High-Intensity Interval Training Versus Moderate Continuous Training in Patients With Heart Failure With Preserved Ejection Fraction: A Systematic Review and Meta-analysis

Siddiqi, Tariq Jamal; Rashid, Ahmed Mustafa; Javaid, Syed Sarmad; Siddiqi, Ahmed Kamal; Usman, Muhammad; Hervir, Oliver; Kamimura, Daisuke; Lavie, Carl J.; Mentz, Robert J; Butler, Javed; Hall, Michael E.

doi:10.1016/j.cpcardiol.2023.101720

Cited by 6 publications

(3 citation statements)

References 24 publications

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“…The present study suggested that HIIT significantly increased LVEF in patients with HfrEF. Due to the significant heterogeneity observed, we conducted a sensitivity analysis and concluded that Papathanasiou et al's ( 16 ) study may have been a potential source of heterogeneity. We analyzed the possible reason why the study focused solely on patients with ischemic cardiomyopathy, hypertensive HF, and a limited number of patients with idiopathic dilated cardiomyopathy, rather than encompassing the entire range of HF conditions.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, the majority of published studies comparing HIIT and MICT in HF have primarily focused on heart failure with preserved ejection fraction (HFpEF). Therefore, it is necessary to clarify the clinical effects of HIIT specifically in HFrEF (15)(16)(17). Furthermore, it is crucial to consider energy expenditure during training when comparing various exercise regimens.…”

Section: Introductionmentioning

confidence: 99%

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High intensity interval training vs. moderate intensity continuous training on aerobic capacity and functional capacity in patients with heart failure: a systematic review and meta-analysis

Yang,

Zhang,

Cheng

et al. 2024

Front. Cardiovasc. Med.

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BackgroundExercise training is commonly employed as a efficacious supplementary treatment for individuals suffering from heart failure, but the optimal exercise regimen is still controversial. The objective of the review was to compare the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on the exercise capacity, cardiac function, quality of life (QoL) and heart rate among patients with heart failure with reduced ejection fraction.MethodsA systematic search was performed using the following eight databases from their inception to July 5, 2023: PubMed, Web of Science, Embase, Cochrane Library, Clinical Trials, China Knowledge Network, Wan fang Data, and the China Biology Medicine databases. The meta-analysis results were presented as mean difference (MD) and 95% confidence interval (CI). The Cochrane Risk of Bias tool was used for the included studies. The Grading of Recommendations Assessment, Development, and Evaluations was used to assess the certainty of evidence.ResultsThirteen randomized controlled trials were included in the study. The results showed that HIIT had a significant positive effect on peak oxygen uptake (MD = 1.78, 95% CI for 0.80–2.76), left ventricular ejection fraction (MD = 3.13, 95% CI for 1.25–5.02), six-minute walk test (MD = 28.13, 95% CI for 14.56–41.70), and Minnesota Living with Heart Failure Questionnaire (MD = −4.45, 95% CI for −6.25 to −2.64) compared to MICT. However, there were no statistically significant differences observed in resting heart rate and peak heart rate.ConclusionsHIIT significantly improves peak oxygen uptake, left ventricular ejection fraction, six-minute walk test, and Minnesota Living with Heart Failure Questionnaire in patients with heart failure with reduced ejection fraction. Additionally, HIIT exhibits greater effectiveness in improving peak oxygen uptake among patients with lower body mass index.Systematic Review Registrationhttps://www.doi.org/10.37766/inplasy2023.7.0100, identifier (INPLASY2023.7.0100).

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

High intensity interval training vs. moderate intensity continuous training on aerobic capacity and functional capacity in patients with heart failure: a systematic review and meta-analysis

Yang,

Zhang,

Cheng

et al. 2024

Front. Cardiovasc. Med.

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“…These results were not confirmed in a larger randomized trial of patients with LVEF ≤ 35%, in which almost half of the patients did not adhere to the recommended training corridors [ 102 ]. Although a cohort of patients with HF and HFpEF displayed no differences in VO 2peak improvement between MCT and HIIT [ 103 ], a meta-analysis of three RCT HFpEF trials recently demonstrated a benefit for HIIT [ 104 ]. When comparing isocaloric HFrEF studies, MCT and HIIT did not differ in VO 2peak [ 105 ] or LVEF improvement at rest [ 106 ].…”

Section: Variation Of Exercise Intensity: Hiit Vs Mctmentioning

confidence: 99%

Relevance of Cardiovascular Exercise in Cancer and Cancer Therapy-Related Cardiac Dysfunction

Wernhart,

Rassaf

2024

Curr Heart Fail Rep

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Purpose of the Review Cancer therapy-related cardiac dysfunction (CTRCD) has been identified as a threat to overall and cancer-related survival. Although aerobic exercise training (AET) has been shown to improve cardiorespiratory fitness (CRF), the relationship between specific exercise regimens and cancer survival, heart failure development, and reduction of CTRCD is unclear. In this review, we discuss the impact of AET on molecular pathways and the current literature of sports in the field of cardio-oncology. Recent Findings Cardio-oncological exercise trials have focused on variations of AET intensity by using moderate continuous and high intensity interval training, which are applicable, safe, and effective approaches to improve CRF. Summary AET increases CRF, reduces cardiovascular morbidity and heart failure hospitalization and should thus be implemented as an adjunct to standard cancer therapy, although its long-term effect on CTRCD remains unknown. Despite modulating diverse molecular pathways, it remains unknown which exercise regimen, including variations of AET duration and frequency, is most suited to facilitate peripheral and central adaptations to exercise and improve survival in cancer patients.

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Exercise, cancer, and the cardiovascular system: clinical effects and mechanistic insights

Wernhart,

Rassaf

2024

Basic Res Cardiol

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Cardiovascular diseases and cancer are the leading causes of death in the Western world and share common risk factors. Reduced cardiorespiratory fitness (CRF) is a major determinant of cardiovascular morbidity and cancer survival. In this review we discuss cancer- induced disturbances of parenchymal, cellular, and mitochondrial function, which limit CRF and may be antagonized and attenuated through exercise training. We show the impact of CRF on cancer survival and its attenuating effects on cardiotoxicity of cancer-related treatment. Tailored exercise programs are not yet available for each tumor entity as several trials were performed in heterogeneous populations without adequate cardiopulmonary exercise testing (CPET) prior to exercise prescription and with a wide variation of exercise modalities. There is emerging evidence that exercise may be a crucial pillar in cancer treatment and a tool to mitigate cardiotoxic treatment effects. We discuss modalities of aerobic exercise and resistance training and their potential to improve CRF in cancer patients and provide an example of a periodization model for exercise training in cancer.

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High-Intensity Interval Training Versus Moderate Continuous Training in Patients With Heart Failure With Preserved Ejection Fraction: A Systematic Review and Meta-analysis

Cited by 6 publications

References 24 publications

High intensity interval training vs. moderate intensity continuous training on aerobic capacity and functional capacity in patients with heart failure: a systematic review and meta-analysis

High intensity interval training vs. moderate intensity continuous training on aerobic capacity and functional capacity in patients with heart failure: a systematic review and meta-analysis

Relevance of Cardiovascular Exercise in Cancer and Cancer Therapy-Related Cardiac Dysfunction

Exercise, cancer, and the cardiovascular system: clinical effects and mechanistic insights

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