High level of tumor marker CA19-9 returned to normal after cholecystectomy in calculous cholecystitis patients

Chen, Wanjin; Wang, Shouwen; Zhao, Hua-Lu; Wang, Guobin; Rong, Qin; Huang, Fan; Geng, Wei; Liu, Zimei; Wang, Wei; Wu, Ruolin; Hou, Liujin; Ye, Zhenghui; Zhang, Xinghua; Geng, Xiaoping; Yu, Xiaojun

doi:10.1080/00365521.2022.2163184

Cited by 2 publications

(1 citation statement)

References 24 publications

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“…Following examination, it was found that there were no tumor lesions, and the level of CA199 returned to normal after ERCP. It was recently reported by Chen et al ( 37 ) that CA199 is associated with calculous cholecystitis. The level of CA199 was found to be elevated in certain patients with calculous cholecystitis but without tumor disease, whereas the level of CA199 in these patients returned to normal following cholecystectomy.…”

Section: Discussionmentioning

confidence: 91%

ERCP endoscopic minimally invasive treatment of acute suppurative obstructive cholangitis: A study of 47 patients

Lu,

Fan

2024

Exp Ther Med

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The primary objective of the present study was to investigate the efficacy and safety of endoscopic therapy for acute obstructive suppurative cholangitis (AOSC) in patients with different underlying conditions. The present study comprised 47 patients diagnosed with AOSC, with a mean age of 70±14 years. Minimally invasive endoscopic treatments, including endoscopic duodenal papillary sphincterotomy, endoscopic duodenal nasobiliary drainage and/or placement of an endobiliary duct stent drainage tube, were performed. Variations in the levels of the white blood cell count, liver function, procalcitonin (PCT) and carbohydrate antigen-199 (CA199) were examined, compared and evaluated both prior to and following endoscopic retrograde cholangiopancreatography (ERCP). Among the 47 patients, 45 had a high fever, although their body temperature returned to normal after 7 days of ERCP treatment. The infection was difficult to control completely in two cases, including one case of biliary anastomosis secondary tumor with stenosis and AOSC and another case of an elderly patient with multiple choledocholithiasis complicated with sepsis. Within 7 days following treatment, the abdominal pain was resolved in 27 patients and jaundice subsided in 29 patients. On the 7th day after endoscopic treatment, the blood leukocyte, liver function, PCT and CA-199 parameters of all patients were significantly improved compared with those at admission. A total of 35 bile cultures yielded positive results, with Escherichia coli accounting for 11 cases (31.4%), Klebsiella pneumoniae accounting for 7 cases (20%), Pseudomonas aeruginosa accounting for 5 cases (14.3%), Enterococcus faecus accounting for 4 cases (11.4%) and other strains making up the remaining 17 cases. No serious complications were encountered with these patients, such as perforation, bleeding, severe pancreatitis or mortality, following ERCP. In conclusion, ERCP has been shown to be a safe and effective minimally invasive treatment method for elderly patients with AOSC, yielding a high rate of success.

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Section: Discussionmentioning

confidence: 91%

ERCP endoscopic minimally invasive treatment of acute suppurative obstructive cholangitis: A study of 47 patients

Lu,

Fan

2024

Exp Ther Med

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Formation and rupture of liver hematomas caused by intrahepatic gallbladder perforation: A case report and review of literature

Huang,

Wang,

Leng

et al. 2024

World J Gastrointest Surg

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BACKGROUND Gallbladder perforation is a serious complication of acute cholecystitis. Such perforation is a rare but life-threatening situation that can lead to the formation and rupture of liver hematomas. Here, we report a case of a ruptured intrahepatic hematoma caused by intrahepatic gallbladder perforation, and we present a literature review. CASE SUMMARY A 70-year-old male was admitted to the hospital with a complaint of right upper quadrant abdominal pain, flustering and dizziness. The preoperative diagnosis was a ruptured malignant liver tumor, and the patient’s medical images and increased level of carbohydrate antigen-199 suggested that the gallbladder had been invaded. However, the tumor was proven to be a liver hematoma secondary to gallbladder perforation after surgery. The patient was discharged uneventfully on the fifteenth postoperative day. CONCLUSION Intrahepatic gallbladder perforation is difficult to diagnose preoperatively. Radiological examinations play a crucial role in the diagnosis but only for partial cases. Early diagnosis and appropriate surgery are key to managing this rare condition.

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High level of tumor marker CA19-9 returned to normal after cholecystectomy in calculous cholecystitis patients

Cited by 2 publications

References 24 publications

ERCP endoscopic minimally invasive treatment of acute suppurative obstructive cholangitis: A study of 47 patients

ERCP endoscopic minimally invasive treatment of acute suppurative obstructive cholangitis: A study of 47 patients

Formation and rupture of liver hematomas caused by intrahepatic gallbladder perforation: A case report and review of literature

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