High‐intensity phototherapy for the treatment of severe nonhaemolytic neonatal hyperbilirubinemia

Carvalho, Manoel de; Mochdece, Christieny Chaipp; Sá, Cynthia Amaral Moura; Moreira, Maria Elisabeth Lopes

doi:10.1111/j.1651-2227.2011.02170.x

Cited by 14 publications

(11 citation statements)

References 16 publications

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“…The decrease in TSB in our study was in consistent with Edris AA et al, [20] study who revealed that bilisphere decreased the need for exchange transfusion and shortened the duration of phototherapy. These results are also in agreement with previous studies that show that serum bilirubin levels in neonates may be controlled more effectively with bilisphere (high intensity phototherapy) than with conventional phototherapy [21].…”

Section: Discussionsupporting

confidence: 93%

Effect of Phototherapy on Electrolytes, Liver and Kidney Functions During Treatment of Neonatal Hyperbilirubinemia. A Prospective-Analytical Study

Abohussein

Khalil²,

Fahmy

2022

Annals of Neonatology Journal

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Background: Neonatal jaundice is a frequent problem affecting the newborn with various etiologies. Although phototherapy is considered the standard treatment for neonatal hyperbilirubinemia, it has some complications, as erythematous rashes, diarrhea, hyperthermia and electrolyte disturbance. Objective: To assess the effect of phototherapy on liver enzymes, renal functions, and serum electrolytes in jaundiced neonates before and after phototherapy and to assess changes in biochemical parameters according to mode of treatment including using Bilisphere then phototherapy, IVIG & Bilisphere then phototherapy and phototherapy only. Methods: One hundred neonates with unconjugated hyberbilirubinemia were enrolled. Jaundiced neonates were placed under phototherapy at a distance of 45-50 cm. Laboratory investigations were done before and after phototherapy. Results: Mean (± SD) TSB and DSB significantly declined after phototherapy with p value <0.001. Also, Mean (± SD) levels of AST and ALT showed statistically significant decrease after phototherapy (p<0.001). In addition, Mean (± SD) creatinine and urea levels showed statistically significant decrease after phototherapy (p<0.001).We also found statistically significant decrease in potassium and Calcium levels (p-value < 0.001) after treatment. As regards mode of treatment, we found a statistical significant decrease in TSB, creatinine and calcium among the different modes of treatment (p<0.001). Conclusion: Neonatal hyperbilirubinemia is considered a treatable condition and much of its ill-effects can be eliminated by proper intervention.However, continuous observation of electrolytes as potassium, sodium and calcium is needed as disturbance in their levels is of concern.

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Section: Discussionsupporting

confidence: 93%

Effect of Phototherapy on Electrolytes, Liver and Kidney Functions During Treatment of Neonatal Hyperbilirubinemia. A Prospective-Analytical Study

Abohussein

Khalil²,

Fahmy

2022

Annals of Neonatology Journal

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“…The high correlation also suggests that the percentage of reduction in bilirubin levels during the 6-12-hour interval is closely dependent on the decrease during the 0-6-hour interval. This is also supported by results of the first group in this study as well as those reported by Carvalho et al (14). Moreover, the high correlation suggests a possible relationship between two variables and it is in no way a measure of agreement between them.…”

Section: Relationship Curve Between Percentage Of Reduction and Irrad...supporting

confidence: 91%

“…Similar findings were reported by other authors. Thus, Schindl et al (14) found that the percentage of reduction in bilirubin levels measured at intervals of 2, 4, 6, 12, 18 and 24 hours was 9.4%, 16%, 23%, 40%, 44% and 50%, respectively. If we calculate the percentage of reduction at individual time intervals of 0-2, 2-4 and 4-6 hours, the values come close to each other (9.4%, 7.3% and 8.3%, respectively).…”

Section: Relationship Curve Between Percentage Of Reduction and Irrad...mentioning

confidence: 98%

Pharmacokinetics-Based Optimization of Phototherapy in Neonates Undergoing Treatment for Hyperbilirubinemia

