2021
DOI: 10.1101/2021.08.24.457387
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High-grade Ovarian Cancer Associated H/ACA snoRNAs Promote Cancer Cell Proliferation and Survival

Abstract: Small nucleolar RNAs (snoRNAs) are an omnipresent class of non-coding RNAs involved in the modification and processing of ribosomal RNA (rRNA). As snoRNAs are required for ribosome production, the increase of which is a hallmark of cancer development, their expression would be expected to increase in proliferating cancer cells. However, the nature and extent of snoRNAs contribution to the biology of cancer cells remain largely unexplored. In this study, we examined the abundance patterns of snoRNA in high-grad… Show more

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“…These snoRNAs are classified in two major families: the C/D and H/ACA classes, which guide 2′-O-methylation and pseudouridylation of their substrates, respectively. The importance of correct snoRNA expression is underscored by the fact that defects in snoRNA metabolism are linked to multiple pathologic processes including cancer 4,5 , Prader-Willi syndrome 6 , and metabolic stress 7 . SnoRNAs are found in many different genomic contexts 2,8 .…”
Section: Introductionmentioning
confidence: 99%
“…These snoRNAs are classified in two major families: the C/D and H/ACA classes, which guide 2′-O-methylation and pseudouridylation of their substrates, respectively. The importance of correct snoRNA expression is underscored by the fact that defects in snoRNA metabolism are linked to multiple pathologic processes including cancer 4,5 , Prader-Willi syndrome 6 , and metabolic stress 7 . SnoRNAs are found in many different genomic contexts 2,8 .…”
Section: Introductionmentioning
confidence: 99%