High-level pyrantel resistance in the hookworm Ancylostoma caninum

Kopp, Steven; Kotze, Andrew C.; McCarthy, James S.; Coleman, Glen

doi:10.1016/j.vetpar.2006.08.036

Cited by 102 publications

(69 citation statements)

References 15 publications

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“…These finding are similar to those reported by Fisher (2003) However, some studies have reported Ancylostoma to be more prevalent than Toxocara in dog excrement samples, including Kopp et al (2007), who analyzed animal between three and six months of age; Lorenzini et al (2007) who studied animals one year of age; and Prates et al (2009), Ramirez-Barrios et al (2004, and Swai et al (2010), who analyzed dogs in different age ranges. Dogs of all ages can be infected by A. caninum because they do not develop effective immunity against this helminth (BLAZIUS et al, 2005;BOAG et al, 2003).…”

Section: Resultssupporting

confidence: 85%

“…Gastroenteritis may occur in dogs of all ages, but is most common in neonates and animals less than six months of age, primarily due to their immature immune systems and transmammary and transplacental transmission (BOWMAN et al, 2010;RAMIREZ-BARRIOS et al, 2004 HOPKINS et al, 1998;KOPP et al, 2007).…”

Section: Among Infections Common In Dogsmentioning

confidence: 99%

“…However, Kopp et al (2007) tested the efficacy of a 14.4 mg/kg dose of pyrantel pamoate in dogs artificially infected with A. caninum, reporting increased egg production and only 25.7% reduction of adult parasites in the intestines after six days of treatment compared with the untreated control group, suggesting parasite resistance to the drug. Toxocara in this study appeared slightly more resistant to pyrantel pamoate, with an FECRT 10 days after treatment of 93.5%.…”

Section: Fecrt (%) G1 Fecrt (%) G2mentioning

confidence: 99%

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Efficacy of pyrantel pamoate and ivermectin for the treatment of canine nematodes

et al. 2015

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This study evaluated the efficacy of pyrantel pamoate and ivermectin on gastrointestinal nematodes in dogs. Fecal egg counts per gram (EPG) were measured by the fecal egg count reduction test (FECRT) in order to evaluate the anthelmintic efficiency and fecal float exams were also performed to assess the concordance between coproparasitological techniques. A total of 45 naturally infected dogs in the city of Bandeirantes, Paraná State, were selected and divided into three groups: Group 1, 15 animals that received pyrantel pamoate (145 mg) in a single dose; Group 2, 15 animals that received ivermectin (3 mg); and Group 3, 15 animals that comprised an untreated control group. Fecal testing was performed two and 10 days after treatment. Toxocara was the most prevalent genus, followed by Ancylostoma and Trichuris. Ancylostoma had low resistance to ivermectin and pyrantel pamoate treatment, while Toxocara were resistant to both treatments. Statistical correlation testing to compare coproparasitogical techniques revealed moderate concordance, substantial and almost perfect concordance for detection of Ancylostoma, Trichuris, and Toxocara, respectively. The results of this study suggest that the gender Ancylostoma had low resistance and Toxocara is resistant to both drugs and because of their high prevalence in young animals means that others anthelmintic drugs may be recommended to combat infections. Additionally, the Gordon and Whitlock modified and Willis-Mollay techniques are effective for detection particularly of Toxocara in dogs. Key words: Ancylostomiasis, dogs, parasitic resistance, toxocariasis ResumoObjetivou-se neste estudo avaliar a eficácia do pamoato pirantel e da ivermectina sobre nematódeos gastrointestinais de cães. Para tanto foram realizados a contagem de ovos nas fezes (OPG) para avaliação da eficiência anti-helmíntica através do Teste de Redução da Contagem de Ovos nas Fezes (RCOF) e exame de flutuação Willis-Mollay para verificação de concordância entre as técnicas coproparasitológicas. Selecionou-se 45 cães na cidade de Bandeirantes, Paraná, naturalmente infectados, os quais foram divididos em três grupos experimentais: Grupo 1, 15 animais que receberam pamoato de pirantel 145 mg; Grupo 2, 15 animais que receberam ivermectina 3 mg e Grupo 3, 15 animais do grupo controle, não tratados. Coletas de fezes foram realizadas dois e dez dias depois para realização dos exames coproparasitológicos. Observou-se que o gênero de maior prevalência foi Toxocara, seguido de Ancylostoma e Trichuris. Ancylostoma apresentou baixa resistência ao tratamento

