High-Intensity Focused Ultrasound: Heating and Destruction of Biological Tissue

Andreeva, T. A.; Беркович, А. Е.; Bykov, N. Y.; Козырев, С. В.; Lukin, A. Ya.

doi:10.1134/s1063784220090030

Cited by 8 publications

(7 citation statements)

References 21 publications

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“…The pressure of the tip was controlled manually. It should be noted that a further increase in forced frequency could dramatically influence the biological process in the human body-at the border of 30 kHz, cavitation arises with the formation of bubbles with a size of fractions of micrometers, which explains the lack of their visualization [69], when the frequencies of 41.5 and 39.3 kHz correspond to the self-oscillation frequencies of the samples made of 20Kh13 (DIN 1.4021) and 12Kh18N9T (DIN 1.4541), correspondingly [70].…”

Section: Surface Quality Of the Samplesmentioning

confidence: 99%

Influence of Postprocessing on Wear Resistance of Aerospace Steel Parts Produced by Laser Powder Bed Fusion

et al. 2020

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The paper is devoted to the research of the effect of ultrasonic postprocessing—specifically, the effects of ultrasonic cavitation-abrasive finishing, ultrasonic plastic deformation, and vibration tumbling on surface quality, wear resistance, and the ability of real aircraft parts with complex geometries and with sizes less than and more than 100 mm to work in exploitation conditions. The parts were produced by laser powder bed fusion from two types of anticorrosion steels of austenitic and martensitic grades—20Kh13 (DIN 1.4021, X20Cr13, AISI 420) and 12Kh18N9T (DIN 1.4541, X10CrNiTi18-10, AISI 321). The finishing technologies based on mechanical action—plastic deformation, abrasive wear, and complex mechanolysis showed an effect on reducing the submicron surface roughness, removing the trapped powder granules from the manufactured functional surfaces and their wear resistance. The tests were completed by proving resistance of the produced parts to exploitation conditions—vibration fatigue and corrosion in salt fog. The roughness arithmetic mean deviation Ra was improved by 50–52% after cavitation-abrasive finishing, by 28–30% after ultrasonic plastic deformation, and by 65–70% after vibratory tumbling. The effect on wear resistance is correlated with the improved roughness. The effect of used techniques on resistance to abrasive wear was explained and grounded.

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Section: Surface Quality Of the Samplesmentioning

confidence: 99%

Influence of Postprocessing on Wear Resistance of Aerospace Steel Parts Produced by Laser Powder Bed Fusion

et al. 2020

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“…With the known acoustic pressure, it is possible to evaluate the acoustic pressure's amplitude in each moment of the cycle. At the same time, it should be noted that frequency higher than 30 kHz and up to 1 MHz could be harmful to the biological process in the human body since arising cavitation with bubble formation with a diameter less than 1 µm (ultrasound surgery) [85], when ultrasound in the range 2-29 MHz is used in echography; the works should be conducted according to the sanitary norms and rules of production.…”

Section: Quantituve Evaluation Of Cavitation-abrasive Finishing Factorsmentioning

confidence: 99%

Effect of Cavitation Erosion Wear, Vibration Tumbling, and Heat Treatment on Additively Manufactured Surface Quality and Properties

Grigoriev

Metel

Tarasova

et al. 2020

Metals

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The paper is devoted to researching various post-processing methods that affect surface quality, physical properties, and mechanical properties of laser additively manufactured steel parts. The samples made of two types of anticorrosion steels—20kH13 (DIN 1.4021, X20Cr13, AISI 420) and 12kH18N9T (DIN 1.4541, X10CrNiTi18-10, AISI 321) steels—of martensitic and austenitic class were subjected to cavitation abrasive finishing and vibration tumbling. The roughness parameter Ra was reduced by 4.2 times for the 20kH13 (X20Cr13) sample by cavitation-abrasive finishing when the roughness parameter Ra for 12kH18N9T (X10CrNiTi18-10) sample was reduced by 2.8 times by vibratory tumbling. The factors of cavitation-abrasive finishing were quantitatively evaluated and mathematically supported. The samples after low tempering at 240 °C in air, at 680 °C in oil, and annealing at 760 °C in air were compared with cast samples after quenching at 1030 °C and tempering at 240 °C in air, 680 °C in oil. It was shown that the strength characteristics increased by ~15% for 20kH13 (X20Cr13) steel and ~20% for 12kH18N9T (X10CrNiTi18-10) steel than for traditionally heat-treated cast samples. The wear resistance of 20kH13 (X20Cr13) steel during abrasive wear correlated with measured hardness and decreased with an increase in tempering temperatures.

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“…High‐Intensity Focused Ultrasound (HIFU) is a promising method that uses an ultrasound transducer to perform hyperthermia by focusing the energy transducer on a specific area 1–23 . This procedure can be performed without anesthesia and on an outpatient basis because it is possible to adjust the frequency and the intensity of the transducer, as well as the duration of treatment exposure.…”

Section: Introductionmentioning

confidence: 99%

“…This procedure can be performed without anesthesia and on an outpatient basis because it is possible to adjust the frequency and the intensity of the transducer, as well as the duration of treatment exposure. One of the major problems of the HIFU hyperthermia therapy is the careful preparation and comprehensive knowledge of the parameters and variables involved in the procedure due to the high variability from individual to individual, or even for the same individual under different physiological conditions 12 . The hyperthermia therapy by HIFU leads to a mechanical alteration of cells suffering changes in its biological structure because the ultrasonic energy absorbed by the tissue causes a thermal effect.…”

Section: Introductionmentioning

confidence: 99%

Parameter estimation in high‐intensity focused ultrasound therapy

Cardenas

Varon

Cárdenas

2022

Numer Methods Biomed Eng

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Hyperthermia using High‐Intensity Focused Ultrasound (HIFU) is an acoustic therapy for cancer treatment. This technique consists of an increase in the temperature field of the tumor to achieve coagulative necrosis and immediate cell death. Therefore, for having a successful treatment, the physical problem requires to know several properties due to the high variability from individual to individual, or even for the same individual under different physiological conditions. This article presents a numerical simulation of hyperthermia therapy for cancer treatment using HIFU, as well as the estimation of parameters that influence the physical problem. Two mathematical models were considered to solve the forward problem. The acoustic model based on acoustic pressure performs a frequency‐domain study, and the bioheat transfer model a time‐dependent study. These models were solved using Comsol Multiphysics® software in a 2D‐axisymmetric rectangular domain to determine the temperature field. Parameter estimation was coded in Matlab Mathworks® environment using a Bayesian approach. The Markov Chain Monte Carlo method by the Metropolis–Hastings algorithm was implemented, and the simulated temperature measurements were considered. Results suggest that specific HIFU therapy can be performed for each patient by estimating appropriate parameters for cancer treatment and provides the possibility to define procedures before and during the treatment.

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High-Intensity Focused Ultrasound: Heating and Destruction of Biological Tissue

Cited by 8 publications

References 21 publications

Influence of Postprocessing on Wear Resistance of Aerospace Steel Parts Produced by Laser Powder Bed Fusion

Influence of Postprocessing on Wear Resistance of Aerospace Steel Parts Produced by Laser Powder Bed Fusion

Effect of Cavitation Erosion Wear, Vibration Tumbling, and Heat Treatment on Additively Manufactured Surface Quality and Properties

Parameter estimation in high‐intensity focused ultrasound therapy

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