superoxide production from isolated blood neutrophils

Cited by 167 publications

References 12 publications

Respiratory Dysfunction in Patients With Sepsis: Protective Effect of Diabetes Mellitus

Respiratory Dysfunction in Patients With Sepsis: Protective Effect of Diabetes Mellitus

How does blood glucose control with insulin save lives in intensive care?

Glucose initially inhibits and later stimulates blood ROS generation

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