High-grade chondrosarcoma of the larynx: a case report and literature review

Waters, Darragh; Elliott, Jessie A; O’Duffy, Fergal; O'Dwyer, T

doi:10.1093/jscr/rjy222

Cited by 9 publications

(10 citation statements)

References 8 publications

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“…After study selection according to the PRISMA 2020 guidelines, 7 31 studies with 41 patients with laryngeal conventional chondrosarcomas met the criteria for the systematic review (Figure 1). 3,4,9–37 The year of publication of the studies included in this review ranged from 1988 to 2021. With an additional 14 cases in our institution (Table 1), the final study cohort included 55 cases.…”

Section: Resultsmentioning

confidence: 99%

Imaging features of laryngeal chondrosarcomas: A case series and systematic review

Baba

Kurokawa

et al. 2022

Journal of Neuroimaging

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Background and Purpose To comprehensively summarize the characteristics of radiological findings of laryngeal conventional chondrosarcomas. Methods We included patients with pathologically proven laryngeal conventional chondrosarcomas with CT and /or MRI, including 41 cases from 31 publications recruited after a systematic review and 14 cases from our institution. Two board‐certified radiologists reviewed and evaluated all the radiological images. The relationship between pathological grade and radiological findings was analyzed. Results The median long diameter of the lesion was 3.1 cm (range, 1.5‐8.5 cm). The most common location was the cricoid (74.5%), followed by the thyroid (12.7%), cricoid and thyroid (7.3%), and arytenoid (5.5%). All lesions showed well‐defined margins. Cortical defect/expansion (98.0%), internal low density (89.6%), and calcification (95.8%) with homogeneous and scarce contrast enhancement on contrast‐enhanced CT (85.3%) were frequently observed. All cases showed high signal on T2‐weighted imaging, low signal on T1‐weighted imaging (T1WI), and heterogeneous and mild contrast enhancement on postcontrast T1WI. No significant differences were found between the pathological grades and radiological findings. Conclusions In our summary of comprehensive CT and MRI findings of laryngeal conventional chondrosarcomas, we found that the knowledge of these radiological features may facilitate prompt diagnosis and appropriate management.

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Section: Resultsmentioning

confidence: 99%

Imaging features of laryngeal chondrosarcomas: A case series and systematic review

Baba

Kurokawa

et al. 2022

Journal of Neuroimaging

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“…Although the most chondrosarcomas are low grade and are not characterized by aggressive behavior, recurrence rate is reported to be between 18 and 40%. On the other hand, high-grade chondrosarcomas have 70% higher metastatic potential, compared to low-grade chondrosarcomas and are associated with poorer prognosis and 10-year survival rate of 29% [2]. LLMSs showed recurrence rate of 30% with five-year survival rate of 50% [15], whereas mean time to locoregional LOS recurrence and LOS distant metastasis is five months and 12 months, respectively [7].…”

Section: Discussionmentioning

confidence: 99%

“…Laryngeal chondrosarcoma (LCS) arises from cricoid cartilage in 80% of cases [2]. LCSs present with hoarseness in most of the cases.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, primary sarcomas are uncommonly seen in larynx and comprise around 1 % of all laryngeal malignant tumors [1]. Considering the low incidence of laryngeal sarcomas, most of the literature data are obtained from single case reports and scanty [2,3,4]. The fact that they differ a lot in their biological behavior from SCC is what makes the accurate diagnosis essential in their management.…”

Section: Introductionmentioning

confidence: 99%

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Primary sarcomas of the larynx: A report of three cases and literature review

et al. 2022

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Introduction. Primary sarcomas are uncommonly seen in larynx and comprise around 1% of all laryngeal malignant tumors. We present three cases of patients with different types of laryngeal sarcomas and discuss about diagnostic and treatment difficulties. Case outline. Each patient presented with hoarseness and shortness of breath. Computed tomography scans showed large transglottic tumors of the larynx with no signs of cervical lymphadenopathy and definitive diagnoses of sarcomas were made by pathologists. Each patient underwent total laryngectomy with clear resection margins. Patient with laryngeal leiomyosarcoma developed large locoregional relapse of malignant disease and pulmonary metastasis four months after surgery and patient with laryngeal osteosarcoma was diagnosed with inoperative locoregional relapse of malignant disease three months after surgery. Both patients died within six months after surgery. On the other hand, patient with laryngeal chondrosarcoma was disease-free during three-year follow-up. Conclusion. Primary laryngeal sarcomas have low incidence and they differ from SCC by their biological characteristics and behavior. Radical surgical resection remains the mainstay of treatment with uncertain outcome due to their high potential for recurrence or metastatic spread.

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“…High-grade chondrosarcomas are rare [24]. This tumor type shows striking cellularity and cytologic atypia, and plump binucleated and multinucleated cells are often seen.…”

Section: Chondrosarcomamentioning

confidence: 99%

Differing characteristics of cartilaginous lesions of the larynx

Ferlito¹,

Devaney

Mäkitie

2019

Eur Arch Otorhinolaryngol

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IntroductionThe tissues of the laryngeal region only rarely harbor primary cartilaginous lesions, and squamous cell carcinoma remains the most frequently encountered malignant tumor in this area.Materials and MethodsWe reviewed the salient histological features of cartilaginous laryngeal lesions to provide differential diagnostics and guidelines for distinguishing the benign from the malignant ones.ResultsCartilaginous neoplasms of the larynx include chondroma and chondrosarcoma. Among the overarching group of all forms of laryngeal sarcoma, chondrosarcoma forms the most common entity in the larynx, followed by rhabdomyosarcoma. Cartilaginous tumors comprise about 0.1%–1% of all laryngeal neoplasms with chondrosarcomas being more frequently encountered than chondromas. Several neoplasms earlier reported as giant-cell tumors of the larynx would most likely, using current terminology, be classified as cases of undifferentiated pleomorphic sarcoma (previously known as malignant fibrous histiocytoma, giant-cell variant) or aneurysmal bone cyst.ConclusionWhen true laryngeal sarcomas do exist, they may prove to be challenging lesions both for the pathologist and the treating clinician. The diagnostic problems are mainly a result of the infrequent exposure of clinicians and diagnosticians to these lesions.

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High-grade chondrosarcoma of the larynx: a case report and literature review

Cited by 9 publications

References 8 publications

Imaging features of laryngeal chondrosarcomas: A case series and systematic review

Imaging features of laryngeal chondrosarcomas: A case series and systematic review

Primary sarcomas of the larynx: A report of three cases and literature review

Differing characteristics of cartilaginous lesions of the larynx

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