High intake of fruit and vegetables is related to low oxidative stress and inflammation in a group of patients with type 2 diabetes

Åsgård, Rikard; Rytter, Elisabet; Basu, Samar; Abramsson‐Zetterberg, Lilianne; Möller, Lennart; Vessby, Bengt

doi:10.3402/fnr.v51i4.1625

Cited by 5 publications

(6 citation statements)

References 26 publications

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“…Among the most important antioxidants are fibers, polyphenols, flavonoids, vitamins A, B, C and E and tocopherols 51. Although a study in 54 patients with T2DM detected a significant association between high intakes of fruit and vegetables with decreased OS,52 we failed to detect the same among our study participants. The lack of an association with D-ROM levels in the DIANA and ESTHER study may be explained by the imprecise assessment of nutrition.…”

Section: Discussioncontrasting

confidence: 78%

Factors associated with high oxidative stress in patients with type 2 diabetes: a meta-analysis of two cohort studies

Anusruti

Yang

Gào

et al. 2020

BMJ Open Diab Res Care

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ObjectiveOur objective is to identify the potential factors associated with serum Diacron’s reactive oxygen metabolites test (D-ROM) levels of patients with type 2 diabetes mellitus (T2DM) by conducting cross-sectional and longitudinal analyses in two large cohorts and further strengthening these results by performing a meta-analysis.MethodsSerum D-ROM concentrations were measured in 1045 and 1101 patients with T2DM from two independent cohort studies from Germany at baseline and repeatedly 3–4 years later. The cross-sectional and longitudinal associations of various potential determinants with D-ROM levels were assessed with a backwards selection algorithm in multivariable adjusted models.ResultsIn the meta-analysis of the cross-sectional analysis, female sex, low education, obesity, smoking, high total cholesterol, hemoglobin A1c ≥7%, no diabetes medication, a history of myocardial infarction, heart failure, a history of cancer and C reactive protein levels (CRP) >3 mg/L were statistically significantly associated with increased D-ROM levels in patients with T2DM. The meta-analysis of the longitudinal analysis revealed that old age, female sex, obesity, smoking, physical inactivity, high alcohol consumption, ≥5 years since diabetes diagnosis and CRP levels between 3 mg/L and 10 mg/L were statistically significantly associated with D-ROM levels measured 3–4 years later.Conclusions (validity, limitations and clinical applicability)This comprehensive analysis confirmed that several modifiable risk factors are being associated with oxidative stress in patients with T2DM within an observational study design. We discuss potential prevention measures against these risk factors that might help to reduce oxidative stress and to prevent some cases of premature mortality in patients with T2DM.

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Section: Discussioncontrasting

confidence: 78%

Factors associated with high oxidative stress in patients with type 2 diabetes: a meta-analysis of two cohort studies

Anusruti

Yang

Gào

et al. 2020

BMJ Open Diab Res Care

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“…C. betacea also successfully decrease the inflammatory biomarkers in the C. betacea treated groups. Previous study showed that carotenoids in fruit and vegetable were associated with anti-inflammatory effects [ 53 ]. The biological mechanisms for the protective effect of greater variety in fruit and vegetable intake are not entirely clear but may be attributed to the singular or synergistic action of several bioactive compounds.…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Tamarillo (Cyphomandra betacea) Extract against High Fat Diet Induced Obesity in Sprague-Dawley Rats

2015

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This study aims to investigate the protective effect of Cyphomandra betacea in adult male Sprague-Dawley rats fed with high fat diet. Rats were fed on either normal chow or high fat diet for 10 weeks for obesity induction phase and subsequently received C. betacea extract at low dose (150 mg kg−1), medium dose (200 mg kg−1), or high dose (300 mg kg−1) or placebo via oral gavages for another 7 weeks for treatment phase. Treatment of obese rats with C. betacea extracts led to a significant decrease in total cholesterol and significant increase in HDL-C (p < 0.05). Also there was a trend of positive reduction in blood glucose, triglyceride, and LDL-C with positive reduction of body weight detected in medium and high dosage of C. betacea extract. Interestingly, C. betacea treated rats showed positive improvement of superoxide dismutase (SOD) activity and glutathione peroxidase (GPx) activity along with a significant increase of total antioxidant status (TAS) (p < 0.05). Further, rats treated with C. betacea show significantly lower in TNF-α and IL-6 activities (p < 0.05). This study demonstrates the potential use of Cyphomandra betacea extract for weight maintenance and complimentary therapy to suppress some obesity complication signs.

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“…A cross-sectional study conducted on diabetic patients also reported that higher intake of “vegetable and fish” dietary pattern is related to a lower creatinine rates [ 29 ]. Vegetables and fish, as components of DII, are identified to have anti-inflammatory effects [ 30 , 31 ]. The DII is a tool to assess the overall impact of a diet on inflammatory potential [ 20 ], and is associated with markers of systemic inflammation including such as IL-6 [ 32 ], and CRP [ 17 ] [..]; IL-6 and CRP are two of the inflammatory biomarkers considered in the calculation of DII [ 20 ].…”

Section: Main Textmentioning

confidence: 99%

The association of dietary inflammatory index with urinary risk factors of kidney stones formation in men with nephrolithiasis

et al. 2020

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Objective: Inflammation plays a leading role in the pathogenesis of nephrolithiasis. The association of the dietary inflammatory index (DII) with urinary lithogenic factors is unclear. This study aimed to evaluate the relation of DII to urinary risk factors of kidney stones formation. Results: Of 264 participants, 61.4% (n = 162), 72% (n = 190), 74.6% (n = 197), 68.6% (n = 181), and 80.3% (n = 212) had hyperoxaluria, hypercreatininuria, hypercalciuria, hyperuricosuria, hypocitraturia, respectively. There was a significant increasing trajectory in urinary calcium, uric acid, and creatinine as well as a decreasing trend in urinary citrate across tertiles of DII score (all P = ≤0.001). After multivariate adjustment for energy intake, age, physical activity and body mass index, high DII scores were associated with elevated odds of having hypercreatininuria (OR = 2.80, 95%CI: 1.10-7.12, P trend = 0.04), hypercalciuria (OR = 7.44, 95%CI: 2.62-21.14, P trend ≤ 0.001), hyperuricosuria (OR = 2.22, 95%CI: 1.001-4.95, P trend = 0.05), and hypocitraturia (OR = 5.84, 95%CI: 2.14-15.91, P trend ≤ 0.001). No association was identified between DII and hyperoxaluria.

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High intake of fruit and vegetables is related to low oxidative stress and inflammation in a group of patients with type 2 diabetes

Cited by 5 publications

References 26 publications

Factors associated with high oxidative stress in patients with type 2 diabetes: a meta-analysis of two cohort studies

Factors associated with high oxidative stress in patients with type 2 diabetes: a meta-analysis of two cohort studies

Protective Effects of Tamarillo (Cyphomandra betacea) Extract against High Fat Diet Induced Obesity in Sprague-Dawley Rats

The association of dietary inflammatory index with urinary risk factors of kidney stones formation in men with nephrolithiasis

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