High incidence of malignancies in patients with dermatomyositis and polymyositis: An 11-year analysis

Maoz, C; Langevitz, Pnina; Livneh, Avi; Blumstein, Zvia; Sadeh, Menahem; Gur, Hanan; Bark, Ilan; Ehrenfeld, Michael

doi:10.1016/s0049-0172(98)80052-8

Cited by 134 publications

(95 citation statements)

References 38 publications

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“…An increased incidence of cancer in patients with dermatomyositis (DM) (Hidano et al, 1992;Sigurgeirsson et al, 1992;Rose et al, 1994;Selvaag et al, 1994;Zantos et al, 1994;Airio et al, 1995;Chow et al, 1995;Maos et al, 1998) and polymyositis (PM) (Sigurgeirsson et al, 1992;Zantos et al, 1994;Chow et al, 1995;Maos et al, 1998) has been reported in many studies, though with wide variations in the estimated risks. A few studies did not find an excess risk of cancer (Lakhanpal et al, 1986;Manchul et al, 1998) although these were hospital-based case-control studies of limited size.…”

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confidence: 99%

Risk of cancer in patients with dermatomyositis or polymyositis and follow-up implications: a Scottish population-based cohort study

Stockton¹,

2001

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SummaryWe conducted a national, retrospective population-based cohort study of 705 patients hospitalized with a first diagnosis of dermatomyositis (DM) or polymyositis (PM) during 1982-1996 based on linkage of hospital discharge, cancer registration, and death records in Scotland. Risks of cancer were assessed by calculating standardized incidence ratios (SIR). A first malignancy was diagnosed concurrently or subsequently in 50 patients with DM (SIR 7.7, 95% CI 5.7-10.1), and 40 patients with PM (2.1, 1.5-2.9). Significantly elevated risks were observed for lung, cervix uteri, and ovarian cancer in patients with DM, and for Hodgkin's disease in patients with PM. The excess risk of cancer was highest around the time of diagnosis, and for patients with DM remained high for at least 2 years. Risks were elevated for both sexes but only significantly so for females, and were highest in patients aged 45-74 years at the time of diagnosis for DM and 15-44 for PM.

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confidence: 99%

Risk of cancer in patients with dermatomyositis or polymyositis and follow-up implications: a Scottish population-based cohort study

Stockton¹,

2001

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“…Although individual associations between lymphoproliferative disorders (LPDs) and both DM 4 or SLRs 5 have been reported previously, to our knowledge there are no descriptions of this triad. DM is associated with a five-to seven-fold increase in the incidence of malignancy 4 includ-ing in some, but not all studies, associations with LPDs.…”

Section: Discussionmentioning

confidence: 90%

“…DM is associated with a five-to seven-fold increase in the incidence of malignancy 4 includ-ing in some, but not all studies, associations with LPDs. In the majority of these cases there is a close temporal association between the development of the LPD and DM.…”

Section: Discussionmentioning

confidence: 99%

Dermatomyositis and sarcoid-like reaction associated with multiple myeloma treated effectively by high-dose chemotherapy and autologous peripheral blood stem cell transplantation

Chakraverty

Rabin

Peggs

et al. 2001

Bone Marrow Transplant

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Summary:We report the case of a 46-year-old male who developed dermatomyositis and a sarcoid-like reaction in association with testicular relapse of multiple myeloma. The myositis progressed despite chemotherapy directed at the underlying malignant disorder and immunosuppressive treatment. There was, however, a dramatic and sustained response to high-dose chemotherapy and autologous peripheral blood stem cell transplantation which resulted in resolution of the myopathy and partial resolution of the sarcoid-like reaction. This case report highlights the potential of autologous stem cell transplantation as treatment for para-neoplastic disorders associated with haematological malignancies. Bone Marrow Transplantation (2001) 27, 1215-1217. Keywords: multiple myeloma; autologous PBSCT; dermatomyositis; sarcoidosis The presenting clinical features of multiple myeloma are protean and reflect the direct effects of clonal plasma cell proliferation (eg bone marrow failure), the activity of monoclonal antibody (eg amyloid deposition), or the consequence of a complex inter-relationship between the abnormal clone and the host bone marrow micro-environment (eg bone disease). The pathogenesis of the various 'paraneoplastic' disorders which occur in association with myeloma, such as axonal or demyelinating neuropathy, is less certain although antibodies with specificity for proteins expressed by affected tissues, amyloid deposition or changes in cytokine production patterns have all been proposed as potential mechanisms. The optimal treatment for this group of disorders has not been defined and their impact upon prognosis is not known. We report for the first time the effectiveness of high-dose chemotherapy and peripheral blood stem cell transplantation (PBSCT) as treatment for a para-neoplastic disorder associated with multiple myeloma. Case reportA 46-year-old man presented with a 3 month history of general malaise and 2 week history of vomiting in March 1998. There was no significant past medical history. On examination he appeared unwell and short of breath at rest. He had a raised venous pressure, peripheral oedema and bilateral inspiratory crepitations on chest examination. FBC at presentation was: Hb 8.2 g/dl, white cell count 5.2 × 10 9 /l and platelets 163 ϫ 10 9 /l. Renal function tests confirmed acute renal failure with a creatinine of 844 umol/l (normal range 62-130) and urea 46.4 mmol/l (normal range 2.8-7.6). Corrected serum calcium was 3.43 mmol/l. Chest Xray showed changes consistent with pulmonary oedema. Serum electrophoresis confirmed an IgG lambda paraprotein of 70 g/l. No urinary Bence-Jones protein was detected. Skeletal survey revealed no lytic lesions. Bone marrow trephine was diffusely fibrotic with deposition of collagen (grade 4) and heavy infiltration by neoplastic plasma cells (CD138 positive, lambda light chain restriction). Most plasma cells had the features of plasmblasts. Renal biopsy showed a cast nephropathy.The diagnosis was of IgG lambda myeloma complicated by hypercalcaemia and acute rena...

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“…The increased risk of malignancy in patients with inflammatory myopathies such as dermatomyositis and polymyosistis is well-recognized, with prevalence ranging from 6% to 45% [17] . Necrotizing myopathy, however, has rarely been reported in association with cancer in the literature.…”

Section: Discussionmentioning

confidence: 99%

Paraneoplastic necrotizing myopathy in association with metastatic malignant melanoma: two case reports and a review of the literature

Peterson

Buehring

Rush

et al. 2015

CRCP

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Necrotizing myopathy is a rare subtype of inflammatory myopathy characterized predominantly by muscle weakness without inflammation. While the association of malignancy and inflammatory myopathies such as dermatomyositis and polymyositis is well-recognized, necrotizing myopathy has rarely been reported in association with cancer and, to our knowledge, has not been previously reported in association with melanoma. We report two cases of necrotizing myopathy in association with metastatic malignant melanoma.

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High incidence of malignancies in patients with dermatomyositis and polymyositis: An 11-year analysis

Cited by 134 publications

References 38 publications

Risk of cancer in patients with dermatomyositis or polymyositis and follow-up implications: a Scottish population-based cohort study

Risk of cancer in patients with dermatomyositis or polymyositis and follow-up implications: a Scottish population-based cohort study

Dermatomyositis and sarcoid-like reaction associated with multiple myeloma treated effectively by high-dose chemotherapy and autologous peripheral blood stem cell transplantation

Paraneoplastic necrotizing myopathy in association with metastatic malignant melanoma: two case reports and a review of the literature

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