High intra-abdominal pressure during hyperthermic intraperitoneal chemotherapy (HIPEC) following cytoreductive surgery (CRS) for peritoneal surface malignancies

Wong, Louis Choon Kit; Wong, Jolene Si Min; Seo, Chin Jin; Soo, Khee Chee; Ong, Chin-Ann Johnny; Chia, Claramae Shulyn

doi:10.1080/02656736.2022.2121861

Cited by 4 publications

(2 citation statements)

References 28 publications

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“…Conversely, the closed technique limits the contamination of the environment and achieves the hyperthermic state more e ciently. The closed technique with its high intra-abdominal pressure has been reported to be safe in humans and to increase the tissue concentration of the drug in the peritoneum [11][12][13]. Despite its reported safety, it is essential to emphasize the risk of abdominal compartment syndrome during closed HIPEC and the importance of its proper management.…”

Section: Discussionmentioning

confidence: 99%

Abdominal compartment syndrome during intraoperative hyperthermic intraperitoneal chemotherapy following debulking surgery for colorectal cancer: a case report

Chiu,

Lu,

Lin

et al. 2023

Preprint

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Background Colorectal cancer frequently leads to peritoneal metastasis and necessitates treatments, such as hyperthermic intraperitoneal chemotherapy (HIPEC). However, HIPEC may result in perioperative complications, some often overlooked, such as abdominal compartment syndrome. Case presentation A 52-year-old female with colorectal cancer and peritoneal metastasis underwent debulking surgery followed by HIPEC. Extensive tumour burden and a 9-hour surgery resulted in a blood loss of 3200 mL; 10 units of packed red blood cells were transfused. During HIPEC, a sudden increase in airway pressure and severe hypotension were noted. The abdomen was tensed, thus suggesting abdominal compartment syndrome, and prompting termination of HIPEC and drainage of the chemotherapeutic solution. Despite intravenous fluids and vasopressors, she experienced circulatory and respiratory collapse. Laparotomy sutures were promptly removed, which effectively alleviated the intra-abdominal hypertension and immediately restored the vital signs. An inadequately repaired diaphragm defect was identified and repaired. A chest tube was inserted for pneumothorax. Conclusions Abdominal compartment syndrome is a critical complication of HIPEC. It can mimic HIPEC’s physiological effects and result in adverse outcomes.

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Section: Discussionmentioning

confidence: 99%

Abdominal compartment syndrome during intraoperative hyperthermic intraperitoneal chemotherapy following debulking surgery for colorectal cancer: a case report

Chiu,

Lu,

Lin

et al. 2023

Preprint

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“…Hyperthermic intraperitoneal chemotherapy (HIPEC) following cytoreductive therapy has become a common treatment for peritoneal metastases from mesothelioma, colorectal, gastric, appendiceal, ovarian, and primary peritoneal cancer 1 . Advantages include higher concentrations of heated chemotherapeutic agents with improved cytotoxicity and limited systemic side effects 2 .…”

Section: Introductionmentioning

confidence: 99%

Development of a predictive model for risk stratification of acute kidney injury in patients undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy

Krause,

Mehdipour,

Veerapong

et al. 2024

Sci Rep

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Acute kidney injury (AKI) following hyperthermic intraperitoneal chemotherapy (HIPEC) is common. Identifying patients at risk could have implications for surgical and anesthetic management. We aimed to develop a predictive model that could predict AKI based on patients’ preoperative characteristics and intraperitoneal chemotherapy regimen. We retrospectively gathered data of adult patients undergoing HIPEC at our health system between November 2013 and April 2022. Next, we developed a model predicting postoperative AKI using multivariable logistic regression and calculated the performance of the model (area under the receiver operating characteristics curve [AUC]) via tenfold cross-validation. A total of 412 patients were included, of which 36 (8.7%) developed postoperative AKI. Based on our multivariable logistic regression model, multiple preoperative and intraoperative characteristics were associated with AKI. We included the total intraoperative cisplatin dose, body mass index, male sex, and preoperative hemoglobin level in the final model. The mean area under the receiver operating characteristics curve value was 0.82 (95% confidence interval 0.71–0.93). Our risk model predicted AKI with high accuracy in patients undergoing HIPEC in our institution. The external validity of our model should now be tested in independent and prospective patient cohorts.

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Abdominal compartment syndrome during intraoperative hyperthermic intraperitoneal chemotherapy following debulking surgery for colorectal cancer: A case report

Chiu,

Lu,

Lin

et al. 2024

International Journal of Surgery Case Reports

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High intra-abdominal pressure during hyperthermic intraperitoneal chemotherapy (HIPEC) following cytoreductive surgery (CRS) for peritoneal surface malignancies

Cited by 4 publications

References 28 publications

Abdominal compartment syndrome during intraoperative hyperthermic intraperitoneal chemotherapy following debulking surgery for colorectal cancer: a case report

Abdominal compartment syndrome during intraoperative hyperthermic intraperitoneal chemotherapy following debulking surgery for colorectal cancer: a case report

Development of a predictive model for risk stratification of acute kidney injury in patients undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy

Abdominal compartment syndrome during intraoperative hyperthermic intraperitoneal chemotherapy following debulking surgery for colorectal cancer: A case report

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