High-irradiance accelerated collagen crosslinking for the treatment of keratoconus: Six-month results

Abstract

No author has a financial or proprietary interest in any material or method mentioned.

Factors affecting visual acuity after accelerated crosslinking in patients with progressive keratoconus

“…Elbaz et al retrospectively studied the efficacy of accelerated CXL in 16 keratoconus-affected eyes and reported the effectiveness of this procedure for the stabilization of topographic parameters, including Ksteep, Kflat, average K, corneal astigmatism, and maximal curvature reading at the corneal apex, after 12 months of follow-up (14) . Mita et al also evaluated the effectiveness of accelerated CXL in 39 eyes and reported significantly improved UCVA and Kmax values at 6 months after treatment (15) . The maximum keratometry value (Kmax or AKf ) has been considered a key topographic indicator of CXL success, and has been reported as stable or decreased after CXL in many studies (3,(15)(16)(17) .…”

“…Mita et al also evaluated the effectiveness of accelerated CXL in 39 eyes and reported significantly improved UCVA and Kmax values at 6 months after treatment (15) . The maximum keratometry value (Kmax or AKf ) has been considered a key topographic indicator of CXL success, and has been reported as stable or decreased after CXL in many studies (3,(15)(16)(17) . Similarly, we also observed significantly decreased AKf values after treatment.…”

Accelerated Corneal Crosslinking Results with Respect to Age Groups

“…23 Similarly, variable results (0.06-0.8 D) were obtained in adult groups following accelerated corneal CXL. 15,25 Another finding of our study was that the number of patients whose progression did not halt was higher in the pediatric group (5/41) compared to the adult group (2/47). This is probably due to the fact that keratoconus is more aggressive at pediatric ages.…”

“…Previous studies did not identify any endothelial toxicity in accelerated corneal CXL. 8,15 Another limitation of the study is that we measured the aberration using Pentacam. According to the literature, there are conflicting data on the repeatability of Pentacam in the measurement of aberrations.…”

“…12 To prevent thinning, current discussions focus on the use of an iso-osmolar riboflavin solution without dextran (with hydrocypropylmethylcellulose) and hypo-osmolar riboflavin solution for thick corneas. 14,15 Therefore, the use of hypo-osmolar riboflavin solution has become a standard in our clinic.…”