High-Grade Prostatic Intraepithelial Neoplasia in Dogs

Waters, David J.

doi:10.1159/000019878

“…[141][142][143][144][145] High-grade PIN has been also observed in the prostates of these animals. [142][143][144][145] Canine high-grade PIN shows cytological features identical to the human counterpart, including cell crowding, loss of polarity, and nuclear and nucleolar enlargement. Like prostatic adenocarcinoma, high-grade PIN also increases with aging.…”

Section: Animal Models Of Pin and Prostate Cancermentioning

confidence: 99%

“…Like prostatic adenocarcinoma, high-grade PIN also increases with aging. 142 Highgrade PIN appears to represent an early event in prostate carcinogenesis that occurs with high frequency within the prostates of pet dogs sharing the same environment as humans. In this model, highgrade PIN was determined to be an intermediate step between benign epithelium and invasive carcinoma.…”

Section: Animal Models Of Pin and Prostate Cancermentioning

confidence: 99%

High-grade prostatic intraepithelial neoplasia

Bostwick

¹

,

Qian

²

2004

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High-grade prostatic intraepithelial neoplasia (PIN) is now accepted as the most likely preinvasive stage of adenocarcinoma, almost two decades after its first formal description. PIN has a high predictive value as a marker for adenocarcinoma, and its identification warrants repeat biopsy for concurrent or subsequent invasive carcinoma. The only method of detection is biopsy; PIN does not significantly elevate serum prostate-specific antigen (PSA) concentration or its derivatives and cannot be detected by current imaging techniques, including ultrasound. Most patients with PIN will develop carcinoma within 10 years. PIN is associated with progressive abnormalities of phenotype and genotype, which are similar to cancer rather than normal prostatic epithelium, indicating impairment of cell differentiation with advancing stages of prostatic carcinogenesis. Androgen deprivation therapy decreases the prevalence and extent of PIN, suggesting that this form of treatment may play a role in chemoprevention.

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“…The dog is the only nonhuman species in which spontaneous prostate cancer occurs, and, like humans, the rate of canine prostate cancer increases with aging. [141][142][143][144][145] High-grade PIN has been also observed in the prostates of these animals. [142][143][144][145] Canine high-grade PIN shows cytological features identical to the human counterpart, including cell crowding, loss of polarity, and nuclear and nucleolar enlargement.…”

Section: Animal Models Of Pin and Prostate Cancermentioning

confidence: 99%

High-grade prostatic intraepithelial neoplasia

Bostwick¹,

Qian²

2004

View full text Add to dashboard Cite

High-grade prostatic intraepithelial neoplasia (PIN) is now accepted as the most likely preinvasive stage of adenocarcinoma, almost two decades after its first formal description. PIN has a high predictive value as a marker for adenocarcinoma, and its identification warrants repeat biopsy for concurrent or subsequent invasive carcinoma. The only method of detection is biopsy; PIN does not significantly elevate serum prostate-specific antigen (PSA) concentration or its derivatives and cannot be detected by current imaging techniques, including ultrasound. Most patients with PIN will develop carcinoma within 10 years. PIN is associated with progressive abnormalities of phenotype and genotype, which are similar to cancer rather than normal prostatic epithelium, indicating impairment of cell differentiation with advancing stages of prostatic carcinogenesis. Androgen deprivation therapy decreases the prevalence and extent of PIN, suggesting that this form of treatment may play a role in chemoprevention.

show abstract

“…Wholegenome association studies are ongoing for a host of canine cancers that are of interest for human health and biology, including osteosarcoma, lymphoma, transitional cell carcinoma, soft tissue cancer, and squamous cell carcinomas; each study centered around a carefully chosen set of breeds. Finally, as several investigators have shown (43), including Antuofermo et al (1), dogs experience many of the same precursor syndromes that herald metastatic disease in humans. Therefore, a clearer understanding of canine cancer syndromes will almost certainly lead to a better understanding of the key steps in the formation of human tumors.…”

mentioning

confidence: 91%