High incidence of acute myeloid leukemia in SJL/J mice after x-irradiation and corticosteroids

Resnitzky, P; Estrov, Zeev; Haran-Ghera, Nechama

doi:10.1016/0145-2126(85)90045-1

Cited by 45 publications

(30 citation statements)

References 27 publications

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“…The incidence increases with doses up to 3 Gy and the symptoms of the affected mice are similar to those found in human AML (Upton et al, 1958;Major, 1979;Mole et al, 1983;Resnitzky et al, 1985;Seki et al, 1991). The leukaemic cells usually carry a deletion of chromosome 2 (Hayata et al, 1983;Trakhtenbrot et al, 1988;Rithidech et al, 1993;Clark et al, 1996) and a mutation of the Sfpi1 gene on the retained homologue (Cook et al, 2004;Suraweera et al, 2005;Hirouchi et al, 2008).…”

mentioning

confidence: 70%

Implication of replicative stress-related stem cell ageing in radiation-induced murine leukaemia

Ban

Kai

2009

Br J Cancer

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BACKGROUND: The essential aetiology of radiation-induced acute myeloid leukaemia (AML) in mice is the downregulation of the transcription factor PU.1. The causative mutation of the PU.1-endocing Sfpi1 gene consists mostly of C:G to T:A transitions at a CpG site and is likely to be of spontaneous origin. To work out a mechanism underlying the association between radiation exposure and the AML induction, we have hypothesised that replicative stress after irradiation accelerates the ageing of haematopoietic stem cells (HSCs), and the ageing-related decline in DNA repair could affect the spontaneous mutation rates. METHODS: Mathematical model analysis was conducted to examine whether and to what extent the cell kinetics of HSCs can be modified after irradiation. The haematopoietic differentiation process is expressed as a mathematical model and the cell-kinetics parameters were estimated by fitting the simulation result to the assay data. RESULTS: The analysis revealed that HSCs cycle vigourously for more than a few months after irradiation. The estimated number of cell divisions per surviving HSC in 3 Gy-exposed mice reached as high as ten times that of the unexposed. INTERPRETATION: The mitotic load after 3 Gy irradiation seems to be heavy enough to accelerate the ageing of HSCs and the hypothesis reasonably explains the leukaemogenic process.

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confidence: 70%

Implication of replicative stress-related stem cell ageing in radiation-induced murine leukaemia

Ban

Kai

2009

Br J Cancer

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“…It has been known for years by the present investigators that four strains of mice developed an increased incidence of acute myelogenous leukemia after exposure to ionizing radiation (50)(51)(52)(53)(54). The RFM strain is less desirable because of expense and it has a high spontaneous incidence of acute myeloblastic and other leukemias.…”

Section: Discussionmentioning

confidence: 99%

Hematotoxicity and Carcinogenicity of Inhaled Benzene

Cronkite¹,

Drew²,

Inoue³

et al. 1989

Environmental Health Perspectives

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“…Leukemia was established in study mice as previously described (19–21). Polyclonal rat IgG antibody (negative control) was purchased from Sigma Aldrich (St Louis, MO).…”

Section: Methodsmentioning

confidence: 99%

In Vivo Localization of 90Y and 177Lu Radioimmunoconjugates Using Cerenkov Luminescence Imaging in a Disseminated Murine Leukemia Model

et al. 2014

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Cerenkov radiation generated by positron-emitting radionuclides can be exploited for a molecular imaging technique known as Cerenkov Luminescence Imaging (CLI). Data have been limited, however, on the use of medium-to-high energy β-emitting radionuclides of interest for cancer imaging and treatment. We assessed the use of CLI as an adjunct to determine localization of radioimmunoconjugates to hematolymphoid tissues. Radiolabeled 177Lu- or 90Y-anti-CD45 antibody (Ab; DOTA-30F11) was administered by tail vein injection to athymic mice bearing disseminated murine myeloid leukemia with CLI images acquired at times afterward. Gamma counting of individual organs showed preferential uptake in CD45+ tissues with significant retention of radiolabeled Ab in sites of leukemia (spleen and bone marrow). This result was confirmed in CLI images with 1.35 × 105 ± 2.2 × 104 p/sec/cm2/sr and 3.45 × 103 ± 7.0 × 102 p/sec/cm2/sr for 90Y-DOTA-30F11 and 177Lu-DOTA-30F11, respectively, compared to undetectable signal for both radionuclides using the non-binding control Ab. Results showed that CLI allows for in vivo visualization of localized β-emissions. Pixel intensity variability resulted from differences in absorbed doses of the associated energies of the β-emitting radionuclide. Overall, our findings offer a preclinical proof of concept for the use of CLI techniques in tandem with currently available clinical diagnostic tools.

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High incidence of acute myeloid leukemia in SJL/J mice after x-irradiation and corticosteroids

Cited by 45 publications

References 27 publications

Implication of replicative stress-related stem cell ageing in radiation-induced murine leukaemia

Implication of replicative stress-related stem cell ageing in radiation-induced murine leukaemia

Hematotoxicity and Carcinogenicity of Inhaled Benzene

In Vivo Localization of 90Y and 177Lu Radioimmunoconjugates Using Cerenkov Luminescence Imaging in a Disseminated Murine Leukemia Model

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