High impulsive choice is accompanied by an increase in dopamine release in rat dorsolateral striatum

Moreno, Macarena; Azocar, Victor Hugo; Vergés, Álvaro

doi:10.1016/j.bbr.2021.113199

Cited by 11 publications

(4 citation statements)

References 72 publications

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“…Alternative tasks or outcome measures might be used in future experiments. For example, 1 recent study linked high levels of extracellular dopamine in DLS with high impulsivity in a delay-discounting task, 48 while another study linked a molecularly defined population of dopamine neurons that primarily projects to DLS (Aldh1a1+ dopamine neurons) to motor learning on the accelerating rotarod. 49 Future work should also examine temporal patterns.…”

Section: Articlementioning

confidence: 99%

Dopamine signaling in the dorsomedial striatum promotes compulsive behavior

et al. 2022

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Compulsive behavior is a defining feature of disorders such as substance use disorders. Current evidence suggests that corticostriatal circuits control the expression of established compulsions, but little is known about the mechanisms regulating the development of compulsions. We hypothesized that dopamine, a critical modulator of striatal synaptic plasticity, could control alterations in corticostriatal circuits leading to the development of compulsions (defined here as continued reward seeking in the face of punishment). We used dual-site fiber photometry to measure dopamine axon activity in the dorsomedial striatum (DMS) and the dorsolateral striatum (DLS) as compulsions emerged. Individual variability in the speed with which compulsions emerged was predicted by DMS dopamine axon activity. Amplifying this dopamine signal accelerated animals' transitions to compulsion, whereas inhibition delayed it. In contrast, amplifying DLS dopamine signaling had no effect on the emergence of compulsions. These results establish DMS dopamine signaling as a key controller of the development of compulsive reward seeking.

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Section: Articlementioning

confidence: 99%

Dopamine signaling in the dorsomedial striatum promotes compulsive behavior

et al. 2022

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“…DLS dopamine may also be involved in other tasks. For example, one recent study linked high levels of extracellular dopamine in the DLS with high impulsivity in a delay-discounting task (Moreno et al, 2021). Another study linked a molecularly-defined population of dopamine neurons that primarily projects to the DLS (Aldh1a1+ dopamine neurons) to motor learning on the accelerating rotarod (Wu et al, 2019).…”

Section: Unanswered Questionsmentioning

confidence: 99%

Dopamine Signaling in the Dorsomedial Striatum Promotes Compulsive Behavior

Jl¹,

Cv²,

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et al. 2020

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Habits and compulsions are two aspects of behavior that often develop in parallel and together lead to inflexible responding. Both habits and compulsions are hypothesized to be involved in psychiatric disorders such as drug addiction and obsessive-compulsive disorder (OCD), but they are distinct behaviors that may rely on different brain circuitries. We developed an experimental paradigm to track the development of both habits and compulsions in individual animals while recording neural activity. We performed fiber photometry measurements of dopamine axon activity while mice engaged in reinforcement learning on a random interval (RI60) schedule and found that the emergence of compulsion was predicted by the dopamine signal in the dorsomedial striatum (DMS). By amplifying this DMS dopamine signal throughout training using optogenetics, we accelerated animals' transitions to compulsion, irrespective of habit formation. These results establish DMS dopamine signaling as a key controller of compulsions.

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“…In the search for biological markers associated with addictive traits, low striatal D 2/3 receptor availability was linked to high impulsivity [ 60 , 61 , 62 ] and was predictive of high rates of intravenous cocaine self-administration [ 60 ]. Likewise, high DAT expression was found to be associated with impulsive choice [ 63 ], characterized by a marked shift of demand from the large and delayed toward the small and soon reward [ 64 ]. Indeed, intra-NAc DAT overexpressing rats showed increased impulsivity [ 64 ].…”

Section: Social Rank and The Mesolimbic Dopamine Systemmentioning

confidence: 99%

Is It Possible to Shift from Down to Top Rank? A Focus on the Mesolimbic Dopaminergic System and Cocaine Abuse

2021

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Impaired social behavior is a common feature of many psychiatric disorders, in particular with substance abuse disorders. Switching the preference of the substance-dependent individual toward social interaction activities remains one of the major challenges in drug dependence therapy. However, social interactions yield to the emergence of social ranking. In this review, we provide an overview of the studies that examined how social status can influence the dopaminergic mesolimbic system and how drug-seeking behavior is affected. Generally, social dominance is associated with an increase in dopamine D2/3 receptor binding in the striatum and a reduced behavioral response to drugs of abuse. However, it is not clear whether higher D2 receptor availability is a result of increased D2 receptor density and/or reduced dopamine release in the striatum. Here, we discuss the possibility of a potential shift from down to top rank via manipulation of the mesolimbic system. Identifying the neurobiology underlying a potential rank switch to a resilient phenotype is of particular interest in order to promote a positive coping behavior toward long-term abstinence from drugs of abuse and a protection against relapse to drugs. Such a shift may contribute to a more successful therapeutic approach to cocaine addiction.

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High impulsive choice is accompanied by an increase in dopamine release in rat dorsolateral striatum

Cited by 11 publications

References 72 publications

Dopamine signaling in the dorsomedial striatum promotes compulsive behavior

Dopamine signaling in the dorsomedial striatum promotes compulsive behavior

Dopamine Signaling in the Dorsomedial Striatum Promotes Compulsive Behavior

Is It Possible to Shift from Down to Top Rank? A Focus on the Mesolimbic Dopaminergic System and Cocaine Abuse

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