High incidence of dyslipidaemia in the offspring of Greek men with premature coronary artery disease

Rallidis, Lοukianos S.; Papageorgakis, N.; Megalou, A. A.; Exadactylos, Nikolaos; Tsitouris, George; Papasteriadis, E.

doi:10.1053/euhj.1997.0770

Cited by 11 publications

(7 citation statements)

References 24 publications

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“…4,8 The results of our study agree with the study conducted by Widhalm et al 9 and Rallidis et al 10 These studies showed a higher level of TC/HDL and LDL/HDL when these ratios were compared between groups.…”

Section: Discussionsupporting

confidence: 92%

Assessment of lipid profile and some risk factors of atherosclerosis in children whose parents had early onset coronary artery disease

et al. 2017

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Background/Aim: The objective of our study was to analyze the lipid profile and some risk factors of atherosclerosis such as oxidized-low density lipoprotein (ox-LDL), small dense LDL (sd LDL) in the offspring of patients with premature coronary heart disease (CHD). Population and Methods: Children whose parents had early onset CHD were matched with age and sex pairs. Study and controls were analyzed for lipid levels, apolipoproteins (Apo-A,B,E), ox-LDL, sd LDL and lipoprotein (a) [Lp(a)]. The data were evaluated with SPSS using "Student t and Mann-Whitney U" tests. Results:The study group children (n: 43) had higher LDL, Lp(a) and ox-LDL levels, ratios of TC/HDL, Apo-B/A, LDL/HDL and ox-LDL/HDL (p<0.05) than control group. Conclusion: These findings suggest that dyslipidemia and increased LDL, Lp(a) and ox-LDL levels are common in the offspring of patients with early onset CHD and account largely for their familial predisposition for CHD.

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Section: Discussionsupporting

confidence: 92%

Assessment of lipid profile and some risk factors of atherosclerosis in children whose parents had early onset coronary artery disease

et al. 2017

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“…However, in the studies conducted by Dutta et al and Rallidis et al there was no statistically significant difference in the mean BMI values between the two groups. 9,10 In the study conducted by Dutta et al, the children were in the age group of 5-18 years and the sample size was only 90 (45 cases and 45 controls) which was small when compared to the present study. In the study conducted by Rallidis et al, even though the sample size was adequate (104 cases and 89 controls) the age group of the children was between 6 years to 25 years of age which was very different from our study which only included children between the age group of 10-18 years.…”

Section: Body Mass Index (Bmi) Comparisoncontrasting

confidence: 56%

Screening for metabolic syndrome in children aged 10-18 years with parental history of premature coronary artery disease

Rao

Hegade

2018

Int J Contemp Pediatr

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Background: The metabolic syndrome is appearing with increasing frequency in children and adolescents and is characterized by the clustering of abdominal obesity, impaired fasting blood glucose (FBS), hypertriglyceridemia, low HDL cholesterol and hypertension. Objective of this study was to screen for components of metabolic syndrome in children aged 10-18 years with parental history of premature coronary artery disease (CAD) and to compare them with children without parental history of premature coronary artery disease.Methods: A total of 90 children each between the ages of 10-18 years were selected as the study group and comparison group. These children were screened for components of metabolic syndrome like fasting blood sugar, hypertension, obesity and dyslipidemia. Diet and hours of physical activity were assessed. Statistical analysis was carried out through SPSS for windows (version 17.0).Results: The most common component of metabolic syndrome in the study group was abnormal FBS followed by elevated triglycerides, low HDL cholesterol, obesity and hypertension. The mean values of FBS, Systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol, triglycerides were found to be significantly higher in the study group. Children in the study group had a higher mean body mass index (BMI) and a history of excessive oily food intake with a sedentary lifestyle.Conclusions: Children with parental history of premature coronary artery disease have higher incidence of dyslipidemia and abnormal FBS. Children in the study group had a sedentary lifestyle with unhealthy diet practices.

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“…(5–7) Rallidis et al . (23) and Parmar et al . (24) showed that there was a correlation between lipid levels of parents and their children and the strongest father-offspring correlation was with TC values.…”

Section: Discussionmentioning

confidence: 96%

The study of lipid profile, diet and other cardiovascular risk factors in children born to parents having premature ischemic heart disease

Savitha

Sandeep

2011

Indian J Community Med

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Background:Dyslipidemia is a marker for ischemic heart disease (IHD), which can be detected in early childhood and tracks to adulthood. Dyslipidemia, along with factors like diet, obesity and sedentary activity, increases the risk of a child developing IHD in adulthood. Early detection and modification of these risk factors can prevent IHD.Objectives:To study the lipid profile in children born to parents with history of premature IHD and also to study the effect of diet, lifestyle factors, and obesity in the study group.Materials and Methods:Fifty children of parents with premature IHD and 50 control children without any family history of IHD were analyzed for cardiovascular risk factors such as lipid profile, body mass index (BMI) and hypertension. The effects of modifiable risk factors like diet and physical activity on lipid profile were analyzed. The correlation between parent and child lipid profile was studied.Results:Mean total cholesterol, low density lipoprotein cholesterol and triglycerides were significantly higher (P<0.05) in children with family history of IHD as compared to children without family history. There was a positive correlation between lipid levels of parents and their children. Children with elevated BMI, a sedentary lifestyle, and excess oily/junk diet intake showed increased incidence of dyslipidemia (P<0.05).Conclusions:Children of IHD patients have significant incidence of dyslipidemia. The risk factors like BMI, diet and physical activity increase the incidence of dyslipidemia. Therefore, all children of premature IHD patients should be screened for dyslipidemia.

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High incidence of dyslipidaemia in the offspring of Greek men with premature coronary artery disease

Cited by 11 publications

References 24 publications

Assessment of lipid profile and some risk factors of atherosclerosis in children whose parents had early onset coronary artery disease

Assessment of lipid profile and some risk factors of atherosclerosis in children whose parents had early onset coronary artery disease

Screening for metabolic syndrome in children aged 10-18 years with parental history of premature coronary artery disease

The study of lipid profile, diet and other cardiovascular risk factors in children born to parents having premature ischemic heart disease

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