High hydrostatic pressure in cancer immunotherapy and biomedicine

Adkins, Irena; Hradilova, Nada; Palata, Ondřej; Sadílková, Lenka; Palová-Jelínková, Lenka; Špíšek, Radek

doi:10.1016/j.biotechadv.2018.01.015

Cited by 24 publications

(25 citation statements)

References 48 publications

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“…Hydrostatic pressure (HP) is an important environmental parameter, while (high hydrostatic pressure) high hydrostatic pressure (HHP) has effects on biomolecules, cellular processes and viability, which are the basis of the antitumour effect of HHP. According to the pressure, HHP has been divided into ‘physiological HHP’ (<100 MPa) and ‘non‐physiological HHP’ (>100 MPa) . Fucikova et al identified the potential of HHP to influence the type of cell death that occurs in human cancer cell lines (leukaemia, ovarian cancer and prostate cancer), as well as in primary lymphocytic leukaemia cells.…”

Section: Emerging Methods Of Icd Inductionmentioning

confidence: 99%

“…According to the pressure, HHP has been divided into 'physiological HHP' (<100 MPa) and 'non-physiological HHP' (>100 MPa). 81 leading the DCs to acquire an immunostimulatory phenotype that activates antigen presentation and induces the activation of tumour antigen-specific CD8 + and CD4 + T cells. 53 Further investigations have shown that, the induction of ICD via HHP is mediated by ER stress;…”

Section: High Hydrostatic Pressurementioning

confidence: 99%

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Immunogenic cell death in cancer therapy: Present and emerging inducers

Zhou

Wang

Chen

et al. 2019

J Cellular Molecular Medi

545

358

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In the tumour microenvironment (TME), immunogenic cell death (ICD) plays a major role in stimulating the dysfunctional antitumour immune system. Chronic exposure of damage‐associated molecular patterns (DAMPs) attracts receptors and ligands on dendritic cells (DCs) and activates immature DCs to transition to a mature phenotype, which promotes the processing of phagocytic cargo in DCs and accelerates the engulfment of antigenic components by DCs. Consequently, via antigen presentation, DCs stimulate specific T cell responses that kill more cancer cells. The induction of ICD eventually results in long‐lasting protective antitumour immunity. Through the exploration of ICD inducers, recent studies have shown that there are many novel modalities with the ability to induce immunogenic cancer cell death. In this review, we mainly discussed and summarized the emerging methods for inducing immunogenic cancer cell death. Concepts and molecular mechanisms relevant to antitumour effects of ICD are also briefly discussed.

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Section: Emerging Methods Of Icd Inductionmentioning

confidence: 99%

Section: High Hydrostatic Pressurementioning

confidence: 99%

Immunogenic cell death in cancer therapy: Present and emerging inducers

Zhou

Wang

Chen

et al. 2019

J Cellular Molecular Medi

545

358

View full text Add to dashboard Cite

show abstract

“…In urothelial carcinoma cells, 102–1020 cmH 2 O HP promotes apoptosis with the elevation of the expression of Fas ligand, toll-like receptor 6 and connective tissue growth factor in the presence of mitomycin C [109,110]. In addition, extremely high HP more than 1 million cmH 2 O induces immunogenic cell death in tumor cells and is used for the method in cancer immunotherapy [111,112]. In contrast, small degree of the HP gradient from a basal side has been known to have carcinogenic effects on the epithelia.…”

Section: Effects Of Hp On the Epithelia And Endotheliamentioning

confidence: 99%

Regulation of Epithelial Cell Functions by the Osmolality and Hydrostatic Pressure Gradients: A Possible Role of the Tight Junction as a Sensor

Tokuda

2019

IJMS

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Epithelia act as a barrier to the external environment. The extracellular environment constantly changes, and the epithelia are required to regulate their function in accordance with the changes in the environment. It has been reported that a difference of the environment between the apical and basal sides of epithelia such as osmolality and hydrostatic pressure affects various epithelial functions including transepithelial transport, cytoskeleton, and cell proliferation. In this paper, we review the regulation of epithelial functions by the gradients of osmolality and hydrostatic pressure. We also examine the significance of this regulation in pathological conditions especially focusing on the role of the hydrostatic pressure gradient in the pathogenesis of carcinomas. Furthermore, we discuss the mechanism by which epithelia sense the osmotic and hydrostatic pressure gradients and the possible role of the tight junction as a sensor of the extracellular environment to regulate epithelial functions.

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“…Besides, pressure may be used for diverse biotechnological and biopharmaceutical applications, for example to explore new therapies [122,123] and conserve vaccines [123], improve cryopreservation [125] or for orthopaedics' surgery [126]. [75].…”

Section: Pressure Biotechnological Applicationsmentioning

confidence: 99%

High-pressure adaptation of extremophiles and biotechnological applications

Salvador-Castell

Oger

Peters

2020

Physiological and Biotechnological Aspects of Extremophiles

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During the last decades, high pressure has been an important physical parameter not only to study biomolecules, but also for its biotechnological applications. High pressure affects organism's ability to survive by altering most of cell's macromolecules. These effects can be used, for example, to inactivate microorganisms, enhance enzymatic reactions or to modulate cell activities. Moreover, some organisms are capable to growth under high pressures thanks to their adaptation at all cellular levels. Such adaptation confers a wide range of potentially interesting macromolecules still to be discovered. In this chapter, we firstly present the different effects of pressure on cells and the diverse strategies used to cope against this harsh environment. Secondly, we explored the pressure biotechnological applications on pressure-sensitive and adaptedpressure organisms.

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High hydrostatic pressure in cancer immunotherapy and biomedicine

Cited by 24 publications

References 48 publications

Immunogenic cell death in cancer therapy: Present and emerging inducers

Immunogenic cell death in cancer therapy: Present and emerging inducers

Regulation of Epithelial Cell Functions by the Osmolality and Hydrostatic Pressure Gradients: A Possible Role of the Tight Junction as a Sensor

High-pressure adaptation of extremophiles and biotechnological applications

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