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Section: Resultssupporting

confidence: 85%

Section: Among Infections Common In Dogsmentioning

confidence: 99%

Section: Fecrt (%) G1 Fecrt (%) G2mentioning

confidence: 99%

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Efficacy of pyrantel pamoate and ivermectin for the treatment of canine nematodes

et al. 2015

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“…Continued use is, however, dependent upon the target nematodes remaining susceptible to the drug. Resistance to pyrantel has now been described in nematodes of horses (3,4), pigs (25), and canines (6,12); and a single report of pyrantel failure against a human hookworm, Ancylostoma duodenale, in Australia exists (20).…”

mentioning

confidence: 99%

Phenotypic Characterization of Two Ancylostoma caninum Isolates with Different Susceptibilities to the Anthelmintic Pyrantel

Kopp

Coleman

McCarthy

et al. 2008

Antimicrob Agents Chemother

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The anthelmintic pyrantel plays an important role in the control of gastrointestinal helminths of humans and domestic animals. Despite the demonstration of pyrantel resistance in several helminth species over the last 20 years, the resistance mechanism remains unclear. It has been hypothesized that resistance may arise as a consequence of changes to the relative proportions of subpopulations of nicotinic acetylcholine receptors (nAchRs). To test this hypothesis, we examined the responses of two isolates of the canine hookworm Ancylostoma caninum with low-level resistance (isolate NT) and high-level resistance (isolate PR) to pyrantel to nicotinic agonist drugs reported to be selective for three nAchR subtypes. We used larval motility and conformation assays and force transduction experiments with adult worms. Pyrantel and levamisole were less potent against larvae of isolate PR than larvae of isolate NT (up to an 18-fold increase in the 50% inhibitory concentration); on the other hand, bephenium was more potent against larvae of isolate PR than larvae of isolate NT (twofold) and nicotine had the same potency against larvae of both isolates. In adults, pyrantel, levamisole, and nicotine were less potent against isolate PR than isolate NT (two-to threefold), but the potency of bephenium against the two isolates was equivalent. Our data indicate a complex pattern of nAchRs in this species and suggest that the two isolates differ in their relative sensitivities to agonists targeting different nAchRs.

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“…Anthelmintic resistance has been documented in parasites of different animal species, including cattle (e.g., Eagleson and Bowie, 1986;Loveridge et al, 2003;Mejia et al, 2003;Rendell, 2010), sheep and goats (e.g., Barton, 1983;Overend et al, 1994;Eddi et al, 1996;Coles, 2005;Domke et al, 2012), horses (e.g., Kaplan, 2002;Traversa et al, 2009;Reinemeyer, 2012) and dogs (e.g., Jackson et al, 1987;Kopp et al, 2007). AR is a major issue with trichostrongyloid nematodes of small ruminants and reports of H. contortus resistant to multiple classes of anthelmintics are becoming more common; therefore, most research has been focused on this group of GINs (e.g., Sangster and Gill, 1999;Kaplan, 2004;Howell et al, 2008).…”

Section: Control Of Parasitic Nematodesmentioning

confidence: 99%

The role of drug efflux systems in anthelmintic resistance in parasitic nematodes

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High-level pyrantel resistance in the hookworm Ancylostoma caninum

Cited by 102 publications

References 15 publications

Efficacy of pyrantel pamoate and ivermectin for the treatment of canine nematodes

Efficacy of pyrantel pamoate and ivermectin for the treatment of canine nematodes

Phenotypic Characterization of Two Ancylostoma caninum Isolates with Different Susceptibilities to the Anthelmintic Pyrantel

The role of drug efflux systems in anthelmintic resistance in parasitic nematodes

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