High IGF2 expression is associated with poor clinical outcome in human ovarian cancer

Dong, Yan; Li, Jianjun; Han, Fangfang; Chen, Hongqiang; Zhao, Xingxu; Qin, Qin; Shi, R H; Liu, Jinyi

doi:10.3892/or.2015.4048

Cited by 33 publications

(24 citation statements)

References 36 publications

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“…2A-c), PLAG1 was overexpressed in Oc tissues. The expression of IGF2 was abundant in Oc, as previously described (33,34). Of importance, PLAG1, as a transcriptional activator of IGF2, regulates expression of IGF2 (35).…”

Section: Plag1 and Igf2 Gene Expression Is Increased In Oc Degs Assosupporting

confidence: 63%

PLAG1 silencing promotes cell chemosensitivity in ovarian cancer via the IGF2 signaling pathway

Huang

Feng

2020

Int J Mol Med

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Ovarian cancer (Oc) is one of the most lethal gynecological diseases. Novel prognostic biomarkers and therapeutic targets for Oc are urgently required. The aim of this study was to investigate the mechanisms that govern how pleomorphic adenoma gene 1 (PLAG1) influences the biological processes and chemosensitivity of Oc cells via the insulin-like growth factor-2 (IGF2) signaling pathway. differentially expressed genes in Oc were selected based on bioinformatics data. Oc and adjacent tissue specimen were collected, followed by the determination of the expression of PLAG1 and IGF2 signaling pathway-associated genes. The regulatory mechanisms of PLAG1 in Oc cells were analyzed following treatment with pcdNA or small interfering RNA (siRNA), and included the assessment of cell proliferation, migration, invasion and cisplatin resistance. PLAG1 was identified as an upregulated gene in OC. OC tissues exhibited increased expression of PLAG1 and IGF2 compared with the controls. Moreover, PLAG1 was observed to positively regulate the IGF2 signaling pathway. The siRNA-mediated silencing of PLAG1 resulted in decreased expression of IGF2, IGF1 receptor and insulin receptor substrate 1, as well as inhibited proliferation, migration, invasion and cisplatin resistance of Oc cells. Furthermore, the effect of PLAG1 was dependent on IGF2. PLAG1 may therefore be considered as a possible target for the treatment of Oc.

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Section: Plag1 and Igf2 Gene Expression Is Increased In Oc Degs Assosupporting

confidence: 63%

PLAG1 silencing promotes cell chemosensitivity in ovarian cancer via the IGF2 signaling pathway

Huang

Feng

2020

Int J Mol Med

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“…In relation to inflammatory markers, DII has been shown to be associated with CRP (9), IL-6 (11), TNF-a (11) and homocysteine (10). A possible common mechanism could be the effect of pro-inflammatory diet on insulin-like growth factor (IGF), which has been shown to be a promoter of carcinogenesis (40, 41) by exerting its well-established mitotic, antiapoptotic and proangiogenic effects (42). Experimental studies have shown that IGF-I protein, receptor and mRNA are expressed in ovarian cancer cells and tissues and that they are associated with progression of ovarian cancer (43).…”

Section: Discussionmentioning

confidence: 99%

Dietary inflammatory index and ovarian cancer risk in a large Italian case–control study

