High Incidence of Acute Myositis with Type A Influenza Virus Infection in the Elderly.

Yoshino, Masatoshi; Suzuki, Satowa; Adachi, Keiko; Fukayama, Makiko; Igarashi, Takashi

doi:10.2169/internalmedicine.39.431

Cited by 27 publications

(19 citation statements)

References 6 publications

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“…There have been approximately 27 reported cases of rhabdomyolysis in the setting of influenza infection, although this likely represents a small fraction of the total cases as myositis and/or rhabdomyolysis have infrequently been reported prior to the 2009 A(H1N1) pandemic (Table ) . Among 18 patients in Mexico with influenza A(H1N1)pdm09 infection, 62% of patients had mild‐to‐moderate elevations of creatinine kinase (CK) .…”

Section: Resultsmentioning

confidence: 99%

The hidden burden of influenza: A review of the extra‐pulmonary complications of influenza infection

Sellers

Hagan

Hayden

et al. 2017

Influenza Resp Viruses

337

308

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Severe influenza infection represents a leading cause of global morbidity and mortality. Although influenza is primarily considered a viral infection that results in pathology limited to the respiratory system, clinical reports suggest that influenza infection is frequently associated with a number of clinical syndromes that involve organ systems outside the respiratory tract. A comprehensive MEDLINE literature review of articles pertaining to extra‐pulmonary complications of influenza infection, using organ‐specific search terms, yielded 218 articles including case reports, epidemiologic investigations, and autopsy studies that were reviewed to determine the clinical involvement of other organs. The most frequently described clinical entities were viral myocarditis and viral encephalitis. Recognition of these extra‐pulmonary complications is critical to determining the true burden of influenza infection and initiating organ‐specific supportive care.

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Section: Resultsmentioning

confidence: 99%

The hidden burden of influenza: A review of the extra‐pulmonary complications of influenza infection

Sellers

Hagan

Hayden

et al. 2017

Influenza Resp Viruses

337

308

View full text Add to dashboard Cite

show abstract

“…Elevation of CPK levels was frequently observed in patients treated at our hospital, and elevation of CPK and AST levels suggest that muscle inflammation was present in these patients. Myositis (with or without rhabdomyolysis) has been associated previously to influenza infections ( 18 – 21 ). Of note, elevated CPK levels were observed in patients with and without confirmed influenza virus infections.…”

Section: Discussionmentioning

confidence: 99%

Severe Pneumonia Associated with Pandemic (H1N1) 2009 Outbreak, San Luis Potosí, Mexico

Gómez-Gómez¹,

Magaña-Aquino²,

García-Sepúlveda³

et al. 2010

Emerg. Infect. Dis.

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“…It is more often seen in school-aged boys and is generally self-limited without sequelae [4,7]. In adults, a less characteristic muscle complication may also occur, with generalized weakness and rhabdomyolysis, often leading to myoglobinuria, and predominantly associated with influenza A virus infection [8,9]. Patients with severe rhabdomyolysis can develop a life-threatening acute renal failure [10] or compartment syndrome [11].…”

Section: Introductionmentioning

confidence: 99%

Productive Infection of Human Skeletal Muscle Cells by Pandemic and Seasonal Influenza A(H1N1) Viruses

et al. 2013

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Besides the classical respiratory and systemic symptoms, unusual complications of influenza A infection in humans involve the skeletal muscles. Numerous cases of acute myopathy and/or rhabdomyolysis have been reported, particularly following the outbreak of pandemic influenza A(H1N1) in 2009. The pathogenesis of these influenza-associated myopathies (IAM) remains unkown, although the direct infection of muscle cells is suspected. Here, we studied the susceptibility of cultured human primary muscle cells to a 2009 pandemic and a 2008 seasonal influenza A(H1N1) isolate. Using cells from different donors, we found that differentiated muscle cells (i. e. myotubes) were highly susceptible to infection by both influenza A(H1N1) isolates, whereas undifferentiated cells (i. e. myoblasts) were partially resistant. The receptors for influenza viruses, α2-6 and α2-3 linked sialic acids, were detected on the surface of myotubes and myoblasts. Time line of viral nucleoprotein (NP) expression and nuclear export showed that the first steps of the viral replication cycle could take place in muscle cells. Infected myotubes and myoblasts exhibited budding virions and nuclear inclusions as observed by transmission electron microscopy and correlative light and electron microscopy. Myotubes, but not myoblasts, yielded infectious virus progeny that could further infect naive muscle cells after proteolytic treatment. Infection led to a cytopathic effect with the lysis of muscle cells, as characterized by the release of lactate dehydrogenase. The secretion of proinflammatory cytokines by muscle cells was not affected following infection. Our results are compatible with the hypothesis of a direct muscle infection causing rhabdomyolysis in IAM patients.

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High Incidence of Acute Myositis with Type A Influenza Virus Infection in the Elderly.

Cited by 27 publications

References 6 publications

The hidden burden of influenza: A review of the extra‐pulmonary complications of influenza infection

The hidden burden of influenza: A review of the extra‐pulmonary complications of influenza infection

Severe Pneumonia Associated with Pandemic (H1N1) 2009 Outbreak, San Luis Potosí, Mexico

Productive Infection of Human Skeletal Muscle Cells by Pandemic and Seasonal Influenza A(H1N1) Viruses

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