Saikia

Kumar

Velpandian

et al. 2021

Maedica

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“…It is highly likely that this improved the rate of phototherapy response in infants with severe hyperbilirubinemia and played a role in the BET rate decline. 19 , 20 …”

Section: Discussionmentioning

confidence: 99%

Adoption of the American Academy of Pediatrics’ neonatal hyperbilirubinemia guidelines and its effect on blood exchange transfusion rate in a tertiary care center in Amman, Jordan

Al-lawama

Al-Rimawi

Al-Shibi

et al. 2018

JBM

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IntroductionSevere neonatal hyperbilirubinemia can cause mortality and serious morbidities. When phototherapy fails, neonates with severe hyperbilirubinemia should undergo double volume blood exchange transfusion (BET). As this procedure carries a significant risk of mortality and morbidity, adopting guidelines for the treatment of neonatal hyperbilirubinemia is critical to avoid hyperbilirubinemia toxicity and also the complication of an unindicated procedure.MethodsThis study investigated the causes, complications, and trend of BET rate in our unit over a 13-year period. The medical charts and laboratory databases of all infants who underwent BET in Jordan University Hospital between 2003 and 2015 were retrospectively reviewed.ResultsThe rate of exchange cases decreased significantly after adopting the guidelines of American Academy of Pediatrics (P<0.0001). Most neonates were term newborns (69%). Average birth weight was 2,800 g. The most common causes of exchange transfusion were non-hemolytic conditions. Late prematurity alone accounted for 20% of the cases. Thrombocytopenia was the most commonly encountered complication (33%). Chronic neurological complications were seen in 12% of those who were followed for >12 months of age.ConclusionsThis study showed a clear decline in the rate of BET after implementing the guidelines of American Academy of Pediatrics. In addition to improving the strategies for the identification and follow-up of at-risk newborns, we should intensify our efforts to prevent the progression of neonatal hyperbilirubinemia to the exchange level by enhancing parents’ awareness of this potentially harmful neonatal condition.

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High‐intensity phototherapy for the treatment of severe nonhaemolytic neonatal hyperbilirubinemia

Abstract: High-intensity phototherapy significantly reduces TSB in nonhaemolytic severe hyperbilirubinaemia and decreases the need for exchange transfusion.

Cited by 14 publications

References 16 publications

Effect of Phototherapy on Electrolytes, Liver and Kidney Functions During Treatment of Neonatal Hyperbilirubinemia. A Prospective-Analytical Study

Effect of Phototherapy on Electrolytes, Liver and Kidney Functions During Treatment of Neonatal Hyperbilirubinemia. A Prospective-Analytical Study

Pharmacokinetics-Based Optimization of Phototherapy in Neonates Undergoing Treatment for Hyperbilirubinemia

Adoption of the American Academy of Pediatrics’ neonatal hyperbilirubinemia guidelines and its effect on blood exchange transfusion rate in a tertiary care center in Amman, Jordan

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High‐intensity phototherapy for the treatment of severe nonhaemolytic neonatal hyperbilirubinemia

Abstract: High-intensity phototherapy significantly reduces TSB in nonhaemolytic severe hyperbilirubinaemia and decreases the need for exchange transfusion.

Cited by 14 publications

References 16 publications

Effect of Phototherapy on Electrolytes, Liver and Kidney Functions During Treatment of Neonatal Hyperbilirubinemia. A Prospective-Analytical Study

Effect of Phototherapy on Electrolytes, Liver and Kidney Functions During Treatment of Neonatal Hyperbilirubinemia. A Prospective-Analytical Study

Pharmacokinetics-Based Optimization of Phototherapy in Neonates Undergoing Treatment for Hyperbilirubinemia

Adoption of the American Academy of Pediatrics&rsquo; neonatal hyperbilirubinemia guidelines and its effect on blood exchange transfusion rate in a tertiary care center in Amman, Jordan

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Adoption of the American Academy of Pediatrics’ neonatal hyperbilirubinemia guidelines and its effect on blood exchange transfusion rate in a tertiary care center in Amman, Jordan