High Grade Serous Cystadenocarcinoma of Testis- Case Report of a Rare Ovarian Epithelial Type Tumour

Abstract

A 67-year-old male patient presented to our surgical oncology outpatient department, with lower abdominal pain and right scrotal swelling, gradually increasing in size for two months duration. He gave a history of reduced appetite and weight loss with regular bowel and bladder habits. He was on steroid inhalers and long acting β agonist for more than five years as treatment for Chronic Obstructive Airway Disease (COPD).

High-grade metastatic paratesticular cystadenocarcinoma

“…Usually, these tumors are found in a paratesticular location and can reach patients in distinctive ages, ranging from 16 to 87 years old. 1 , 2 …”

“…Of the reported cases without adjuvant therapy, 19% developed metastasis after 48–84 months of follow up. 1 , 2 Due to paucity of reports and absence of long term follow up we cannot estimate survival rates.…”

“… 1 Clinical presentation is scrotal enlargement with no significant pain. 2 Ultrasound often shows a hypoechoic vascularized mass, with variable amounts of hydrocele. CT and MRI are not able to differentiate this tumor from other differential diagnosis.…”

Ovarian-type Tumors (Mullerian Tumors) of the Testis: Clinicopathologic Findings with Recent Advances

“…However, in all cases authors reported negative staining for mesothelial markers (such as calretinin, D2-40, and thrombomodulin), mesonephric markers (such as GATA3 and CD10), and germ cell markers (such as OCT4 and placental alkaline phosphatase [PLAP]) [5,20]. Ki-67 proliferation index has been reported as less than 1% in serous cystadenoma, 5.5% in serous borderline tumor, and up to 80-85% in serous carcinoma [6,10,38].…”

“…Generally, the clinical course of benign and borderline serous tumors is very favorable, with no reports of recurrence or metastasis following complete orchiectomy. Prognosis for serous carcinoma is more guarded, with reports of metastatic disease to the lymph nodes, peritoneum, lungs, adrenal glands, and leptomeninges [37][38][39][40]45]. Overall, metastasis occurred in 26% of reported serous carcinoma cases, and death from disease followed in half of those cases.…”