2022
DOI: 10.1016/j.anndiagpath.2021.151889
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High-grade transformation of low-grade biphenotypic sinonasal sarcoma: Radiological, morphophenotypic variation and confirmatory molecular analysis

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Cited by 15 publications
(14 citation statements)
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“…An intraarticular SS usually develops in the frontal part of the knee joint (fat pad of Hoffa) [4] . MRI has a superior soft-tissue resolution and is considered the “gold” imaging modality for evaluating the characteristics and extent of SS [7] , [8] , [9] , [10] , [11] , [12] , [13] . Typically, synovial sarcoma appears as an inhomogeneous multilobulated soft-tissue tumor on T1-weighted sequences, with signal intensity similar to or slightly higher than normal muscles [14 , 15] .…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…An intraarticular SS usually develops in the frontal part of the knee joint (fat pad of Hoffa) [4] . MRI has a superior soft-tissue resolution and is considered the “gold” imaging modality for evaluating the characteristics and extent of SS [7] , [8] , [9] , [10] , [11] , [12] , [13] . Typically, synovial sarcoma appears as an inhomogeneous multilobulated soft-tissue tumor on T1-weighted sequences, with signal intensity similar to or slightly higher than normal muscles [14 , 15] .…”
Section: Discussionmentioning
confidence: 99%
“…PD-weighted sequence creates contrast generally by reducing the effect of T1 and T2 differences with longer repetition times (2000-5000 ms) and shorter time to echo (10-20). Fluid levels have been reported in 10%-25% of synovial sarcomas cases [1 , 4 , 10 , 11] . In the presented case, cystic areas and hemorrhagic foci are visible in the joint space.…”
Section: Discussionmentioning
confidence: 99%
“…From the available description and figures, it seems that both cases showed a high-grade spindle cell morphology without the rhabdoid features detected in our case. Unfortunately, the first case was not tested for skeletal muscle markers at all [ 14 ], and the other was tested only for desmin and myogenin, both of which were focally positive in the high-grade areas of this case, suggesting differentiation into spindle cell RMS [ 15 ].…”
Section: Discussionmentioning
confidence: 99%
“…BSS are usually low-grade tumors with frequent local recurrence, sometimes many years after diagnosis [77]. Three cases of BSS with high-grade transformation have been published [78][79][80], one of which developed into rhabdomyosarcoma (RMS). Molecular testing of BSS and RMS showed similar gene fusions including PAX3::FOXO1 and PAX3::NCOA1 [74].…”
Section: Molecular Alterations With Differential Diagnostic Significancementioning
confidence: 99%