High hydrostatic pressure enhances the anti-proliferative properties of lotus bee pollen on the human prostate cancer PC-3 cells via increased metabolites

Tuoheti, Tuhanguli; Rasheed, Hafiz Abdul; Li, Meng; Dong, Ming

doi:10.1016/j.jep.2020.113057

Cited by 12 publications

(6 citation statements)

References 33 publications

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“…The bioactive compounds of bee pollen are strongly dependent on the pollen’s botanical origin and geographical conditions (Muñoz et al ., 2020). The consumption of bee pollen has increased worldwide due to its inclusion in food as an health ingredient, taking advantage of its numerous functional properties, including anticancer, antiobesity, antimicrobial, anti‐inflammatory, antioxidant, and antihyperpigmentation (Maruyama et al ., 2010; Cheng et al ., 2019; Kaškonienė et al ., 2020; Tuoheti et al ., 2020). Moreover, bee pollen can regulate hypolipidaemic activity by decreasing the content of total lipids and cholesterol (Denisow & Denisow‐Pietrzyk, 2016), and improving liver function (Uzbekova et al ., 2003).…”

Section: Introductionmentioning

confidence: 99%

Performance of green and conventional techniques for the optimal extraction of bioactive compounds in bee pollen

Aylanç

Ertosun

Russo‐Almeida

et al. 2022

Int J of Food Sci Tech

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The exploitation of phenolic compounds in different fields has motivated researchers to explore ecofriendly and efficient extraction techniques. This study aimed to comparatively reveal that green extraction techniques (microwave-and ultrasound-assisted) are alternative to conventional extraction (maceration and magnetic stirring) with positive impact on the phenolic content, antioxidant activity, and bioactive profile of bee pollen extracts. The highest total phenolic and flavonoid content was reached using the microwave-assisted technique (MAE) with equivalent values of 28 and 8 mg g −1 , with magnetic stirring and maceration showing a lower value. The composition profile of the extracts revealed the presence of twenty-six bioactive compounds, including thirteen phenolics and thirteen phenylamides. Although the extraction technique had little impact on the chemical diversity, the amount of bioactive compounds raised significantly with the use of the green extraction techniques, with gains between 40% and 60% for phenolics and up to 200% for phenylamides. The radical scavenging activity and the reducing power of the extracts confirmed that bee pollens are potent antioxidant source, with the most bioactive extracts corresponding to green extraction techniques. Consequently, all findings recommend the use of MAE as the technique most effective for the extraction of bioactive compounds from naturally encapsulated structures such as bee pollen.

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Section: Introductionmentioning

confidence: 99%

Performance of green and conventional techniques for the optimal extraction of bioactive compounds in bee pollen

Aylanç

Ertosun

Russo‐Almeida

et al. 2022

Int J of Food Sci Tech

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“…18), and C-GS (no. 25; Table 1), including 36 protopanaxadiol (PPD)-type, 46 protopanaxatriol (PPT)-type, 10 oleanolic acid (OA)-type, and 107 other types of saponins (see Figure 2, Table S1), by comparing MS data with our previous research [12] and other published data [3,4,11,[13][14][15][16][17][18][19][20][21].…”

Section: Identification Of Saponins In Wild Ginseng Ginseng Under Forest and Cultivated Ginseng With Hplc-it-tof-ms Nmentioning

confidence: 99%

“…Sixteen potential new compounds were tentatively identified from ginseng via HPLC-IT-TOF-MS n by comparing MS n data to previous publications [3,4,[11][12][13][14][15][16][17][18][19][20][21] O, the side chain at C20 of the aglycone, Diff: 22.13 ppm). The neutral loss of 100 Da was the characteristic neutral loss of aglycone B4-a in Figure 2C [3].…”

Section: Potential New Compounds Found In Wild Ginseng Ginseng Under Forest and Cultivated Ginseng Via Hplc-it-tof-ms Nmentioning

confidence: 99%

177 Saponins, Including 11 New Compounds in Wild Ginseng Tentatively Identified via HPLC-IT-TOF-MSn, and Differences among Wild Ginseng, Ginseng under Forest, and Cultivated Ginseng

