This paper presents the design, implementation, and experimental results of 32-bit asynchronous microprocessor developed in a synchronous reconfigurable device (FPGA), taking advantage of a hard macro. It has support for floating point operations, such as addition, subtraction, and multiplication, and is based on the IEEE 754-2008 standard with 32-bit simple precision. This work describes the different blocks of the microprocessors as delay modules, needed to implement a Self-Timed (ST) protocol in a synchronous system, and the operational analysis of the asynchronous central unit, according to the developed occupations and speeds. The ST control is based on a micropipeline used as a centralized generator of activation signals that permit the performance of the operations in the microprocessor without the need of a global clock. This work compares the asynchronous microprocessor with a synchronous version. The parameters evaluated are power consumption, area, and speed. Both circuits were designed and implemented in an FPGA Virtex 5. The performance obtained was 4 MIPS for the asynchronous microprocessor against 1.6 MIPS for the synchronous.