High‐grade lymphoma of the ileoanal pouch in an HIV‐positive patient

Jones, Oliver; McCutcheon, Jodie Anita; Herieka, E; Fozard, J. B. J.

doi:10.1111/j.1463-1318.2006.00962.x

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…However, other studies found no link with pouch dysplasia [87]. More anecdotally, other pouch and ATZ malignancies have been reported such as squamous cell carcinoma [63,66,69,[106][107][108][109][110], pouch lymphoma [29,63,99,[111][112][113][114][115][116][117], carcinoid tumour of the pouch [118,119] and malignant melanoma [120]. Moreover, the Danish nationwide cohort found a higher risk of non-melanoma skin and hepatobiliary cancers in patients undergoing IPAA for UC than in the gender-and age-matched comparison cohort of patients from a national civil database [106].…”

Section: Epidemiology and Risk Factorsmentioning

confidence: 98%

Incidence and Risk Factors of Cancer in the Anal Transitional Zone and Ileal Pouch following Surgery for Ulcerative Colitis and Familial Adenomatous Polyposis

Cosquer

Buscail

Gilletta

et al. 2022

Cancers

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Proctocolectomy with ileal pouch-anal anastomosis is the intervention of choice for ulcerative colitis and familial adenomatous polyposis requiring surgery. One of the long-term complications is pouch cancer, having a poor prognosis. The risk of high-grade dysplasia and cancer in the anal transitional zone and ileal pouch after 20 years is estimated to be 2 to 4.5% and 3 to 10% in ulcerative colitis and familial polyposis, respectively. The risk factors for ulcerative colitis are the presence of pre-operative dysplasia or cancer, disease duration > 10 years and severe villous atrophy. For familial polyposis, the risk factors are the number of pre-operative polyps > 1000, surgery with stapled anastomosis and the duration of follow-up. In the case of ulcerative colitis, a pouchoscopy should be performed annually if one of the following is present: dysplasia and cancer at surgery, primary sclerosing cholangitis, villous atrophy and active pouchitis (every 5 years without any of these factors). In the case of familial polyposis, endoscopy is recommended every year including chromoendoscopy. Even if anal transitional zone and ileal pouch cancers seldom occur following proctectomy for ulcerative colitis and familial adenomatous polyposis, the high mortality rate associated with this complication warrants endoscopic monitoring.

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