Wang

Zhao

et al. 2021

Molecules

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Wild ginseng (W-GS), ginseng under forest (F-GS, planted in mountain forest and growing in natural environment), and cultivated ginseng (C-GS) were compared via HPLC-DAD and HPLC-IT-TOF-MSn. A total of 199 saponins, including 16 potential new compounds, were tentatively identified from 100 mg W-GS (177 saponins in W-GS with 11 new compounds), F-GS (56 saponins with 1 new compound), and C-GS (60 saponins with 6 new compounds). There were 21 saponins detected from all the W-GS, F-GS, and C-GS. Fifty saponins were only detected from W-GS, including 23 saponins found in ginseng for the first time. Contents of ginsenosides Re (12.36–13.91 mg/g), Rh1 (7.46–7.65 mg/g), Rd (12.94–12.98 mg/g), and the total contents (50.52–55.51 mg/g) of Rg1, Re, Rf, Rb1, Rg2, Rh1, and Rd in W-GS were remarkably higher than those in F-GS (Re 1.22–3.50 mg/g, Rh1 0.15–1.49 mg/g, Rd 0.19–1.49 mg/g, total 5.69–18.74 mg/g), and C-GS (Re 0.30–3.45 mg/g, Rh1 0.05–3.42 mg/g, Rd 0.17–1.68 mg/g, total 2.99–19.55 mg/g). Contents of Re and Rf were significantly higher in F-GS than those in C-GS (p < 0.05). Using the contents of Re, Rf, or Rb1, approximately a half number of cultivated ginseng samples could be identified from ginseng under forest. Contents of Rg1, Re, Rg2, Rh1, as well as the total contents of the seven ginsenosides were highest in ginseng older than 15 years, middle–high in ginseng between 10 to 15 years old, and lowest in ginseng younger than 10 years. Contents of Rg1, Re, Rf, Rb1, Rg2, and the total of seven ginsenosides were significantly related to the growing ages of ginseng (p < 0.10). Similarities of chromatographic fingerprints to W-GS were significantly higher (p < 0.05) for F-GS (median: 0.824) than C-GS (median: 0.745). A characteristic peak pattern in fingerprint was also discovered for distinguishing three types of ginseng. Conclusively, wild ginseng was remarkably superior to ginseng under forest and cultivated ginseng, with ginseng under forest slightly closer to wild ginseng than cultivated ginseng. The differences among wild ginseng, ginseng under forest, and cultivated ginseng in saponin compositions and contents of ginsenosides were mainly attributed to their growing ages.

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“…The anticancer impact of bee pollen administration is explained by the observed underlying mechanism, such as the stimulation of apoptosis, the inhibition of cell proliferation in multiple cell lines, and the reduction of tumor growth [ 26 , 27 , 28 ]. Lotus ( Nelumbo nucifera) bee pollen can induce apoptosis and inhibit the proliferation of human prostate cancer PC-3 cells ( Figure 1 ) [ 29 ].…”

Section: Clinical Trialsmentioning

confidence: 99%

Bee Pollen: Clinical Trials and Patent Applications

et al. 2022

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Bee pollen is a natural cocktail of floral nectar, flower pollen, enzymes, and salivary secretions produced by honeybees. Bee pollen is one of the bee products most enriched in proteins, polysaccharides, polyphenols, lipids, minerals, and vitamins. It has a significant health and medicinal impact and provides protection against many diseases, including diabetes, cancer, infectious, and cardiovascular. Bee pollen is commonly promoted as a cost-effective functional food. In particular, bee pollen has been applied in clinical trials for allergies and prostate illnesses, with a few investigations on cancer and skin problems. However, it is involved in several patents and health recipes to combat chronic health problems. This review aimed to highlight the clinical trials and patents involving bee pollen for different cases and to present the role of bee pollen as a supplementary food and a potential product in cosmetic applications.

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High hydrostatic pressure enhances the anti-proliferative properties of lotus bee pollen on the human prostate cancer PC-3 cells via increased metabolites

Cited by 12 publications

References 33 publications

Performance of green and conventional techniques for the optimal extraction of bioactive compounds in bee pollen

Performance of green and conventional techniques for the optimal extraction of bioactive compounds in bee pollen

177 Saponins, Including 11 New Compounds in Wild Ginseng Tentatively Identified via HPLC-IT-TOF-MSn, and Differences among Wild Ginseng, Ginseng under Forest, and Cultivated Ginseng

Bee Pollen: Clinical Trials and Patent Applications

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High hydrostatic pressure enhances the anti-proliferative properties of lotus bee pollen on the human prostate cancer PC-3 cells via increased metabolites

Cited by 12 publications

References 33 publications

Performance of green and conventional techniques for the optimal extraction of bioactive compounds in bee pollen

Performance of green and conventional techniques for the optimal extraction of bioactive compounds in bee pollen

177 Saponins, Including 11 New Compounds in Wild Ginseng Tentatively Identified via HPLC-IT-TOF-MSn, and Differences among Wild Ginseng, Ginseng under Forest, and Cultivated Ginseng

Bee Pollen: Clinical Trials and Patent Applications

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High hydrostatic pressure enhances the anti-proliferative properties of lotus bee pollen on the human prostate cancer PC-3 cells via increased metabolites