High intratumoral expression of vimentin predicts histological transformation in patients with follicular lymphoma

Madsen, Charlotte Bernhard; Lauridsen, Kristina Lystlund; Plesner, Trine Lindhardt; Monrad, Ida; Honoré, Bent; Hamilton-Dutoit, Stephen; d’Amore, Francesco; Ludvigsen, Maja

doi:10.1038/s41408-019-0197-5

Cited by 15 publications

(18 citation statements)

References 16 publications

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“…Clinical data from all patients were included, collected from the Danish Lymphoma Registry (LYFO) [21] and patient records. These data together with immunohistochemical data on vimentin and PAX5 tissue expression in this cohort have previously been published [22].…”

Section: Patientssupporting

confidence: 63%

“…This is the second study, we have reported, in which markers initially identified in our 2D-PAGE/MSbased proteomics analysis [11], have shown to be of predictive potential when assessed by immunohistochemistry on FFPE tissue in this patient cohort. The first of these markers was vimentin which we also found to be predictive of HT risk, based on intratumoral expression levels [22]. It is evident from our data that the expression levels of these biomarkers vary within each group (nt-FL, s-FL).…”

Section: Plos Onesupporting

confidence: 52%

“…Stained slides of whole biopsy sections were scanned at a magnification of x20 using the Hamamatsu Nanozoomer 2.0HT scanner (Hamamatsu, Shizuoka, Japan). Staining quantification was performed using Visiopharm Integrator system 2018.09 (Visiopharm A/S, Hoersholm, Denmark) [22]. All digitalized images of whole biopsy sections were manually reviewed for large areas of distinct non-lymphoid tissue, fatty tissue, tissue folds, artefacts, etc.…”

Section: Digital Image Analysismentioning

confidence: 99%

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Glycolytic biomarkers predict transformation in patients with follicular lymphoma

et al. 2020

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Follicular lymphoma (FL) is an indolent neoplasia comprising approximately 20% of lymphomas. FL is generally considered incurable, with a median survival exceeding 10 years. A subset of FL patients experiences histological transformation (HT) to a more aggressive lymphoma, resulting in markedly poorer clinical outcome, with a reduced median survival after transformation of 1-2 years. Early, reliable prediction of HT would be valuable in the clinical setting, allowing pre-emptive therapeutic intervention. We previously used proteomics to identify the glycolytic enzymes fructose-bisphosphate aldolase A (aldolase A) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as candidate predictors of FL transformation. Now, we use immunohistochemistry to evaluate expression of these enzymes in paired primary FLs from patients with (n = 41) or without subsequent HT (n = 49), to test their value as predictive biomarkers. At initial FL diagnosis, patients with subsequent HT had significantly higher expression of aldolase A and GAPDH (p<0.001 and p<0.01) compared with patients without HT. Furthermore, high expression of aldolase A and GAPDH was associated with significantly shorter transformation free survival (p = 0.018, p = 0.001). These data suggest that high expression of aldolase A and GAPDH, may indicate increased metabolic turnover, and that these enzymes may be useful biomarkers in primary FL for predicting the risk of subsequent lymphoma transformation.

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Section: Patientssupporting

confidence: 63%

Section: Plos Onesupporting

confidence: 52%

Section: Digital Image Analysismentioning

confidence: 99%

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Glycolytic biomarkers predict transformation in patients with follicular lymphoma

et al. 2020

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“…Biomarkers that could reliably predict HT, and thus identify patients at increased risk of transformation, would be highly valuable in the clinical setting. To date, both clinical features and biological markers have been investigated as possible risk factors for HT, 7 , 8 , 11 , 12 but no definitive biomarkers of transformation have yet been identified. Known factors associated with poor prognosis in FL include advanced Ann Arbor stage, elevated lactate dehydrogenase (LDH), B-symptoms as well as a high Follicular Lymphoma International Prognostic Index (FLIPI) score.…”

Section: Introductionmentioning

confidence: 99%

“…We reported differences in expression of various proteins, including vimentin, GAPDH and aldolase A, in diagnostic FL samples from patients with subsequent transformation compared with those without. 11–13 …”

Section: Introductionmentioning

confidence: 99%

PD-1 Expression in Pre-Treatment Follicular Lymphoma Predicts the Risk of Subsequent High-Grade Transformation

Enemark¹,

Monrad²,

Madsen³

et al. 2021

OTT

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Multi-omic profiling of follicular lymphoma reveals changes in tissue architecture and enhanced stromal remodeling in high-risk patients

Radtke,

Postovalova,

Varlamova

et al. 2024

Cancer Cell

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High intratumoral expression of vimentin predicts histological transformation in patients with follicular lymphoma

Cited by 15 publications

References 16 publications

Glycolytic biomarkers predict transformation in patients with follicular lymphoma

Glycolytic biomarkers predict transformation in patients with follicular lymphoma

PD-1 Expression in Pre-Treatment Follicular Lymphoma Predicts the Risk of Subsequent High-Grade Transformation

Multi-omic profiling of follicular lymphoma reveals changes in tissue architecture and enhanced stromal remodeling in high-risk patients

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