High hepatitis E virus antibody positive rates in dogs and humans exposed to dogs in the south‐west of China

Zeng, Meng; Gao, Hui; Yan, Xiaohui; Qu, W. J.; Sun, Yansong; Fu, Guiming; Yan, Ye

doi:10.1111/zph.12377

Cited by 21 publications

(17 citation statements)

References 24 publications

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“…In Vietnam, animals captured at bus stations and hospitals have tested positive for rat HEV 48 . These findings are supported by serological evidence from domestic animals and rodents in other studies 45,49,50 .…”

Section: Fernandes Et Al (2019)supporting

confidence: 83%

Synanthropic rodents as virus reservoirs and transmitters

Gravinatti

Barbosa

Soares

et al. 2020

Rev. Soc. Bras. Med. Trop.

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This review focuses on reports of hepatitis E virus, hantavirus, rotavirus, coronavirus, and arenavirus in synanthropic rodents (Rattus rattus, Rattus norvegicus, and Mus musculus) within urban environments. Despite their potential impact on human health, relatively few studies have addressed the monitoring of these viruses in rodents. Comprehensive control and preventive activities should include actions such as the elimination or reduction of rat and mouse populations, sanitary education, reduction of shelters for the animals, and restriction of the access of rodents to residences, water, and food supplies.

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Section: Fernandes Et Al (2019)supporting

confidence: 83%

Synanthropic rodents as virus reservoirs and transmitters

Gravinatti

Barbosa

Soares

et al. 2020

Rev. Soc. Bras. Med. Trop.

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“…To investigate the prevalence of HEV in domestic pets in the Netherlands, we have collected serum samples from 162 dogs, we found that 18.52% (30/162) dogs were positive for anti-HEV antibodies in serum. Literature data on the seroprevalence of HEV antibodies in dogs ranges from 0.8% in UK [11], 28.2% in South Korea [7], 13.54 to 36.55% in different regions of China [6,[12][13][14], and 56.6% in Germany [15]. Genomic HEV RNA was not detectable in these serum samples by qRT-PCR.…”

Section: Resultsmentioning

confidence: 83%

“…Both domesticated and wild animals have been recognized as potential reservoirs [2][3][4]. Indeed, evidence has indicated that companion animals including dogs and cats might be accidental hosts for HEV and might constitute a source for HEV transmission to human [5,6]. A very recent study in South Korea has reported the seroprevalence of HEV in pet dogs and pet veterinarians of 28.2 and 5.0%, respectively [7].…”

Section: Introductionmentioning

confidence: 99%

Hepatitis E virus seroprevalence in pets in the Netherlands and the permissiveness of canine liver cells to the infection

Spee

et al. 2020

Ir Vet J

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Hepatitis E virus (HEV) as an emerging zoonotic pathogen causes a major public health issue. Transmission from domestic, wildlife and zoo animals to human has been widely reported. Whether pets also serve as reservoirs remains an intriguing question. In this study, we found the sero-positive rates of HEV-specific antibodies in pet dogs, cats and horses of 18.52% (30/162), 14.89% (7/47) and 18.18% (4/22) in the Netherlands. Although HEV viral RNA was not detected in these animals, we have demonstrated that dog liver cells are susceptible to HEV infection in vitro. These results call more attention to address the potential role of pets in the zoonotic transmission of HEV.

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“…Firstly, we may have missed evidence for virus circulation due to the limited size of the cattle cohort. Moreover, besides cattle, other susceptible animals, such as other ruminant species (Geng et al, ; Vitral et al, ; Zeng et al, ; Zhang et al, ) may be hosts of zoonotic HEV in rural Lao PDR. Indeed, even in our small cohorts of goat and buffaloes, few seropositives were found, suggesting a role also of other ruminants in HEV epidemiology.…”

Section: Discussionmentioning

confidence: 99%

Evidence of increased Hepatitis E virus exposure in Lao villagers with contact to ruminants

Tritz

Khounvisith²,

Pommasichan

et al. 2018

Zoonoses and Public Health

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Although pigs are the main reservoir, ruminants have also been shown to be susceptible to hepatitis E virus (HEV). We investigated zoonotic transmission of HEV in rural settings of Lao People's Democratic Republic (Lao PDR) where humans are in close contacts with ruminants and where pigs are rare. Villagers with (n = 171, risk group) and without (n = 155, control group) cattle were recruited in seven villages in Vientiane Capital. Owners of pigs were excluded. Blood, as well as information on socio-demographics, animal contact, dietary habits and awareness of zoonoses were collected to assess risk factors. Blood and rectal swabs were collected from cattle (n = 173) and other ruminants (27 goat, 5 buffaloes) to measure anti-HEV antibody and virus prevalence. A similar anti-HEV antibody seroprevalence was found in cattle (6.8%) and other ruminants (8%). HEV RNA was detected in none of the animal rectal swabs and human sera. Anti-HEV IgG seroprevalence was higher in cattle farmers than in the control group (59.1% vs. 43.9%, p = 0.008) and increased significantly with age. Other risk factors included male gender, close contact with cattle and consumption of undercooked meat. We find that HEV is highly endemic in rural Laos and provide first evidence that HEV circulates in free-roaming ruminants with open access to village water sources. Despite some awareness about hygiene, villagers are likely constantly exposed to zoonotic diseases by dietary and lifestyle habits. Cattle farmers had a higher risk of HEV infection than other villagers. Our study highlights the need to raise the awareness of the rural population about water- and food-borne pathogens, and about the role of cattle as a possible source of infection. The knowledge gained on local risk factors and husbandry conditions should guide future awareness raising campaigns and promote appropriate hygienic measures including handwashing and the consumption of safe food and water.

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High hepatitis E virus antibody positive rates in dogs and humans exposed to dogs in the south‐west of China

Cited by 21 publications

References 24 publications

Synanthropic rodents as virus reservoirs and transmitters

Synanthropic rodents as virus reservoirs and transmitters

Hepatitis E virus seroprevalence in pets in the Netherlands and the permissiveness of canine liver cells to the infection

Evidence of increased Hepatitis E virus exposure in Lao villagers with contact to ruminants

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