High humidity electrospinning of porous fibers for tuning the release of drug delivery systems

Ramos, Celia A Caveda; Lanno, Georg-Marten; Laidmäe, Ivo; Meos, Andres; Härmas, Riinu; Kogermann, Karin

doi:10.1080/00914037.2020.1765361

Cited by 23 publications

(32 citation statements)

References 58 publications

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“…JFP was extracted from the Ficus awkeotsang Makino achenes with slight modifications [ 24 ]. Briefly, 100 mL of 0.1 M EDTA aqueous solution was freshly prepared and adjusted to pH 8 using a 4M NaOH solution.…”

Section: Methodsmentioning

confidence: 99%

“…Recent studies demonstrated that the electrospinning technique has been widely employed in health care systems including drug delivery, diagnostics, theranostics, tissue engineering, and wound healing [ 19 , 20 , 21 , 22 , 23 , 24 ]. The multilayer electrospun membrane-based personalized reusable face mask has also been developed with photothermal application to disinfect the virus particles [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

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Fast Dissolving Electrospun Nanofibers Fabricated from Jelly Fig Polysaccharide/Pullulan for Drug Delivery Applications

et al. 2021

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The fast-dissolving drug delivery systems (FDDDSs) are developed as nanofibers using food-grade water-soluble hydrophilic biopolymers that can disintegrate fast in the oral cavity and deliver drugs. Jelly fig polysaccharide (JFP) and pullulan were blended to prepare fast-dissolving nanofiber by electrospinning. The continuous and uniform nanofibers were produced from the solution of 1% (w/w) JFP, 12% (w/w) pullulan, and 1 wt% Triton X-305. The SEM images confirmed that the prepared nanofibers exhibited uniform morphology with an average diameter of 144 ± 19 nm. The inclusion of JFP in pullulan was confirmed by TGA and FTIR studies. XRD analysis revealed that the increased crystallinity of JFP/pullulan nanofiber was observed due to the formation of intermolecular hydrogen bonds. The tensile strength and water vapor permeability of the JFP/pullulan nanofiber membrane were also enhanced considerably compared to pullulan nanofiber. The JFP/pullulan nanofibers loaded with hydrophobic model drugs like ampicillin and dexamethasone were rapidly dissolved in water within 60 s and release the encapsulants dispersive into the surrounding. The antibacterial activity, fast disintegration properties of the JFP/pullulan nanofiber were also confirmed by the zone of inhibition and UV spectrum studies. Hence, JFP/pullulan nanofibers could be a promising carrier to encapsulate hydrophobic drugs for fast-dissolving/disintegrating delivery applications.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fast Dissolving Electrospun Nanofibers Fabricated from Jelly Fig Polysaccharide/Pullulan for Drug Delivery Applications

et al. 2021

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“…Wang and his team reported that the bioactive drugs were loaded into the bilayer membrane and that they can release nanofibrous scaffolds separately without loss of functionality and structural integrity. [397,398] Rahmati et al reported the tissue engineering application based on the electrospun nanofibers Reproduced with permission. [397] Copyright 2020, Taylor & Francis Group, LLC., (III) a) PCL/ CP electrospun fibers b) gentamicin-loaded collagen/PCL nanofibers (GCP) for the tissue engineering application.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

“…[397,398] Rahmati et al reported the tissue engineering application based on the electrospun nanofibers Reproduced with permission. [397] Copyright 2020, Taylor & Francis Group, LLC., (III) a) PCL/ CP electrospun fibers b) gentamicin-loaded collagen/PCL nanofibers (GCP) for the tissue engineering application. Reproduced with permission under the CC-BY 4.0 license.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Electrospun Nanofibers: Materials, Synthesis Parameters, and Their Role in Sensing Applications

Kailasa

Reddy

Maurya

et al. 2021

Macro Materials & Eng

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Since the last decade, electrospinning is garnering more attention in the scientific research community, industries, applications like sensing (glucose, H 2 O 2 , dopamine, ascorbic acid, uric acid, neurotransmitter, etc.), biomedical applications (wound dressing, wound healing, skin, nerve, bone tissue engineering, and drug delivery systems), water treatment, energy harvesting, and storage applications. This review paper provides a brief overview of the electrospinning method, history of the electrospinning, factors affecting the electrospun nanofibers, and their morphology with different materials and composites (metals, metal oxides, 2D material, polymers and copolymers, carbon-based materials, etc.) used in the electrospinning technique with optical spinning parameters. Moreover, this paper deliberates the application of electrospun nanofibers and fibrous mats for sensing (electrochemical, optical, fluorescence, colorimetric, mechanical, photoelectric, mass sensitive change, resistive, ultrasensitive, etc.) in most illustrative representations. In the end, the challenges, opportunities of the electrospun nanofibers, and new direction for future progress are also discussed.

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“…The porosity of the nanofibrous scaffold and the porosity of a single nanofiber affect the drug release effects [ 20 ]. High surface areas and porosity are the main advantages of nanofibers as drug delivery systems, which are conducive to cell anchoring and modify the wetting process, adsorption/absorption, and release behavior of drugs [ 2 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Porous Coaxial Drug-Carrying Nanofibers for Sustained Drug-Releasing Applications

Chen

et al. 2021

Nanomaterials

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The phenomenon of drug burst release is the main problem in the field of drug delivery systems, as it means that a good therapeutic effect cannot be acheived. Nanofibers developed by electrospinning technology have large specific surface areas, high porosity, and easily controlled morphology. They are being considered as potential carriers for sustained drug release. In this paper, we obtained polycaprolactone (PCL)/polylactic acid (PLA) core-shell porous drug-carrying nanofibers by using coaxial electrospinning technology and the nonsolvent-induced phase separation method. Roxithromycin (ROX), a kind of antibacterial agent, was encapsulated in the core layer. The morphology, composition, and thermal properties of the resultant nanofibers were characterized by scanning electron microscopy (SEM), attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy, differential scanning calorimetry (DSC) and thermogravimetry analysis (TGA). Besides this, the in vitro drug release profile was investigated; it showed that the release rate of the prepared coaxial porous nanofibers with two different pore sizes was 30.10 ± 3.51% and 35.04 ± 1.98% in the first 30 min, and became 92.66 ± 3.13% and 88.94 ± 1.58% after 14 days. Compared with the coaxial nonporous nanofibers and nanofibers prepared by uniaxial electrospinning with or without pores, the prepared coaxial porous nanofibers revealed that the burst release was mitigated and the dissolution rate of the hydrophobic drugs was increased. The further antimicrobial activity demonstrated that the inhibition zone diameter of the coaxial nanofibers with two different pore sizes was 1.70 ± 0.10 cm and 1.73 ± 0.23 cm, exhibiting a good antibacterial effect against Staphylococcus aureus. Therefore, the prepared nanofibers with the coaxial porous structures could serve as promising drug delivery systems.

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High humidity electrospinning of porous fibers for tuning the release of drug delivery systems

Cited by 23 publications

References 58 publications

Fast Dissolving Electrospun Nanofibers Fabricated from Jelly Fig Polysaccharide/Pullulan for Drug Delivery Applications

Fast Dissolving Electrospun Nanofibers Fabricated from Jelly Fig Polysaccharide/Pullulan for Drug Delivery Applications

Electrospun Nanofibers: Materials, Synthesis Parameters, and Their Role in Sensing Applications

Antibacterial Porous Coaxial Drug-Carrying Nanofibers for Sustained Drug-Releasing Applications

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