Shivappa

Hébert

Rosato

et al. 2016

Cancer Causes Control

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Background While inflammation has been shown to play an important etiologic role in ovarian carcinogenesis, little is known about the association between inflammatory properties of diet and ovarian cancer risk. Methods We explored the association between the dietary inflammatory index (DII) and ovarian cancer risk in a multicentric Italian case-control study conducted between 1992 and 1999. Cases were 1031 women with incident, histologically confirmed ovarian cancer from 4 areas in Italy. Controls were 2,411 women admitted to the same network of hospitals as the cases for acute, non-malignant and non-gynecological conditions, unrelated to hormonal or digestive-tract diseases or committed to long-term modifications of diet. DII scores were computed based on 31 nutrients and food items assessed using a reproducible and validated 78-item food frequency questionnaire. Odds ratios (ORs) were estimated through logistic regression models adjusting for age, total energy intake and other recognised confounding factors. Results Subjects in the highest quartile of DII scores (i.e., with the most pro-inflammatory diets) had a higher risk of ovarian cancer compared to subjects in the lowest quartile (i.e., with an anti-inflammatory diet) (ORQuartile4vs1= 1.47, 95% confidence interval, CI, 1.07, 2.01; p-trend=0.009). When analyses were carried out using continuous DII, a significant positive association with ovarian cancer was observed, the OR for one-unit increment in DII score (corresponding to approximately 8% of its range in the current study, +6.0 to −6.20) was 1.08 (95% CI=1.02, 1.14). Conclusion A pro-inflammatory diet as indicated by higher DII scores is associated with increased ovarian cancer risk.

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“…The results indicated that 9 of them were significantly associated with survival and could be considered as potential prognostic markers for GC. Among the 9 lncRNAs, high IGF2-AS expression has been reported to be associated with poor clinical outcomes in ovarian cancer (52), and ADAMTS9-AS2 has also been identified as a poor prognostic biomarker of colorectal cancer (53) and glioma (54) with DNA methyltransferase-1. However, the roles of remaining 7 lncRNAs (ABCA9-AS1, ADAMTS9-AS1, AL139002.1, AL391152.1, C15orf54, FRMD6-AS2 and VCAN-AS1) have not yet been reported.…”

Section: Discussionmentioning

confidence: 99%

TCGA dataset‑based construction and integrated analysis of aberrantly expressed long non‑coding RNA mediated competing endogenous RNA network in gastric cancer

Zhang

et al. 2018

Oncol Rep

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The aberrant expression of long non-coding RNAs (lncRNAs) has been confirmed to play a pivotal role in tumor initiation and development. LncRNAs can interact with microRNAs (miRNAs) as competing endogenous RNAs (ceRNAs) to regulate the expression of target genes in various cancers. In the present study, the authors investigated the functions of lncRNAs as ceRNAs in gastric cancer (GC) and their implications for the prognosis. The RNA sequencing profiles of 372 tumor samples and 32 adjacent non-tumor gastric samples were downloaded from The Cancer Genome Atlas (TCGA) database. The differential expression of RNAs was identified using the ʻedgeRʼ package in R language software. Survival analysis was estimated based on Kaplan-Meier curves. The Gene Ontology biological processes and the Kyoto Encyclopedia of Genes and Genomes pathways were analyzed for differentially expressed mRNAs. Finally, a total of 999 lncRNAs, 137 miRNAs and 1629 mRNAs were identified as differentially expressed (DE) in GC with log fold change (FC) thresholds >2 and adjusted P-values <0.01. A ceRNA network was constructed with 65 DElncRNAs, nine DEmiRNAs and 24 DEmRNAs. Of the 65 DElncRNAs in the ceRNA network, nine were identified to be significantly associated with overall survival (P<0.05). A total of four DElncRNAs from the ceRNA network were validated by reverse transcription-quantitative polymerase chain reaction and revealed to be associated with tumorigenesis and/or progression. In conclusion, the results of the present study provide information on the role of the ceRNA network in GC. These identified novel lncRNAs are potential candidate biomarkers and require further studies.

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High IGF2 expression is associated with poor clinical outcome in human ovarian cancer

Cited by 33 publications

References 36 publications

PLAG1 silencing promotes cell chemosensitivity in ovarian cancer via the IGF2 signaling pathway

PLAG1 silencing promotes cell chemosensitivity in ovarian cancer via the IGF2 signaling pathway

Dietary inflammatory index and ovarian cancer risk in a large Italian case–control study

TCGA dataset‑based construction and integrated analysis of aberrantly expressed long non‑coding RNA mediated competing endogenous RNA network in gastric cancer

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