High heart rate: More than a risk factor. Lessons from a clinical practice survey

Barrios, Vivencio; Escobar, Carlos; Bertoméu, Vicente; Murga, Nekane; Pablo, Carmen de; Asín, Enrique

doi:10.1016/j.ijcard.2008.05.045

Cited by 8 publications

(6 citation statements)

References 6 publications

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“…There is even more controversy about the relationship between heart rate and target organ damage. In a recent study, Cuspidi et al did not find conclusive data to support this relationship [22,25]. In our study we found that the lower heart rate is associated, in patients without pharmacological treatment, with higher target organ damage, except for renal damage, assessed by the albumin/creatinine ratio, which seems to be directly related to increased heart rate, and therefore the relationship between heart rate and target organ involvement is not clear.…”

Section: Discussioncontrasting

confidence: 84%

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Pulse pressure and nocturnal fall in blood pressure are predictors of vascular, cardiac and renal target organ damage in hypertensive patients (LOD-RISK study)

García‐Ortiz

Gómez‐Marcos

Martín‐Moreiras

et al. 2009

Blood Pressure Monitoring

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Section: Discussioncontrasting

confidence: 84%

“…Although a relationship has been found between heart rate and cardiovascular morbidity-mortality [22], there is still some controversy about the prognostic value of heart rate [23], particularly in hypertensive patients [24]. There is even more controversy about the relationship between heart rate and target organ damage.…”

Section: Discussionmentioning

confidence: 99%

Pulse pressure and nocturnal fall in blood pressure are predictors of vascular, cardiac and renal target organ damage in hypertensive patients (LOD-RISK study)

García‐Ortiz

Gómez‐Marcos

Martín‐Moreiras

et al. 2009

Blood Pressure Monitoring

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“…Barrios et al [26] noted that the absence of a decrease in HR during the resting period is independently related to mortality from any cause. In a recent metaanalysis, Bangalore and Messerli et al [4,27] found that in contrast to patients with myocardial infarction and heart failure, a beta-blocker-associated reduction in HR increased the risk of cardiovascular events and death among hypertensive patients.…”

Section: Discussionmentioning

confidence: 99%

Office and 24-hour heart rate and target organ damage in hypertensive patients

García-García

Gómez‐Marcos

Patino-Alonso

et al. 2012

BMC Cardiovasc Disord

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BackgroundWe investigated the association between heart rate and its variability with the parameters that assess vascular, renal and cardiac target organ damage.MethodsA cross-sectional study was performed including a consecutive sample of 360 hypertensive patients without heart rate lowering drugs (aged 56 ± 11 years, 64.2% male). Heart rate (HR) and its standard deviation (HRV) in clinical and 24-hour ambulatory monitoring were evaluated. Renal damage was assessed by glomerular filtration rate and albumin/creatinine ratio; vascular damage by carotid intima-media thickness and ankle/brachial index; and cardiac damage by the Cornell voltage-duration product and left ventricular mass index.ResultsThere was a positive correlation between ambulatory, but not clinical, heart rate and its standard deviation with glomerular filtration rate, and a negative correlation with carotid intima-media thickness, and night/day ratio of systolic and diastolic blood pressure. There was no correlation with albumin/creatinine ratio, ankle/brachial index, Cornell voltage-duration product or left ventricular mass index. In the multiple linear regression analysis, after adjusting for age, the association of glomerular filtration rate and intima-media thickness with ambulatory heart rate and its standard deviation was lost. According to the logistic regression analysis, the predictors of any target organ damage were age (OR = 1.034 and 1.033) and night/day systolic blood pressure ratio (OR = 1.425 and 1.512). Neither 24 HR nor 24 HRV reached statistical significance.ConclusionsHigh ambulatory heart rate and its variability, but not clinical HR, are associated with decreased carotid intima-media thickness and a higher glomerular filtration rate, although this is lost after adjusting for age.Trial RegistrationClinicalTrials.gov: NCT01325064

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“…Previous studies have shown that heart rate is a predictor of coronary events and cardiovascular mortality in various populations including general population and patients with hypertension, coronary disease or heart failure [1,2]. One of the proposed pathophysiological mechanisms for this finding is the detrimental effect of high heart rate on the progression of coronary atherosclerosis [1].…”

mentioning

confidence: 99%

“…One of the enzymes involved in ROS generation is xanthine dehydrogenase, which during reperfusion acts in reverse as xanthine oxidase (free radical-generating enzyme), as a result of the sudden higher availability of oxygen [2]. Allopurinol, alternatively to several myocardial antioxidants which reduce the amount of free radicals after their generation [3], acts as a xanthine oxidase inhibitor.…”

mentioning

confidence: 99%