High-intensity interval training is more effective than continuous training to reduce inflammation markers in female rats with cisplatin nephrotoxicity

Leite, Allyne Baía; Lima, Hernando Nascimento; C, Flores; Oliveira, Caroline Assunção; Cunha, Larissa Esterfanne Cavalcante; Neves, Jonas Luz; Correia, Thiago Macêdo Lopes; Melo, Fabrício Freire de; Oliveira, Márcio Vasconcelos; Magalhães, Amélia Cristina Mendes de; Soares, Telma de Jesus; Amaral, Liliany Souza de Brito

doi:10.1016/j.lfs.2020.118880

Cited by 25 publications

(18 citation statements)

References 62 publications

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“…In another study, 12 weeks (3 week −1 ) of descending stair walking (eccentric exercise for knee extensors) was more effective (− 40%) than ascending stair walking training (− 24%) at decreasing TNF-α levels in women (Chow et al 2020 ). While research on humans is limited, non-RET endurance training can precipitate decreased TNF-α levels, however, intensity matters, as 8 weeks (5 week −1 ) of HIIET was more effective than LICET in reducing TNF-α in mouse renal tissue (Leite et al 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“…Regarding NF-κB, in the brain of mice with Parkinson’s disease, 5 weeks (5 week −1 ) of loaded ladder climbing (typical rodent concentric RET protocol) decreased NF-κB expression (Kim et al 2021 ). Moreover, 8 weeks (5 week −1 ) of HIIET was more effective than LICET in reducing NF-κB levels in mouse renal tissue after injury (Leite et al 2021 ). In humans, eccentric RET increased inflammation to a greater degree than equivalent concentric RET, however repeating the same session does not trigger the same inflammatory response.…”

Section: Introductionmentioning

confidence: 99%

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Exercise medicine for cancer cachexia: targeted exercise to counteract mechanisms and treatment side effects

Mavropalias

Sim

Taaffe

et al. 2022

J Cancer Res Clin Oncol

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Purpose Cancer-induced muscle wasting (i.e., cancer cachexia, CC) is a common and devastating syndrome that results in the death of more than 1 in 5 patients. Although primarily a result of elevated inflammation, there are multiple mechanisms that complement and amplify one another. Research on the use of exercise to manage CC is still limited, while exercise for CC management has been recently discouraged. Moreover, there is a lack of understanding that exercise is not a single medicine, but mode, type, dosage, and timing (exercise prescription) have distinct health outcomes. The purpose of this review was to examine the effects of these modes and subtypes to identify the most optimal form and dosage of exercise therapy specific to each underlying mechanism of CC. Methods The relevant literatures from MEDLINE and Scopus databases were examined. Results Exercise can counteract the most prominent mechanisms and signs of CC including muscle wasting, increased protein turnover, systemic inflammation, reduced appetite and anorexia, increased energy expenditure and fat wasting, insulin resistance, metabolic dysregulation, gut dysbiosis, hypogonadism, impaired oxidative capacity, mitochondrial dysfunction, and cancer treatments side-effects. There are different modes of exercise, and each mode has different sub-types that induce vastly diverse changes when performed over multiple sessions. Choosing suboptimal exercise modes, types, or dosages can be counterproductive and could further contribute to the mechanisms of CC without impacting muscle growth. Conclusion Available evidence shows that patients with CC can safely undertake higher-intensity resistance exercise programs, and benefit from increases in body mass and muscle mass.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exercise medicine for cancer cachexia: targeted exercise to counteract mechanisms and treatment side effects

Mavropalias

Sim

Taaffe

et al. 2022

J Cancer Res Clin Oncol

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“…Ten weeks of low-volume, high-intensity interval exercise could improve neutrophil and monocyte function and enhance innate immune system in sedentary adults ( Bartlett et al, 2017 ). Animal research also indicated that interval exercise training could reduce the inflammation induced by cisplatin nephrotoxicity and downregulate the TLR4/NF-κB signaling pathway ( Leite et al, 2021 ). In the present study, we verified that aerobic interval training produces similar anti-inflammatory effects for PM 2.5 -induced inflammation.…”

Section: Discussionmentioning

confidence: 99%

Amelioration of Ambient Particulate Matter (PM2.5)-Induced Lung Injury in Rats by Aerobic Exercise Training

Qin

Fan

et al. 2021

Front. Physiol.

