High Incidence of Positive Autoantibodies against Thyroid Peroxidase and Thyroglobulin in Patients with Sarcoidosis

Nakamura, Hirotoshi; Genma, Rieko; Mikami, Takuma; Kitahara, Akira; Natsume, Hiroko; Andoh, Shinichiro; Nagasawa, Shinsuke; Nishiyama, Kozo; Chida, Kingo; Sato, Atsuhiko; Takai, Yoshimi

doi:10.1046/j.1365-2265.1997.1630976.x

Cited by 58 publications

(34 citation statements)

References 20 publications

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“…11 However, larger studies have reported increased levels of TPOAbs in sarcoidosis patients. 8,10 In agreement with the latter, we also found significantly increased TPOAbs in female sarcoidosis patients compared to controls, and TPOAbs were significantly associated with clinical AITD.…”

Section: Discussionsupporting

confidence: 77%

“…8 However, the results remain conflicting, with most of the published data limited to case reports, 9 and in only one study has a complete thyroid work-up been performed. 8 Controversy also exists regarding the presence of thyroid antibodies in sarcoidosis patients, with studies pointing to increased prevalence of antithyroid peroxidase antibodies (TPOAbs) and antithyroglobulin antibodies (TGAbs) 10 in sarcoidosis patients, while others have failed to document any differences. 11 Data concerning TSH receptor antibodies (TRAbs) are rather scarce, most of them derived from case reports; meanwhile, in a prospective study by Antonelli et al 12 the authors failed to demonstrate increased TRAbs titles in sarcoidosis.…”

Section: Introductionmentioning

confidence: 99%

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Increased primary autoimmune thyroid diseases and thyroid antibodies in sarcoidosis: evidence for an under-recognised extrathoracic involvement in sarcoidosis?

Malli¹,

Bargiota²,

Theodoridou³

et al. 2012

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OBJEcTIVE AND DEsIGN: sarcoidosis has been associated with thyroid diseases. However, until today no definite conclusions have been drawn. We aimed to assess the frequency of thyroid disorders and the levels of thyroid hormones and thyroid antibodies in 68 sarcoidosis patients and 75 controls. Additionally, we performed ultrasonography and fine-needle aspiration. rEsULTs: In this prospective case control study conducted in the University Hospital of Larissa, Greece, overt thyroid disease was present in 29.4% of patients and 16.1% of patients presented clinical autoimmune thyroid disease. sarcoidosis patients had a significantly higher frequency of serological autoimmunity. Female patients had significantly increased frequency of positive TsH receptor antibodies (TrAbs) and antithyroid peroxidase antibodies (TPOAbs) when compared to gender-matched controls (40% vs 0%, p<0.001, and 28.8% vs 11.86%, p=0.029, respectively). The hypoechoic pattern of the thyroid was more frequent in female patients vs controls (p<0.001). Male patients had a higher frequency of TrAbs and hypoechoic pattern of the thyroid gland (43.4% vs 0%, p=0.002, and 39.1% vs 6.25%, p=0.021, respectively). Indices of thyroid autoimmune disease were significantly more frequent in sarcoidosis patients vs gender-matched controls. Increased TPOAbs were significantly associated with clinical autoimmune disease in sarcoidosis. cONcLUsIONs: Overall, the findings derived from this study suggest that thyroid disorders are frequent in sarcoidosis. This association may potentially be the result of increased thyroid antibodies.

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Section: Discussionsupporting

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Increased primary autoimmune thyroid diseases and thyroid antibodies in sarcoidosis: evidence for an under-recognised extrathoracic involvement in sarcoidosis?

Malli¹,

Bargiota²,

Theodoridou³

et al. 2012

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“…A controlled study of 62 patients with pulmonary sarcoidosis reported that 27% had antibodies to thyroid peroxidase and/or thyroglobulin while 7.7%-9.1% of three separate control groups had antibodies (121). The patients with antithyroid antibodies were all older than 40 years of age and when this age group alone was analyzed, 55% of the men and 38% of the women were positive.…”

Section: Sarcoidosismentioning

confidence: 95%

Disease Associations with Autoimmune Thyroid Disease

Jenkins

Weetman

2002

Thyroid

130

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Autoimmune thyroid disease (AITD) is common and occurs frequently in conjunction with other diseases. Many putative disease associations have been suggested for AITD but the validity of these associations is not clear in all cases. It is important to define disease associations correctly because this may offer a means to rationally screen for true associations, may shed light on shared pathophysiologic mechanisms and may be important if the associated disease impacts on patient management. This review has examined the evidence base for a large number of the suggested associations.

