High-grade intraventricular astroblastoma in a young adult: A rare and controversial tumor to manage

Abstract

Astroblastoma is a rare primary central nervous system tumor of controversial site of origin. They account for 0.45-2.8% of all primary neuroepithelial central nervous system. It has been reported in paediatric age group with bimodal age distribution affecting more females with male to female ratio being 1:11. Astroblastomas are controversial and challenging tumors in terms of diagnosis and therapeutics. Since it carries an unpredictable disease course it needs a regular follow up even for low grade tumor. Authors have tried various schedules of post op radiotherapy after maximum safe resection. Various chemotherapeutic drugs combination have also been tried without much success. We here report a 35 years old female patient who was diagnosed with high grade astroblastoma referred for post-operative radiotherapy after gross total resection. Since it is extremely rare tumor, its treatment still not well defined and also makes it difficult conduct studies to examine tumor characteristics.

Cerebral astroblastoma radiologically mimicking pilocytic astrocytoma: A case report

“…It is most commonly seen in patients less than 5 years of age with mean and median age at diagnosis varying from 14.5 to 18 and 14 years respectively. 6 , 7 , 8 Astroblastoma shows female preponderance with female to male ratio of 1.7–8:1. 7 , 8 …”

“…It is most commonly seen in patients less than 5 years of age with mean and median age at diagnosis varying from 14.5 to 18 and 14 years respectively. [6][7][8] Astroblastoma shows female preponderance with female to male ratio of 1.7-8:1. 7,8 Astroblastoma is commonly located in supratentorial region mainly in frontal region but it is also reported from parietal, occipital, intraventricular, brain stem, spinal cord, and sometimes extra-axial.…”

“…Exact clinicoepidemiological findings for the diagnosis and management of astroblastoma are insufficient to guide the maximal patient care due to its rarity and limited available study. It is most commonly seen in patients less than 5 years of age with mean and median age at diagnosis varying from 14.5 to 18 and 14 years respectively 6‐8 . Astroblastoma shows female preponderance with female to male ratio of 1.7–8:1 7,8 …”

Navigating the Diagnosis and Treatment of Astroblastoma: A Pediatric Case Report

“…The origin of these tumors has been a subject of debate, as they exhibit similar histological features to ependymomas and astrocytomas [ 5 ]. Currently, gross total resection is generally regarded as the primary treatment approach, although chemotherapy and radiotherapy have demonstrated benefits, their exact roles remain undefined [ 6 ]. This case report addresses the diagnostic and therapeutic challenges of astroblastoma, a rare glial tumor of the central nervous system.…”