High Incidence of Malignancy in Polyomavirus-Associated Nephropathy in Renal Transplant Recipients

Chen, C.-H.; Wen, Mei‐Chin; Wang, M.; Lian, Jong-Da; Cheng, Chi‐Hung; Wu, Meng‐Che; Yu, T.-M.; Chuang, Ya‐Wen; Chang, Deching; Shu, Kuo‐Hsiung

doi:10.1016/j.transproceed.2010.02.068

Cited by 22 publications

(14 citation statements)

References 8 publications

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“…Furthermore, a statistically significant association between urine cytological evidence of PyV infection (decoy cells) and BC was also demonstrated in immunocompetent patients (18). Despite this experimental and epidemiological evidence, clinical cases of PyV-associated urological malignancies are rare and presented mainly as isolated case reports, mostly in transplant recipients or rarely in immunocompetent patients (17,(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52).…”

Section: Discussionmentioning

confidence: 99%

Archetype and Rearranged Non-coding Control Regions in Urothelial Bladder Carcinoma of Immunocompetent Individuals

Anzivino

Zingaropoli

Iannetta

et al. 2016

CGP

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Section: Discussionmentioning

confidence: 99%

Archetype and Rearranged Non-coding Control Regions in Urothelial Bladder Carcinoma of Immunocompetent Individuals

Anzivino

Zingaropoli

Iannetta

et al. 2016

CGP

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“…13 A recent study also described an association between BK PVN and increased incidence of malignancy in patients with renal allografts. 14 Cytomegalovirus is an opportunistic viral infection that predominantly affects immunocompromised patients, although it can cause disease in native as well as renal allografts. Cytomegalovirus is very common in the general population, with seropositivity ranging between 30% and 97%.…”

Section: Background and Clinical Featuresmentioning

confidence: 99%

Coinfection by Cytomegalovirus and BK Polyomavirus in the Renal Allograft

Shahin¹,

Rabbani²,

Bracamonte³

2012

Pathology Case Reviews

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Viral-induced allograft dysfunction is a significant cause of morbidity and mortality in renal allograft recipients. BK polyomavirus nephropathy continues to be the most common viral disease in renal allografts, although other viruses such as cytomegalovirus (CMV) and adenovirus can have devastating impact on graft function. Proper identification of viral pathogens and distinction from other types of nephritis can be challenging, particularly when the viral infection is at an early stage or when viral inclusions are not frequent. BK polyomavirus nephropathy has occasionally been reported in patients with coexisting CMV infection of other sites or with coinfection documented by serological examination. However, the finding of dual viral infection within a single renal allograft biopsy is unusual. Identification of 1 type of virus within the renal allograft does not preclude the possibility of a second pathological process. This review addresses the key pathological features of BK and CMV nephritis, which should prompt the pathologist to order confirmatory studies to distinguish viral infection from cellular rejection or other forms of allograft nephritis.

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“…There is lack of data to indicate a definitive association between BKV and human cancers (Noel et al, 1994;Husain et al, 2009;Abend et al, 2009;Wang et al, 2009;Roberts et al, 2008;Chen et al, 2010). Presence of polyoma virus in the biopsy specimen may mimick high grade transitional cell carcinoma (Seftel et al, 1996).…”

Section: Role Of Virus In the Carcinogenesis Of Urothelial Carcinomamentioning

confidence: 99%

Urothelial Carcinoma in Renal Transplant Recipients

Lai¹,

Wang²,

Tai³

2011

Kidney Transplantation - New Perspectives

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High Incidence of Malignancy in Polyomavirus-Associated Nephropathy in Renal Transplant Recipients

Cited by 22 publications

References 8 publications

Archetype and Rearranged Non-coding Control Regions in Urothelial Bladder Carcinoma of Immunocompetent Individuals

Archetype and Rearranged Non-coding Control Regions in Urothelial Bladder Carcinoma of Immunocompetent Individuals

Coinfection by Cytomegalovirus and BK Polyomavirus in the Renal Allograft

Urothelial Carcinoma in Renal Transplant Recipients

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