High-intensity focused ultrasound: advances in technology and experimental trials support enhanced utility of focused ultrasound surgery in oncology

Malietzis, George; Monzon, L.; Hand, J.W.; Wasan, H.; Leen, Edward; Abel, Mark; Muhammad, Aun; Price, Pat; Abel, Phillip B.

doi:10.1259/bjr.20130044

Cited by 55 publications

(46 citation statements)

References 73 publications

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“…The focused energy-deposit could be used for targeting the tumor-mass, which is applied by the recent High-Intensity Focused Ultrasound (HIFU) methodology. This methodology is also called thermal surgery due to the development of temperatures over 50°C in few seconds and has been used for prostate, localized liver tumors, breast and pancreatic tumors [25][26][27][28]. Prostatic HIFU application is not without side effects, in fact as outlined by Elterman et al urosepsis, indwelling catheterization and bladder problems occurred frequently [25].…”

Section: Hyperthermia Heating Equipment and Techniquesmentioning

confidence: 99%

A Brief Overview of Hyperthermia in Cancer Treatment

Baronzio¹,

Parmar²,

Ballerini³

et al. 2014

J Integr Oncol

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Despite the large economic and intellectual efforts, cancer is still not easily treatable disease by conventional therapies. This led ultimately to reconsider hyperthermia, like one of interesting treatment methods connected to immunity and tumor metabolism. Hyperthermia has also the ability to play an additional role when used together with the conventional methods of treatment: surgery, radiotherapy, chemotherapy and immunotherapy. Recent trials in Holland and Germany have demonstrated that hyperthermia can prolong life and decrease disease re-appraisal when used in combination with radiotherapy and chemotherapy. Some tumors seem more responsive than others. In this brief summary we will attempt to give a vision of hyperthermia from a physical stand point, but more importantly we will give clinical and biological aspects. The results obtained in these trials on certain types of cancers such as cervix cancer, recurrent breast cancer and head neck cancer, melanoma, sarcomas, liver, glioblastoma and pancreatic cancer support the use of this technique, although some clinical and technical problems persist and have not been completely resolved.

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Section: Hyperthermia Heating Equipment and Techniquesmentioning

confidence: 99%

A Brief Overview of Hyperthermia in Cancer Treatment

Baronzio¹,

Parmar²,

Ballerini³

et al. 2014

J Integr Oncol

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“…However, with recent advances in ultrasound (US) transducers and image processing techniques, many trials to maximize the strengths and minimize the weaknesses of USg-HIFU are being performed on an ongoing basis, for instance, by adopting 3-dimensional (3D) electronic steering transducers and real-time 3D ultrasonography [1,16,17]. In addition, new USg-HIFU systems allow portability in adopting compact HIFU devices with high-powered equipment.…”

Section: Introductionmentioning

confidence: 99%

Portable high-intensity focused ultrasound system with 3D electronic steering, real-time cavitation monitoring, and 3D image reconstruction algorithms: a preclinical study in pigs

et al. 2014

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Purpose:The aim of this study was to evaluate the safety and accuracy of a new portable ultrasonography-guided high-intensity focused ultrasound (USg-HIFU) system with a 3-dimensional (3D) electronic steering transducer, a simultaneous ablation and imaging module, real-time cavitation monitoring, and 3D image reconstruction algorithms.Methods:To address the accuracy of the transducer, hydrophones in a water chamber were used to assess the generation of sonic fields. An animal study was also performed in five pigs by ablating in vivo thighs by single-point sonication (n=10) or volume sonication (n=10) and ex vivo kidneys by single-point sonication (n=10). Histological and statistical analyses were performed.Results:In the hydrophone study, peak voltages were detected within 1.0 mm from the targets on the y- and z-axes and within 2.0-mm intervals along the x-axis (z-axis, direction of ultrasound propagation; y- and x-axes, perpendicular to the direction of ultrasound propagation). Twenty-nine of 30 HIFU sessions successfully created ablations at the target. The in vivo porcine thigh study showed only a small discrepancy (width, 0.5-1.1 mm; length, 3.0 mm) between the planning ultrasonograms and the pathological specimens. Inordinate thermal damage was not observed in the adjacent tissues or sonic pathways in the in vivo thigh and ex vivo kidney studies.Conclusion:Our study suggests that this new USg-HIFU system may be a safe and accurate technique for ablating soft tissues and encapsulated organs.

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“…Based on experience treating benign tumors, there are now numerous experimental studies and small patient series regarding the treatment of malignancies [56], in particular, pancreatic tumors, breast cancer, prostate cancer, renal tumors, liver tumors, and brain tumors. A further oncological application that is possible with currently available systems is the treatment of bone metastases [57].…”

Section: Mr-guided Focused Ultrasoundmentioning

confidence: 99%

White Paper: Interventional MRI: Current Status and Potential for Development Considering Economic Perspectives, Part 2: Liver and Other Applications in Oncology

Barkhausen

Kahn

Krombach

et al. 2017

Fortschr Röntgenstr

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Background MRI is attractive for guiding and monitoring interventional procedures due to its high intrinsic soft tissue contrast and the possibility to measure flow and cardiac function. Methods Technical solutions have been developed for all procedural steps including imaging guidance, MR-safe catheters and instruments and patient monitoring. This has led to widening of the clinical applications. Interventional MRI is becoming increasingly important for the treatment of patients suffering from malignant diseases. The detectability of masses and consequently their accessibility for biopsy is higher, compared to other modalities, due to the high intrinsic soft tissue contrast of MRI. Temperature-dependent sequences allow for minimally invasive and tissue-sparing ablation (A-0 ablation). Conclusion Interventional MRI has become established in the clinical routine for a variety of indications, including biopsies and tumor ablation. Since the economic requirement of covering costs by reimbursement is met and interventional MRI decreases the mortality and morbidity of interventional procedures, broader application of interventional MRI can be expected in the clinical routine in the future. Key points Citation Format

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High-intensity focused ultrasound: advances in technology and experimental trials support enhanced utility of focused ultrasound surgery in oncology

Cited by 55 publications

References 73 publications

A Brief Overview of Hyperthermia in Cancer Treatment

A Brief Overview of Hyperthermia in Cancer Treatment

Portable high-intensity focused ultrasound system with 3D electronic steering, real-time cavitation monitoring, and 3D image reconstruction algorithms: a preclinical study in pigs

White Paper: Interventional MRI: Current Status and Potential for Development Considering Economic Perspectives, Part 2: Liver and Other Applications in Oncology

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