High interleukin-6 plasma levels are associated with low HDL-C levels in community-dwelling older adults: The InChianti study

Zuliani, Giovanni; Volpato, Stefano; Blé, Alessandro; Bandinelli, Stefania; Corsi, A.; Lauretani, Fulvio; Paolisso, Giuseppe; Fellin, Renato; Ferrucci, Luigi

doi:10.1016/j.atherosclerosis.2006.05.024

Cited by 68 publications

(53 citation statements)

References 38 publications

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“…As mentioned in the introduction, inflammation (induced by endotoxin administration) has been reported to be a negative regulator or suppressor of HDL-C levels (Hardardottir et al, 1994;Volpato, Palmieri, Fellin, & Zuliani, 2000;Zuliani et al, 2007). There is also an epidemiological report showing that higher levels of pro-inflammatory IL-6 were associated with lower levels of HDL-C in older adults (Zuliani et al, 2007). Additionally, pro-inflammatory cytokines, such as IFN-g, TNF-a and IL-1b impair reverse cholesterol transport, in which HDL is one of the major constituents (Ohashi, Mu, Wang, Yao, & Chen, 2005).…”

Section: Discussionmentioning

confidence: 99%

Effects of home-based bench step exercise on inflammatory cytokines and lipid profiles in elderly Japanese females: A randomized controlled trial

Nishida

Tanaka

Hara

et al. 2015

Archives of Gerontology and Geriatrics

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Section: Discussionmentioning

confidence: 99%

Effects of home-based bench step exercise on inflammatory cytokines and lipid profiles in elderly Japanese females: A randomized controlled trial

Nishida

Tanaka

Hara

et al. 2015

Archives of Gerontology and Geriatrics

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“…It has also been reported that Se supplementation protects LDL from oxidation and other atherogenic changes [33,34]. HDL possesses anti-atherogenic activity [35] and has been found to protect against the oxidation of LDL by metal ions in vitro [36,37] and by reverse cholesterol transport [38]. In the present study, total cholesterol (P<0.001), triglycerides (P<0.05), and HDL (P<0.05) levels were found to be significantly increased in HCD group in comparison to the control group.…”

Section: Resultsmentioning

confidence: 96%

Studies on Scavenger Receptors under Experimental Hypercholesterolemia: Modulation on Selenium Supplementation

Kaur

Bansal

2010

Biol Trace Elem Res

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Scavenger receptors (SR) are the cell surface proteins that can bind and internalize modified lipoproteins. Because ox-LDL seems to play a key role in foam cell formation during atherogenesis, SR may be critical for pathogenesis of atherosclerosis. The present study was aimed to study the effect of selenium (Se) supplementation on SR, i.e., SRB1 and CD36 under experimental hypercholesterolemia. Male Sprague Dawley rats were divided into three groups and fed on the control diet, high cholesterol diet (HCD), and HCD + Se, respectively, for a period of 4 months. Selenium and reactive oxygen species (ROS) levels were estimated in serum and liver respectively. mRNA expression using RT-PCR and protein expression using ELISA were analyzed for SRB1 and CD36 receptors. Selenium levels decreased whereas ROS levels increased under experimental hypercholesterolemic state. Selenium supplementation (1 ppm), however, diminished the HCD-induced ROS levels. Furthermore, the protein expression of SRB1 was significantly reduced in HCD group in comparison to the control group. On the other hand, HCD-induced increase in CD36 mRNA and protein expression decreased significantly on Se supplementation. In conclusion, CD36 receptors seem to play a pro-atherogenic role under hypercholesterolemic state. Selenium supplementation, in addition, might prove to be a therapeutically valuable approach in near future to limit the adverse effect of hypercholesterolemia.

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“…Several authors have suggested that IL6 with other pro-inflammatory cytokines can influence HDLc levels of by modifying the triglycerides lipase activity [34].…”

Section: Discussionmentioning

confidence: 99%

Correlation between Inflammatory Markers and Lipid Parameters in a Tunisian Coronary Artery Disease Group

Sendesni¹,

Lahidheb²,

Ayoub³

et al. 2016

OALib

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Aims: To evaluate the relationship between inflammatory biomarkers and lipid parameters in a Tunisian coronary artery disease group. Material and Methods: In the study, we have included 122 subjects with acute coronary syndrome (ACS) confirmed by coronary angiography, selected among patients admitted to the cardiology department and 162 subjects free of any cardiovascular disease, recruited from medical and paramedical volunteers. Lipid parameters, high sensitivity CRP (hsCRP) and proinflammatory cytokines (IL6, IL8 and TNFα) were determined for all patients and controls. Results: A highly significant difference (P < 10 −3 ) was noted between the mean of the hsCRP in coronary patients (14.65 ± 9.81 mg/L) compared to controls (1.63 ± 1.75 mg/L). We note also a significant difference between the means of IL6 in the diseased population (11.56 ± 8.23 pg/mL) compared to controls (2.5 ± 0.84 pg/mL) with a value of P < 10

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High interleukin-6 plasma levels are associated with low HDL-C levels in community-dwelling older adults: The InChianti study

Cited by 68 publications

References 38 publications

Effects of home-based bench step exercise on inflammatory cytokines and lipid profiles in elderly Japanese females: A randomized controlled trial

Effects of home-based bench step exercise on inflammatory cytokines and lipid profiles in elderly Japanese females: A randomized controlled trial

Studies on Scavenger Receptors under Experimental Hypercholesterolemia: Modulation on Selenium Supplementation

Correlation between Inflammatory Markers and Lipid Parameters in a Tunisian Coronary Artery Disease Group

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