High-Intensity Focused Ultrasound (HIFU) - An Alternative Choice in Prostate Cancer Treatment

Antivascular Ultrasound Therapy Extends Survival of Mice With Implanted Melanomas

“…Histology also demonstrated that pre-existing vascular, neural and other normal structures enveloped by the growing neoplasm were unaffected by the therapy (Bunte et al 2006). These post-antivascular therapy findings are quite different to those described after tumor therapy with high intensity focused ultrasound, where power levels of 1,000 to 20,000 W.cm −2 (Briones et al 2008, Van Leenders et al 2000) lead to localized temperature rises of 85–100°C (Maestroni et al 2008). There is instantaneous coagulative necrosis of all tissues in the therapeutic zone (Susani et al 1993; Van Leenders et al 2000) the histologic changes may, however, not be confined to the target structure and involve adjacent normal tissues (Van Leenders et al 2000).…”

High intensity focused ultrasound (HIFU) for prostate cancer: Current clinical status, outcomes and future perspectives

“…Among publications on HIFU as a primary therapy for prostate cancer, 15 studies report series of at least 50 patients [13,16,17,[20][21][22][23][24][25][26][27][28][29][30][31], while the others report on fewer patients [12,[32][33][34].…”

Detection of gaps between high‐intensity focused ultrasound (HIFU)‐induced lesions using transient axial shear strain elastograms

“…In seven of nine patients with biopsy‐proven localized prostate carcinoma (cT 1‐2 N 0 M 0 ), a vital bilateral tumor was found at the dorsal side of the treated HIFU area . In the other studies of HIFU treatment on prostate cancer, biochemical relapses were observed in 4 of 25 patients; 56% of 71 patients had evidence of prostate cancer progression at the 3‐month follow‐up; the actuarial disease recurrence rates of 140 patients at 5 and 7 yr were 33% and 41%, respectively . One of the reasons for cancer relapse may be the untreated gaps within the planned treatment area .…”