High level of mature tumor-infiltrating dendritic cells predicts progression to muscle invasion in bladder cancer

Ayari, Cherifa; LaRue, Hélène; Hovington, Hélène; Caron, André; Bergeron, Alain; Têtu, Bernard; Fradet, Vincent

doi:10.1016/j.humpath.2013.01.014

Cited by 33 publications

(29 citation statements)

References 30 publications

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“…This possibility is supported by our observation that !T1b cases included numerous high-CD3 tumours. More recently, Ayari et al [27] noted that the presence of mature dendritic CD83 cells is associated with tumour progression. It is clear that the role of the host immune system in tumour progression needs to be further investigated.…”

Section: Discussionmentioning

confidence: 99%

A Molecular Pathologic Framework for Risk Stratification of Stage T1 Urothelial Carcinoma

et al. 2015

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Section: Discussionmentioning

confidence: 99%

A Molecular Pathologic Framework for Risk Stratification of Stage T1 Urothelial Carcinoma

et al. 2015

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“…In fact, DC levels in the urine could be used to monitor the efficacy of BCG and other bladder immunotherapies. Very recently, the findings of Ayari et al [68] suggest that the presence of mature tumor-infiltrated DCs and potentially tumor-associated macrophages may be helpful in stratifying the patients at risk at the time of initial diagnosis of non-muscle-invasive bladder cancer and thus could assist in developing treatment strategies in the follow-up of the bladder cancer patient.…”

Section: Dendritic Cellsmentioning

confidence: 99%

Immunological basis in the pathogenesis and treatment of bladder cancer

Thompson

Siref

Feloney

et al. 2014

Expert Review of Clinical Immunology

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The pathogenesis and transition of normal urothelium into bladder carcinoma are multifactorial processes. Chronic inflammation causes initiation and progression of the underlying pathophysiology of invasive and metastatic cancer. A dichotomy is observed in the role of immune cells in bladder cancer. While the immune response defends the host by suppressing neoplastic growth, several immune cells, including neutrophils, macrophages, and T-lymphocytes, promote tumor development and progression. The levels of human neutrophil peptide-1, -2, and -3, produced by neutrophils, increase in bladder cancer and might promote tumor angiogenesis and growth. The effect of macrophages is primarily mediated by pro-inflammatory cytokines, IL-6 and TNF-α. Additionally, the underlying immunological mechanisms of two treatments, BCG and cytokine gene-modified tumor vaccines, and future directions are critically discussed.

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“…The presence of TAMs correlates with poor prognosis in several different cancer types [8][9][10][11][12][13]. For example intratumoral TAM density is significantly increased in higher stage and grade in ovarian cancer [14].…”

mentioning

confidence: 99%

Tumor-associated macrophages: Co-conspirators and orchestrators of immune suppression in endometrial adenocarcinoma

Zsiros¹,

Odunsi²

2014

Gynecologic Oncology

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High level of mature tumor-infiltrating dendritic cells predicts progression to muscle invasion in bladder cancer

Cited by 33 publications

References 30 publications

A Molecular Pathologic Framework for Risk Stratification of Stage T1 Urothelial Carcinoma

A Molecular Pathologic Framework for Risk Stratification of Stage T1 Urothelial Carcinoma

Immunological basis in the pathogenesis and treatment of bladder cancer

Tumor-associated macrophages: Co-conspirators and orchestrators of immune suppression in endometrial adenocarcinoma

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