High-intensity Physical Activity Is Not Associated With Better Cognition in the Elder: Evidence From the China Health and Retirement Longitudinal Study

Wu, Zhiyuan; Zhang, Haiping; Miao, Xinlei; Li, Haibin; Pan, Huiying; Zhou, Di; Liu, Yue; Li, Zhiwei; Wang, Jinqi; Liu, Xiangtong; Zheng, Deqiang; Li, Xia; Wang, Wei; Guo, Xiuhua; Tao, Lixin

doi:10.21203/rs.3.rs-806033/v1

Cited by 4 publications

(4 citation statements)

References 30 publications

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“…First, the disease diagnosis history in the CHARLS was self-reported. However, it has been reported that self-reported cardiovascular diseases were highly consistent with medical records (43,44). Second, the outcome in this study is diagnosis history of any stroke.…”

Section: Discussionmentioning

confidence: 57%

Serum cystatin C and stroke risk: a national cohort and Mendelian randomization study

Qi,

Shang,

Han

et al. 2024

Front. Endocrinol.

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PurposeThe debate over the causal and longitudinal association between cystatin C and stroke in older adults persists. Our aim was to assess the link between cystatin C levels, both measured and genetically predicted, and stroke risk.MethodsThis study employed a retrospective cohort design using samples of the China Health and Retirement Longitudinal Study (CHARLS), which is a nationally representative cohort recruiting individuals aged 45 years or above. A multivariate logistic model and the two-sample Mendelian randomization framework were used to investigate the longitudinal and genetically predicted effect of serum cystatin C on stroke.ResultsThe study population had a mean age of 59.6 (SD ±9.5), with 2,996 (46.1%) women. After adjusting for confounding factors, compared to those in the first quartile of cystatin C, those in the last quartile had the greatest risk of stroke incidence [odds ratio (OR), 1.380; 95% confidence interval (CI), 1.046–1.825]. The Mendelian randomization analysis showed that a genetically predicted cystatin C level was positively associated with total stroke (OR by inverse variance-weighted method, 1.114; 95% CI, 1.041–1.192).ConclusionsThis national cohort study suggests that higher serum cystatin C is associated with an increased risk of total stroke, which is further supported by Mendelian randomization.

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Section: Discussionmentioning

confidence: 57%

Serum cystatin C and stroke risk: a national cohort and Mendelian randomization study

Qi,

Shang,

Han

et al. 2024

Front. Endocrinol.

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“…Thus, they may not engage in various kinds of exercises for body building like their urban counterparts, but may have more daily productive physical activities (Cai et al, 2012). One recent study (Wu et al, 2021) revealed that the cognitive benefits of exercise also depend on its intensity: Whereas mild and moderate physical activity was associated with better cognitive performance, vigorous physical activity was not. So future studies may continuously explore rural/urban differences by separating the exercise and productive physical activities and additionally considering their intensity.…”

Section: Discussionmentioning

confidence: 99%

Leisure Participation and Cognitive Impairment Among Healthy Older Adults in China

et al. 2022

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Leisure participation is beneficial to various health outcomes. This study examined a comprehensive list of leisure activities in relation to incidence of cognitive impairment among healthy older adults (65+) in China. Using data from the 2002 to 2018 Chinese Longitudinal Healthy Longevity Survey, we found that most of the leisure activities were protective of cognitive decline and three leisure activities (watching TV, doing housework, and playing cards/mah-jong) stood out as the most important ones. Additionally, our results revealed subgroup variations in the association between leisure participation and cognitive function: Leisure activities such as reading newspapers/books (not significant for the illiterate), gardening (not significant for the illiterate), and regular exercise (not significant for the rural residents) had different effects across different demographic social groups. Our findings suggest that intervention programs designed to prevent cognitive decline for older adults should consider subgroup and cultural variations in order to yield the best outcomes.

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“…Participants were asked to report their usual weekly PA information based on the IPAQ. Specifically, PA was divided into vigorous PA (VPA), moderate PA (MPA) and light PA (LPA), and described in various dimensions (intensity, duration, frequency and volume; Wu et al, 2021). Considering that the World Health Organization (2020) reports that 1 min of vigorous activity is equal to 2 min of moderate intensity activity (1).…”

Section: Physical Activitymentioning

confidence: 99%

Physical activity trajectories and their determinants in patients with chronic obstructive pulmonary disease: A cohort study

Zhang

Huang

et al. 2023

Journal of Clinical Nursing

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Aims and Objectives:The aim was to identify latent trajectories in physical activity (PA) and their determinants in adults with chronic obstructive pulmonary disease (COPD) based on the socio-ecological model.Background: PA has been linked to poor long-term outcomes in patients with COPD.However, few studies have explored their PA trajectories and their predictors.Design: Cohort study. Methods:We used data from a national cohort and included 215 participants. PA was quantified using a short PA questionnaire, and group-based trajectory modelling was used to explore the PA trajectories. Multinomial logistic regression was conducted to identify the predictors of PA trajectories. Generalised linear mixed models were used to elucidate the associations between predictors and PA during follow-up. A STROBE checklist was used to guide the reporting of this study.Results: Three PA trajectory patterns were identified among 215 COPD participants with an average age of 60.51 ± 8.87: stable inactive group (66.7%), sharp decline group (25.7%) and stable active group (7.5%). The logistic regression showed that age, sex, income, peak expiratory flow, upper limb capacity, depressive symptoms, the frequency of contact with children were PA predictors. Upper limb capacity weakness and depressive symptoms were found to be associated with a sharp decline in PA during follow-up.Conclusions: This study revealed three PA trajectories among patients with COPD. In addition to strengthening the physical functions and mental health of patients, support from the family, community and society also play a crucial role in promoting PA of patients with COPD. Relevance to ClinicalPractice: It is essential to identify distinct PA trajectories in patients with COPD to develop future interventions that promote PA. No Patient or Public Contribution: A national cohort study was used and no patients or the public were involved in the design and implementation of this study.

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High-intensity Physical Activity Is Not Associated With Better Cognition in the Elder: Evidence From the China Health and Retirement Longitudinal Study

Cited by 4 publications

References 30 publications

Serum cystatin C and stroke risk: a national cohort and Mendelian randomization study

Serum cystatin C and stroke risk: a national cohort and Mendelian randomization study

Leisure Participation and Cognitive Impairment Among Healthy Older Adults in China

Physical activity trajectories and their determinants in patients with chronic obstructive pulmonary disease: A cohort study

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