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“…Additionally 2 patients had insulin-dependent diabetes mellitus and 1 had premature ovarian failure (28,29). According to a Japanese study, a higher incidence of thyroid autoantibodies may be found in sarcoidosis patients with middle or advanced age and a high prevalence of Hashimoto's thyroiditis (30).…”

Section: Resultsmentioning

confidence: 99%

Sarcoidosis and autoimmune disorders. A case report and review of the literature

Ozkan¹

2015

SOB

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SummarySarcoidosis is a multisystem disease of unknown etiology characterized by clusters of non-necrotizing granulomas and distortion of surrounding tissue. Although some patients are asymptomatic, sarcoidosis can cause a wide range of signs and symptoms often mimicking autoimmune rheumatologic disorders. Combined sarcoidosis and autoimmune disorders is uncommon as a result of either an University Hospital database analysis and literature review. However, given the high prevalence of autoimmunity in the general population, clinicians should be alerted to correctly diagnose and manage patients suspected to have both sarcoidosis and autoimmune disorders. KEY WORDS: sarcoidosis, autoimmunity, connective tissue disease. IntroductionSarcoidosis is a systemic inflammatory disorder that involves multiple tissues and is characterized by a non-caseating granulomatous reaction (1). Despite the etiology is not well understood, there are cellular immune system activation and nonspecific inflammatory response similar to some rheumatologic disease which are considered to play an important role in the pathogenesis (2). Sarcoidosis has been reported in all races and ethnic groups with a marked variations. People from different ages can be affected, but it is particularly sighted among the young adults whose ages range from 20 to 40, with possibly a second peak © C I C E d i z i o n i I n t e r n a z i o n a l i both legs together with the appearance of multiple skin papules. A skin biopsy revealed noncaseating epithelioid genulomas, consistent with the diagnosis of sarcoid granulomatosis dermatitis. Then, the patient started a treatment with oral prednisolone tablets (initially 0.75mg/kg body weight then tapering) showing a complete recovery of both skin lesions and leg sign and symptoms. Recognition of cutaneous sarcoid lesions was important in our patient because they provided a visible clue to the contribution of sarcoidosis for patient symptoms. Nevertheless, the diagnosis of cutaneous lesions in a patient with RA and sarcoidosis may be misleading because lesions can exhibit many different morphologies common to both diseases. Literature reviewSarcoidosis is a T helper 1 (Th1) mediated granulomatous disease, with unknown etiology, involving more than one organ. Sarcoidosis may mimic a number of rheumatic diseases or may coexist side by side. It can commonly present with clinical findings that are indicative of vasculitis and spondyloarthritis or connective tissue diseases, including both primary Sjogren's Syndrome, Systemic Lupus Erythematosus, rheumatoid arthritis, and sarcoidosis (1). Some constellations of clinical signs or symptoms are almost pathognomonic for sarcoidosis, including bilateral hilar nodal enlargement as an isolated clinical finding, erythema nodosum with bilateral hilar adenopathy (Lofgren Syndrome), and uveitis combined with fever plus parotiditis (Heerfordt Syndrome). Excluding Lofgren's and Heerfordt's Syndromes, the diagnosis of sarcoidosis requires a tissue biopsy confirming granulomatous inflammat...

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High Incidence of Positive Autoantibodies against Thyroid Peroxidase and Thyroglobulin in Patients with Sarcoidosis

Abstract: The data show a remarkably high incidence of thyroid autoantibodies in patients of middle of advanced age with sarcoidosis, especially in males, and a higher prevalence of Hashimoto's thyroiditis than in previous reports.

Cited by 58 publications

References 20 publications

Increased primary autoimmune thyroid diseases and thyroid antibodies in sarcoidosis: evidence for an under-recognised extrathoracic involvement in sarcoidosis?

Increased primary autoimmune thyroid diseases and thyroid antibodies in sarcoidosis: evidence for an under-recognised extrathoracic involvement in sarcoidosis?

Disease Associations with Autoimmune Thyroid Disease

Sarcoidosis and autoimmune disorders. A case report and review of the literature

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