High incidence of hepatitis B virus infection in B‐cell subtype non‐Hodgkin lymphoma compared with other cancers

Wang, Feng; Xu, Rui‐Hua; Han, Bing; Shi, Yan; Luo, Hui; Jiang, Wen Qi; Lin, Tong; Huang, Hui Qiang; Xia, Zhong Jun; Guan, Zhong

doi:10.1002/cncr.22549

Cited by 113 publications

(129 citation statements)

References 49 publications

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“…Recent reports examining HBV-DNA in serum have shown that occult HBV infection further adds to the associations of HBsAgpositive HBV infection with NHL and chronic lymphocytic leukemia. [30][31][32] It is also possible that some persons can be positive for HBV-DNA in hepatocytes or lymphocytes or both but negative in serum, which would further affect the association between HBV infection and NHL. …”

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confidence: 99%

Hepatitis viruses and non-Hodgkin lymphoma: epidemiology, mechanisms of tumorigenesis, and therapeutic opportunities

Marcucci

Mele

2011

Blood

227

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Over the past 2 decades considerable evidence has accumulated on the association between hepatitis C virus (HCV) and hepatitis B virus (HBV) and several hematologic malignancies, most notably B-cell non-Hodgkin lymphoma (NHL). In this review we summarize this evidence, address possible mechanisms whereby hepatitis viruses may contribute to lymphomagenesis, and discuss the therapeutic fallouts from this knowledge. Most of this evidence is on HCV, and this is the main focus of the review. Moreover, we mainly address the association with NHL, the most prevalent hematologic malignancy, and the most extensively investigated with regard to an association with hepatitis viruses. Available evidence on the association with other hematologic malignancies is also addressed briefly. (Blood. 2011;117(6):1792-1798) Hepatitis C virus and hepatitis B virusHepatitis C virus (HCV) is a positive, single-stranded RNA virus, member of the Flaviviridae family. 1 During its replicative cycle it goes through a negative-stranded RNA, but not DNA, intermediate, so that integration of HCV nucleic acid sequences into the host genome seems unlikely. As such, it lacks a pivotal property of classical oncogenic retroviruses. The HCV genome produces a single polyprotein that is proteolytically processed by viral and cellular proteases to produce structural (nucleocapsid, E1, E2) and nonstructural (NS) proteins (NS2, NS3, NS4A, NS4B, NS5A, and NS5B).Hepatitis B virus (HBV) is a small DNA virus, member of the Hepadnaviridae family. 2 It presents the unusual feature, for a DNA virus, to replicate through a RNA intermediate and can integrate into the host genome. Moreover, during replication, it undergoes transformation into covalently closed circular DNA. Detection of closed circular DNA HBV-, or negative-stranded HCV-intermediates is important because it identifies genuine viral replication instead of more trivial events such as viral absorption. HBV is characterized by a genome consisting of 4 overlapping open-reading frames: the S gene, encoding envelope proteins; the core gene, encoding the core and "e" proteins; the P gene, encoding DNA polymerase; and the X gene, encoding a transcriptional transactivator.Both viruses can induce acute and chronic hepatitis and are strongly associated with hepatocellular carcinoma (HCC). Epidemiology of non-Hodgkin lymphomaNon-Hodgkin lymphoma (NHL) is the hematologic malignancy with the highest prevalence worldwide. Incidence rates have grown fast up to the beginning of the new millennium, with an annual percentage increase of nearly 3%, which is faster than for most cancers. Thus, delay-adjusted Surveillance, Epidemiology and End Results incidence rate for all races was 11.06/100 000 in 1975, and 20.12/100 000 in 2002. Since then, incidence rates have started to level off, at least in some geographic areas, such as the United States (20.89 in 2007). 3 NHL incidence rates are higher in developed countries such as those in western Europe, North America, and Australia and lower in South America and Asia, but th...

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confidence: 99%

Hepatitis viruses and non-Hodgkin lymphoma: epidemiology, mechanisms of tumorigenesis, and therapeutic opportunities

Marcucci

Mele

2011

Blood

227

210

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“…This has, in part, been ascribed to different rates of hepatitis infections in the general population of the respective countries. Wang reported a decreased rate of HBV infections in patients with T-cell lymphoma compared to patients with B-cell malignancies [28].…”

Section: Discussionmentioning

confidence: 99%

Prevalence and clinical impact of autoimmune diseases and chronic infections in malignant lymphomas at diagnosis

et al. 2011

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There is increasing evidence for the role of chronic antigenic stimulation (CS) in the development of cancer. Clinical data, however, are rare as is the information on outcome. In this study, the occurrence of chronic infections (CI) and autoimmune diseases (AI) in patients with malignant lymphoma at diagnosis was assessed. Of 367 patients (non-Hodgkin´s lymphoma (NHL) N=297, Hodgkin´s lymphoma (HL) N=70), 9.8% (N=36) had a history of chronic antigenic stimulation (4.4% AI, 5.4% CI) at diagnosis. After a median observation time of 74.7 months, 118 patients have died. There were more male patients in this cohort.However, sex ratio among patients with chronic antigenic stimulation was skewed in favor of women (p=0.018), in particular among lymphoma patients with AI (p=0.001). NHL patients with autoimmune diseases showed a tendency to develop diffuse large B cell lymphoma (DLBCL) (8 of 12 AI+NHL patients (66.7%) vs. 100 of 266 non-CS NHL (37.6%); p=0.066).No significant difference in overall survival (OS) between CS and non-CS patients could be observed (median OS after 48 months was: CS 77.7% vs. non-CS 71.8%).In conclusion, chronic antigenic stimulation at diagnosis appears to be associated with a higher prevalence in women, in particular among patients with autoimmune disease. However, no difference in overall survival was observed. This suggests that the presence of chronic inflammatory conditions does not decisively influence the outcome of lymphoma patients.

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“…7 It was reported that HBV plays a role in the development of B-cell NHL. 8 In contrast, primary gastric lymphoma with a T-cell phenotype is relatively rare, accounting for only 7% of primary gastric lymphomas in HTLV-1 infected endemic areas and a relatively large number of such cases are secondary gastric involvement of adult T-cell leukemia. Primary gastric T-cell lymphoma without HTLV-1 infection is rare, and sporadic cases have been reported.…”

Section: Epidemologymentioning

confidence: 99%

Gastric lymphoma

Padala

Zhu

2016

Int J Res Med Sci

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High incidence of hepatitis B virus infection in B‐cell subtype non‐Hodgkin lymphoma compared with other cancers

Cited by 113 publications

References 49 publications

Hepatitis viruses and non-Hodgkin lymphoma: epidemiology, mechanisms of tumorigenesis, and therapeutic opportunities

Hepatitis viruses and non-Hodgkin lymphoma: epidemiology, mechanisms of tumorigenesis, and therapeutic opportunities

Prevalence and clinical impact of autoimmune diseases and chronic infections in malignant lymphomas at diagnosis

Gastric lymphoma

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