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Ambient particulate matter (PM2.5), as an inflammation-inducing factor, increases the prevalence of lung injury. The aim of this study was to examine the protective effect and mechanism of aerobic exercise on PM2.5 exposure-induced lung injury. Forty Wistar rats were randomly divided into four groups: sedentary+PM2.5 exposure, exercise+PM2.5 exposure, sedentary, and exercise groups. All rats in the exercise-related groups underwent 8-week aerobic interval treadmill training (5daysweek−1, 1hday−1). PM-exposed rats were exposed to ambient PM2.5 (6h day−1) for 3weeks after the 8-week exercise intervention. Then, ventilation function, histopathological changes, and inflammation responses of pulmonary tissue were examined. Results showed that PM2.5 exposure induced lung injury as manifested by decreased pulmonary function, abnormal histopathological changes, and increased pro-inflammatory cytokine levels (tumor necrosis factor-α and Interleukin-1α). Aerobic exercise alleviated the airway obstruction, reduced respiratory muscle strength, bronchial mucosal exfoliation, ultrastructure damage, and inflammatory responses induced by PM2.5 in exercise-related groups. The benefits of exercise were related with the downregulation of p38-mitogen-activated protein kinase (MAPK), and the subsequent inhibition of the pathways of the cyclooxygenase 2 (COX-2) product, prostaglandin E2 (PGE2). Thus, pre-exercise training may be an effective way to protect against PM2.5-induced lung inflammatory injury in rats.

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“…There are several animal studies indicating protective effects of exercise against cisplatin‐induced nephrotoxicity 104–106 . In a study focusing on the effects of exercise on cisplatin‐nephrotoxicity in rats, authors compared protocols employing low, medium, and high intensity exercise.…”

Section: Exercise and Nephrotoxicitymentioning

confidence: 99%

“…Compared to non‐exercising controls, all three training protocols showed protective effects against cisplatin‐induced renal injury and attenuated the increase in TNF‐α, IL‐1β, and IL‐6. However, effects were more robust with high‐intensity training and this was the only protocol effective in preventing negative changes in renal function 105 . The effects of exercise on nephrotoxicity in cancer patients receiving chemotherapy are yet to be evaluated 104 …”

Section: Exercise and Nephrotoxicitymentioning

confidence: 99%

Chemotherapy‐induced toxicity in patients with testicular germ cell tumors: The impact of physical fitness and regular exercise

et al. 2021

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Background: Testicular germ cell tumors (TGCTs) represent ∼95% of testicular malignancies and are the most common type of malignancy in young male adults. While the incidence of TGCTs has increased during the last decades, the advances in treatment, namely introducing cisplatin into the chemotherapy regimen, have made TGCTs highly curable with the 10-year survival rate exceeding 95%. However, in parallel with increased cure rates, survivors may experience acute and late adverse effects of treatment, which increase morbidity, reduce the quality of life, and can be potentially lifethreatening. Chemotherapy-related toxicities include cardiovascular and metabolic diseases, secondary cancer, avascular necrosis, cognitive impairment, cancer-related fatigue, poor mental health-related quality of life, nephrotoxicity, hypogonadism, neurotoxicity, pulmonary toxicity, anxiety, and depression. These treatment-related adverse effects have emerged as important survivorship dilemmas in TGCT cancer survivors. Recently, regular physical exercise has increasingly attracted research and clinical attention as an adjunct therapy for cancer patients.Purpose: Herein, we review the most common chemotherapy-related adverse effects in TGCT survivors and clinical relevance of exercise and increased cardio-respiratory fitness in modulating chemotherapy-related toxicity and quality of life in this population. Results and conclusion:Exercise has positive effects on a spectrum of physical and psychosocial outcomes during and after cancer treatment, and current guidelines on exercise prescription in chronic diseases define the recommended dose (volume and

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High-intensity interval training is more effective than continuous training to reduce inflammation markers in female rats with cisplatin nephrotoxicity

Cited by 25 publications

References 62 publications

Exercise medicine for cancer cachexia: targeted exercise to counteract mechanisms and treatment side effects

Exercise medicine for cancer cachexia: targeted exercise to counteract mechanisms and treatment side effects

Amelioration of Ambient Particulate Matter (PM2.5)-Induced Lung Injury in Rats by Aerobic Exercise Training

Chemotherapy‐induced toxicity in patients with testicular germ cell tumors: The impact of physical fitness and regular exercise

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