High-grade primary pulmonary leiomyosarcoma

Sardenberg, Rodrigo Afonso da Silva; Neto, Renato Cangnaci; Cavalcanti, Fernanda Tavares De Melo; Younes, Riad Naim

doi:10.1590/s1679-45082011rc1773

Cited by 7 publications

(17 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…If a tumor is discovered in this region in a patient free from significant exposure to tobacco smoke, the possibility of a leiomyosarcoma becomes more distinct. 1 In making the diagnosis of PPL, it is important to first rule out the possibility of a secondary source of the neoplasm, especially considering that extrapulmonary sarcoma metastases are more common than tumors of primary origin. 6 Histological examination of tissue samples remains the standard for diagnosing PPLs, 5 especially considering the difficulty of obtaining useful data from other modalities.…”

Section: Diagnosismentioning

confidence: 99%

Bilateral Primary Pulmonary Leiomyosarcoma: A Case Report

Magovern

Wachs

Malatack

2019

Georgetown Medical Review

View full text Add to dashboard Cite

Introduction: Primary pulmonary leiomyosarcomas are a group of rare malignant tumors. They are subdivided into those originating from pulmonary parenchyma, bronchial tree, or pulmonary arteries. They tend to expand locally, and presentation depends on the site of the tumor. Diagnosis can be challenging. Case Presentation: A 40-year-old woman presented with dyspnea and severe sepsis due to a lung mass and postobstructive pneumonia. She was diagnosed as having bilateral endobronchial primary pulmonary leiomyosarcoma and treated with bilobectomy; however, she died shortly after surgery due to complications. Conclusion: Considering the rarity of her condition, this case offers a unique opportunity to investigate its presentation, diagnosis, and treatment strategies through a study of the literature.

show abstract

Section: Diagnosismentioning

confidence: 99%

Bilateral Primary Pulmonary Leiomyosarcoma: A Case Report

Magovern

Wachs

Malatack

2019

Georgetown Medical Review

View full text Add to dashboard Cite

show abstract

“…Clinical and radiological examinations have found no evidence of an alternative primary source in the current case. As with soft tissue sarcomas of the extremities, a large size (>5 cm) and high grade of PLS are reportedly associated with worse patient survival 4,17. The small tumor targeted by SABR in the present patient may help explain the favorable outcome.…”

Section: Discussionmentioning

confidence: 61%

Primary lung sarcoma treated with stereotactic ablative radiotherapy: a case report

Yeo¹

2017

OTT

View full text Add to dashboard Cite

Primary lung sarcoma (PLS) is an extremely rare, very aggressive malignancy. Surgical removal is considered the treatment of choice, and patients who have been given conventional radiotherapy have had inferior outcomes. This study is the first describing a case of PLS treated with stereotactic ablative radiotherapy (SABR), which precisely targets a small tumor with a markedly higher biologically effective dose than conventional radiotherapy. The patient was an 82-year-old man who was diagnosed with primary lung leiomyosarcoma based on radiology, pathology, and immunohistochemical examinations. The PLS was located in the right lower lobe and measured 2.5 cm. No regional nodal or distant organ metastasis was observed. He was inoperable medically. The SABR was performed using volumetric modulated arc therapy and a dose of 56 Gy in four fractions. Follow-up computed tomography 2 months after SABR revealed a complete tumor response. The toxicity was limited to mild respiratory symptoms. The patient is alive and has had no evidence of disease for 2 years. This study suggests that SABR can be a safe and effective treatment option for PLS.

show abstract

“…It has been found in the bronchus (20%), lung parenchyma (70%), or pulmonary arteries (10%) and is considered rare, accounting for only 0.5% of all lung malignancies. [5] The patients with PAS often have a poor prognosis. The median survival time of PAS without therapy is around 1.5 months, and the reported longest survival period was 3 years.…”

Section: Discussionmentioning

confidence: 99%

Primary pulmonary artery sarcoma with deep vein thrombosis

Li¹,

Liang

et al. 2019

Medicine

View full text Add to dashboard Cite

Rationale: Pulmonary artery sarcomas (PAS) are easily misdiagnosed as thromboembolic disease of pulmonary arteries, because of rarity and presenting with nonspecific signs, symptoms, or imaging findings. Patient concerns: A 26-year-old man was admitted to the department of invasive technology with fever and dyspnea. Blood tests showed inflammatory activity, a slight increase of D-dimer and Fibrin Degradation Product. A chest enhanced computed tomography (CT) scanning revealed multiple filling defects occurred in the main trunk of both pulmonary arteries and branches of the left pulmonary artery Diagnoses: It was initially diagnosed with pulmonary embolism (PE) and deep vein thrombosis (DVT), but was eventually diagnosed with pulmonary artery sarcoma that was confirmed by biopsy. Interventions: The transcatheter thrombolysis therapy, inferior vena cava filter implantation, and operation were performed. Outcomes: The Organized mass was removed by the operation and was pathologically diagnosed as pulmonary artery sarcoma, the patient received postoperative chemotherapy according to the recommendation of oncology department. Lessons: Coagulation markers have been reported to differentiate PAS from PE, but this case suggested that PAS can be associated with DVT and abnormal coagulation-fibrinolysis system.

show abstract

High-grade primary pulmonary leiomyosarcoma

Cited by 7 publications

References 8 publications

Bilateral Primary Pulmonary Leiomyosarcoma: A Case Report

Bilateral Primary Pulmonary Leiomyosarcoma: A Case Report

Primary lung sarcoma treated with stereotactic ablative radiotherapy: a case report

Primary pulmonary artery sarcoma with deep vein thrombosis

Contact Info

Product

Resources

About