High‐grade prostate intraepithelial neoplasia shares cytogenetic alterations with invasive prostate cancer

Alcaraz, Antonio; Barranco, Miguel Angel Molinero; Corral, Juan Manuel; Ribal, María J.; Carrió, Ana; Mallofré, Carme; Sanchís, Juan; Cetina, Alfredo; Álvarez-Vijande, R.

doi:10.1002/pros.1044.abs

Cited by 3 publications

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“…34,37,39 Gain of chromosomes 7 and 8, selective amplification of 7q31 and c-myc, and high-level marker ARs were more common in patients with follow-up cancer than in those who did not progress to cancer, a finding supported by other studies. 22, [30][31][32][33][34]40,41,49 Recalculating composite scores for groups A and B based only on chromosome 7 (7q31) and 8 (c-myc) CNAs and excluding chromosome 17 (HER-2/neu) data did not increase the predictive value of finding cancer on a follow-up biopsy compared with the original calculation, which was based on data from all 3 chromosomes. Copy number heterogeneity was a common finding in HGPIN lesions within individual patients.…”

Section: Discussionmentioning

confidence: 99%

“…[17][18][19][20][21][22] Interphase FISH using pericentromeric probes, comparative genomic hybridization, and molecular loss of heterozygosity analyses have identified nonrandom numerical abnormalities of multiple chromosomes. [17][18][19][20][21][22][29][30][31][32][33][34][36][37][38][39][40][41][42]45,46,49,51 The most commonly reported genetic alterations in HGPIN and carcinoma based on these methods include (1) gains of chromosome 7, particularly 7q31; (2) loss of 8p and gain of 8q;…”

Section: Discussionmentioning

confidence: 99%

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Use of interphase fluorescence in situ hybridization in prostate needle biopsy specimens with isolated high-grade prostatic intraepithelial neoplasia as a predictor of prostate adenocarcinoma on follow-up biopsy

et al. 2004

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Use of interphase fluorescence in situ hybridization in prostate needle biopsy specimens with isolated high-grade prostatic intraepithelial neoplasia as a predictor of prostate adenocarcinoma on follow-up biopsy

et al. 2004

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“…The evidence linking PIN to invasive prostate cancer is overwhelming (reviewed in [Bostwick and Eble, 1997]) and includes the cytologic similarity of the relatively uniform and distinctive cells in PIN with those of adjacent invasive cancer, their frequent spatial relationship, the similar immunohistochemical reactivities shared by PIN and invasive cancer, the sharing of genetic abnormalities by PIN and concomitant cancer [Alcaraz et al, 2001], and strong epidemiological associations. Some prostatic adenocarcinomas could conceivably arise independently from the clones of PIN, but a reasonable estimate is that half or more prostate adenocarcinomas evolve from clones of PIN.…”

Section: Pin Is a Precursor To Some Forms Of Invasive Prostate Carcinomamentioning

confidence: 99%

Molecular aspects of diagnostic nucleolar and nuclear envelope changes in prostate cancer

Fischer

Bardarov

Jiang

2003

J of Cellular Biochemistry

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Prostate cancer is still diagnosed by pathologists based on subjective assessment of altered cell and tissue structure. The cellular-level structural changes diagnostic of some forms of cancer are known to be induced by cancer genes, but the relation between specific cellular-level structural features and cancer genes has not been explored in the prostate. Two important cell structural changes in prostate cancer-nucleolar enlargement and nuclear envelope (NE) irregularity-are discussed from the perspective that they should also relate to the function of the genes active in prostate cancer. Enlargement of the nucleolus is the key diagnostic feature of high-grade prostatic intraepithelial neoplasia (PIN), an early stage that appears to be the precursor to the majority of invasive prostate cancers. Nucleolar enlargement classically is associated with increased ribosome production, and production of new ribosomes appears essential for cell-cycle progression. Several cancer genes implicated in PIN are known (in other cell types) to augment ribosome production, including c-Myc, p27, retinoblastoma, p53, and growth factors that impact on ERK signaling. However, critical review of the available information suggests that increased ribosome production per se may be insufficient to explain nucleolar enlargement in PIN, and other newer functions of nucleoli may therefore need to be invoked. NE irregularity develops later in the clonal evolution of some prostate cancers, and it has adverse prognostic significance. Nuclear irregularity has recently been shown to develop dynamically during interphase following oncogene expression, without a requirement for post-mitotic NE reassembly. NE irregularity characteristic of some aggressive prostate cancers could reflect cytoskeletal forces exerted on the NE during active cell locomotion. NE irregularity could also promote chromosomal instability because it leads to chromosomal asymmetry in metaphase. Finally, NE irregularity could impact replication competence, transcriptional programming and nuclear pore function.

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Fluorescence in situ hybridization analysis of matched primary tumour and lymph‐node metastasis of D1 (pT2–3pN1M0) prostate cancer

et al. 2004

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nuclei obtained from matched primary tumours and their lymph node metastases. RESULTSOf the 28 suitable cases it was possible to complete the study in 18 pairs of matched tissues; the remainder were excluded because of insufficient tissue or poor preservation of at least one of the tissues. There was cytogenetic change (aneuploidy) in 16 of the 18 primary tumours, the most common being monosomy 8, detected in 14, followed by trisomy 7, in 13 aneuploid tumours. All lymph node metastases were aneuploid by FISH. As in the primary tumours, monosomy 8 and trisomy 7 were the most common cytogenetic alterations, in 13 and 15 of the lymph node tissues. FISH analysis showed a high correlation (83%) in the cytogenetic pattern of changes between the primary tumours and their lymph node metastases. Moreover, a similar number of cells had the most common aneusomies when comparing prostate and the lymph node tissues. CONCLUSIONSThese results show a similar pattern of cytogenetic alteration in the primary tumour and its lymph node metastasis, characterized by the frequent presence of trisomy 7 and monosomy 8, suggesting that clonal cell selection is not involved in the metastatic process.

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High‐grade prostate intraepithelial neoplasia shares cytogenetic alterations with invasive prostate cancer

Cited by 3 publications

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Use of interphase fluorescence in situ hybridization in prostate needle biopsy specimens with isolated high-grade prostatic intraepithelial neoplasia as a predictor of prostate adenocarcinoma on follow-up biopsy

Use of interphase fluorescence in situ hybridization in prostate needle biopsy specimens with isolated high-grade prostatic intraepithelial neoplasia as a predictor of prostate adenocarcinoma on follow-up biopsy

Molecular aspects of diagnostic nucleolar and nuclear envelope changes in prostate cancer

Fluorescence in situ hybridization analysis of matched primary tumour and lymph‐node metastasis of D1 (pT2–3pN1M0) prostate cancer

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