High-Gradient Magnetic Field for Magnetic Nanoparticles Drug Delivery System

Li, Da; Ren, Yong

doi:10.1109/tasc.2018.2836999

Cited by 15 publications

(7 citation statements)

References 24 publications

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“…External magnetic fields are the primary choice of stimulus due to their ease of use, low invasiveness, and control over the applied field conditions. A high-gradient field, which is static, but rapidly decreases in strength with distance from the source, can be used to overcome the hydrodynamic force of blood flow acting on drug carriers and is thus highly dependent on particle properties such as size and magnetic susceptibility 164 . Other important considerations for influencing the drug carrier trajectory include particle magnetization as well as drag and buoyancy forces 165 .…”

Section: Magnetic Systemsmentioning

confidence: 99%

Magnetic systems for cancer immunotherapy

Day

Wixson

Shields

2021

Acta Pharmaceutica Sinica B

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Immunotherapy is a rapidly developing area of cancer treatment due to its higher specificity and potential for greater efficacy than traditional therapies. Immune cell modulation through the administration of drugs, proteins, and cells can enhance antitumoral responses through pathways that may be otherwise inhibited in the presence of immunosuppressive tumors. Magnetic systems offer several advantages for improving the performance of immunotherapies, including increased spatiotemporal control over transport, release, and dosing of immunomodulatory drugs within the body, resulting in reduced off-target effects and improved efficacy. Compared to alternative methods for stimulating drug release such as light and pH, magnetic systems enable several distinct methods for programming immune responses. First, we discuss how magnetic hyperthermia can stimulate immune cells and trigger thermoresponsive drug release. Second, we summarize how magnetically targeted delivery of drug carriers can increase the accumulation of drugs in target sites. Third, we review how biomaterials can undergo magnetically driven structural changes to enable remote release of encapsulated drugs. Fourth, we describe the use of magnetic particles for targeted interactions with cellular receptors for promoting antitumor activity. Finally, we discuss translational considerations of these systems, such as toxicity, clinical compatibility, and future opportunities for improving cancer treatment.

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Section: Magnetic Systemsmentioning

confidence: 99%

Magnetic systems for cancer immunotherapy

Day

Wixson

Shields

2021

Acta Pharmaceutica Sinica B

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“…Although magnetic drug targeting is appealing, most studies demonstrate only in vitro results for superficial organs due to difficulties in manipulating magnetic particles in vivo and rapid decrease of magnetic force with distance [79]. While some technical challenges remain, several drug delivery systems have been developed for the treatment of pulmonary disorders [106,107], cancer [108][109][110], and cardiovascular diseases [111].…”

Section: Magnetic Constructs (A) or Constructs With Evenly Distributementioning

confidence: 99%

Magnetohydrodynamics in Biomedical Applications

Farrokhi¹,

Otuya²,

Khimchenko³

et al. 2020

Nanofluid Flow in Porous Media

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This chapter discusses recent advances in biomedical applications of magnetohydrodynamics (MHD). The magnetohydrodynamic (MDH) effect is a physical phenomenon describing the motion of a conducting fluid flowing under influencing of an external magnetic field. The chapter covers four primary areas of research: (1) laser beam scanning, (2) nano-particle manipulation, (3) imaging contrast enhancement, and (4) targeted drug delivery. The state-of-the-art devices based on magnetohydrodynamic principles are also presented, providing a broad view of biomedical MHDs. As the field of biomedical MHDs continues to grow, advances towards micro-scale transitions will continue to be made, maintaining its clinically driven nature and motion towards real-world applications.

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“…В этой технологии положительно заряженные магнитные наночастицы, предварительно покрытые отрицательно заряженным биологически активным агентом, вводятся в живую ткань и направляются к очагу болезни с помощью локального источника внешнего магнитного поля. Исследования такого рода проводятся в офтальмологии, при лечении злокачественных образований и в генетических экспериментах [6,7]. Так, в работе [8] описан процесс разработки ВТСП-2 СМС, генерирующей магнитное поле с градиентом 20−70 T/m для изучения процессов генного транспорта.…”

Section: Introductionunclassified

Высокотемпературная Сверхпроводниковая Магнитная Система Для Изучения Нейронной Активности

Диев¹,

Ковалев²,

Макаренко³

et al. 2022

Журнал Технической Физики

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The paper describes a high-temperature superconducting magnetic system (HTS SMS) to equip an experimental stand intended for neuron activity researches under constant and low-frequency magnetic fields up to 1 T. The design of the magnetic system together with its electromagnetic and cryogenic parameters is briefly discussed. The test results of the preliminary experiments conducted in liquid nitrogen at 77 K for two interchangeable magnets are given. The first magnet was manufactured in the form of a double pancake coil wound with 4 mm high HTS tape. The second magnet was made of pure copper wire with no frame and was impregnated with a thermally conducting epoxy resin. The advantages of the HTS pancake coil were demonstrated in comparison with the cryo-resistive solenoid. Low energy consumption of the HTS magnetic system will allow conducting continuous non-invasive monitoring of biological objects in a magnetic field.

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High-Gradient Magnetic Field for Magnetic Nanoparticles Drug Delivery System

Cited by 15 publications

References 24 publications

Magnetic systems for cancer immunotherapy

Magnetic systems for cancer immunotherapy

Magnetohydrodynamics in Biomedical Applications

Высокотемпературная Сверхпроводниковая Магнитная Система Для Изучения Нейронной Активности

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