High-intensity focused ultrasound therapy for pancreatic cancer

Sofuni, Atsushi; Asai, Yasufumi; Mukai, Shuntaro; Yamamoto, Kenjiro; Itoi, Takao

doi:10.1007/s10396-022-01208-4

Cited by 16 publications

(14 citation statements)

References 69 publications

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“…Similar to RFA, HIFU is a hyperthermic technique in which ultrasound beams are used to generate acoustic energy to elevate tumour temperature (>60 °C). Unlike RFA and microwave ablation, HIFU is considered non-invasive, with no required anaesthesia [ 159 ] and minimal effect on the surrounding tissues [ 133 , 160 ]. The technique causes coagulative necrosis to the tumour tissue and acoustic cavitation, leading to the collapse of cancer cells [ 161 ].…”

Section: Locoregional Therapiesmentioning

confidence: 99%

Pancreatic Cancer: Challenges and Opportunities in Locoregional Therapies

Bazeed

Day

Garg

2022

Cancers

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Pancreatic cancer (PC) remains the seventh leading cause of cancer-related deaths worldwide and the third in the United States, making it one of the most lethal solid malignancies. Unfortunately, the symptoms of this disease are not very apparent despite an increasing incidence rate. Therefore, at the time of diagnosis, 45% of patients have already developed metastatic tumours. Due to the aggressive nature of the pancreatic tumours, local interventions are required in addition to first-line treatments. Locoregional interventions affect a specific area of the pancreas to minimize local tumour recurrence and reduce the side effects on surrounding healthy tissues. However, compared to the number of new studies on systemic therapy, very little research has been conducted on localised interventions for PC. To address this unbalanced focus and to shed light on the tremendous potentials of locoregional therapies, this work will provide a detailed discussion of various localised treatment strategies. Most importantly, to the best of our knowledge, the aspect of localised drug delivery systems used in PC was unprecedentedly discussed in this work. This review is meant for researchers and clinicians considering utilizing local therapy for the effective treatment of PC, providing a thorough guide on recent advancements in research and clinical trials toward locoregional interventions, together with the authors’ insight into their potential improvements.

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Section: Locoregional Therapiesmentioning

confidence: 99%

Pancreatic Cancer: Challenges and Opportunities in Locoregional Therapies

Bazeed

Day

Garg

2022

Cancers

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“…[ 194–196 ] HIFUS directly harnesses its higher intensities and spatial resolution routinely being used to ablation cancer/tumor in a non‐invasive manner. [ 197,198 ] Foley et al applied 5.7 MHz, 390, 2255, 3310, and 7890 W cm −2 of HIFUS, respectively, to explore the effect of HIFUS on peripheral nerves by measuring the compound motor action potential (CMAP, which is positively correlated with rats motor function recovery) of rat sciatic nerve in a short‐term and long‐term ranges. They found that the CMAP decreased within 4 h or 7 days after HIFUS irradiation and returned to normal levels at 28 days after treatment, and this inhibitory effect became more pronounced with the increase of US power.…”

Section: Acoustic Cue‐based Strategies For Pnrmentioning

confidence: 99%

Physical Cue‐Based Strategies on Peripheral Nerve Regeneration

Wei

Jin

et al. 2022

Adv Funct Materials

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Peripheral nerve injury (PNI) remains an intractable challenge in regenerative medicine. Recently, physical cue-based strategies (e.g., electrical neurostimulation, acoustic radiation, electromagnetic bioregulation, as well as directional fiber guiding, etc.) have drawn increasing attention not only as a stimulator for cell functions modulation and fate determination, but also as a morphology-index for modulating cell phenotype, proliferation, and differentiation, especially for nerve cells. More importantly, the advanced percutaneous power transmission technology, self-power nanotechnology that leverages piezoelectrical/triboelectricity materials, and focused ultrasound and pulsed electromagnetic field technology exhibit the appealing practice potential for achieving low-invasive, wireless, and battery-free neuromodulation. In this review, recent advances of physical cue-based strategies including electrical, acoustic, magnetic, and morphology for PNI are systematically overviewed, and the open challenges for realizing scalable clinical/commercial transformation and future perspectives of these strategies for PNI are concluded.

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“…RFA heats targeted tissue by ionic friction from current, reducing the local increase in temperature above 60 °C and then causing coagulative necrosis ( Yousaf et al, 2020 ). HIFU employs the ultrasonic wave to heat tumor entities, resulting in coagulative necrosis of tumor tissue ( Sofuni et al, 2022 ). Local ablation therapy is more secure and has fewer complications and shorter hospital stays than hepatectomy ( Shin et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Roles of hypoxia-inducible factor in hepatocellular carcinoma under local ablation therapies

Xiao

Liu

et al. 2023

Front. Pharmacol.

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Hepatocellular carcinoma (HCC) is one of the most common digestive malignancies. HCC It ranges as the fifth most common cause of cancer mortality worldwide. While The prognosis of metastatic or advanced HCC is still quite poor. Recently, locoregional treatment, especially local ablation therapies, plays an important role in the treatment of HCC. Radiofrequency ablation (RFA) and high-intensity focused ultrasound (HIFU) ablation are the most common-used methods effective and feasible for treating HCC. However, the molecular mechanisms underlying the actions of ablation in the treatments for HCC and the HCC recurrence after ablation still are poorly understood. Hypoxia-inducible factor (HIF), the key gene switch for adaptive responses to hypoxia, has been found to play an essential role in the rapid aggressive recurrence of HCC after ablation treatment. In this review, we summarized the current evidence of the roles of HIF in the treatment of HCC with ablation. Fifteen relevant studies were included and further analyzed. Among them, three clinical studies suggested that HIF-1α might serve as a crucial role in the RAF treatment of HCC or the local recurrence of HCC after RFA. The remainder included experimental studies demonstrated that HIF-1, 2α might target the different molecules (e.g., BNIP3, CA-IX, and arginase-1) and signaling cascades (e.g., VEGFA/EphA2 pathway), constituting a complex network that promoted HCC invasion and metastasis after ablation. Currently, the inhibitors of HIF have been developed, providing important proof of targeting HIF for the prevention of HCC recurrence after IRFA and HIFU ablation. Further confirmation by prospective clinical and in-depth experimental studies is still warranted to illustrate the effects of HIF in HCC recurrence followed ablation treatment in the future.

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High-intensity focused ultrasound therapy for pancreatic cancer

Cited by 16 publications

References 69 publications

Pancreatic Cancer: Challenges and Opportunities in Locoregional Therapies

Pancreatic Cancer: Challenges and Opportunities in Locoregional Therapies

Physical Cue‐Based Strategies on Peripheral Nerve Regeneration

Roles of hypoxia-inducible factor in hepatocellular carcinoma under local ablation therapies

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